Patents Assigned to REGENRON PHARMACEUTICALS, INC.
  • Modified Chimeric Polypeptides with Improved Pharmacokinetic Properties
    Publication number: 20110028698
    Abstract: Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal.
    Type: Application
    Filed: September 17, 2010
    Publication date: February 3, 2011
    Applicant: REGENRON PHARMACEUTICALS, INC.
    Inventors: Nicholas J. Papadopoulos, Samuel Davis, George D. Yancopoulos