Abstract: The invention relates to methods for producing a polymeric scaffold for use in tissue engineering applications or soft tissue surgery, as well as to the produced scaffolds and an associated kit. The method features a first fast drying step of applying a mechanical compression on a polymeric gel layer and a second slow drying step of the gel up to reach a polymer mass fraction of at least 60% w/w in the final scaffold. The method allows the production of scaffolds with high regeneration and healing properties of a grafted tissue via host cell invasion and colonization, and a good suturability. These goals are achieved through the formation within the scaffold of a non-uniform architecture creating softer and stiffer areas, which is maintained even upon re-swelling of the scaffold upon hydration of the final dried product.
Type:
Grant
Filed:
March 29, 2017
Date of Patent:
March 8, 2022
Assignee:
Regenosca SA
Inventors:
Peter Frey, Jeffrey A. Hubbell, Hans M. Larsson, Elif Vardar, Eva-Maria Balet, Ganesh Vythilingam, Kalitha Pinnagoda