Abstract: Apparatus, kit and method embodiments are disclosed herein that provide for the production of a modified autologous platelet mixture at a patient bedside for contemporaneous reinjection to the patient using a platelet lysis apparatus. Representative platelet lysis apparatus may include a housing supporting a sample tube and a thermal mass element connected to or near the sample tube. The thermal mass element may be separable from the housing, and/or the sample tube may be separable from the thermal mass element.
Type:
Grant
Filed:
December 23, 2020
Date of Patent:
February 20, 2024
Assignee:
Regenexx, LLC
Inventors:
Christopher J. Centeno, Neven Steinmetz, Ian Stemper, Dustin Berger
Abstract: Apparatus, kit and method embodiments are disclosed herein that provide for the production of a modified autologous platelet mixture at a patient bedside for contemporaneous reinjection to the patient using a platelet lysis apparatus. Representative platelet lysis apparatus include a sample tube and a compressed gas source connected to or near the sample tube. The compressed gas source provides for the release of expanding gas into direct or indirect contact with an exterior surface of the sample tube to freeze a platelet containing mixture within the sample tube. An optional housing supports the sample tube and compressed gas source in an operative relationship with each other.
Type:
Grant
Filed:
December 22, 2017
Date of Patent:
February 2, 2021
Assignee:
REGENEXX, LLC.
Inventors:
Christopher J. Centeno, Neven Steinmetz, Ian Stemper, Dustin Berger
Abstract: Autologous compositions and methods are provided for cartilage repair in patients in need thereof. Some aspects include combinations of platelet-based materials with chondrogenesis inducing agents in the presence or absence of cell-based therapies.
Abstract: The embodiments disclosed herein generally relate to systems, devices and methods for the fractionation, isolation, extraction and processing of the adipose supernatant layer of a bone marrow aspirate. In particular, the various embodiments relate to systems devices and methods of obtaining, utilizing and processing the adipose supernatant layer of a bone marrow aspirate as a source of mesenchymal stem cells.
Type:
Grant
Filed:
April 20, 2018
Date of Patent:
January 21, 2020
Assignee:
Regenexx LLC
Inventors:
Christopher Centeno, Ryan Dregalla, Nicolette Lyons, Patrick Reischling
Abstract: Embodiments include systems, methods and devices for the percutaneous delivery of therapeutic agents to tendons, ligaments and muscle. Certain embodiments include a device comprising a needle-catheter based delivery system with adjustable characteristics to allow a clinician to control the angle and depth of needle and/or catheter deployment to a desired location. System embodiments may include a controller unit where a clinician can adjust the axial position depth and location of needles and/or catheters.
Type:
Grant
Filed:
January 20, 2015
Date of Patent:
July 16, 2019
Assignee:
Regenexx, LLC
Inventors:
Christopher Centeno, Patrick Reischling, Timothy Snyder
Abstract: Apparatus, systems and methods for processing a blood sample. One embodiment comprises an isolation container having at least one sidewall defining an interior volume. The interior volume includes a medial reservoir in fluid communication with proximal and distal reservoirs. The diameter of the medial reservoir is less than the diameter of the proximal and distal reservoirs. Therefore, the isolation container has an interior volume which is roughly hour-glass shaped with the medial reservoir being a substantially narrowed portion or channel between two wider portions. The isolation container is configured such that the buffy coat layer of fractionated blood will be located within and may be accessed from the reduced cross sectional medial reservoir after a centrifuge or other processing step.
Type:
Grant
Filed:
February 18, 2014
Date of Patent:
October 2, 2018
Assignee:
Regenexx, LLC
Inventors:
Christopher J. Centeno, Brian Leach, Ryan Dregalla, Patrick Reischling
Abstract: The embodiments disclosed herein generally relate to systems, devices and methods for the fractionation, isolation, extraction and processing of the adipose supernatant layer of a bone marrow aspirate. In particular, the various embodiments relate to systems devices and methods of obtaining, utilizing and processing the adipose supernatant layer of a bone marrow aspirate as a source of mesenchymal stem cells.
Type:
Grant
Filed:
August 6, 2014
Date of Patent:
May 22, 2018
Assignee:
Regenexx, LLC
Inventors:
Christopher Centeno, Ryan Dregalla, Nicolette Lyons, Patrick Reischling