Patents Assigned to Regent of the University of Minnesota
  • Publication number: 20200373491
    Abstract: Self-organizing patterns with micrometer-scale feature sizes are promising for the large area fabrication of photonic devices and scattering layers in optoelectronics. Pattern formation would ideally occur in the active semiconductor to avoid the need for further processing steps. The present disclosure includes approaches to form period patterns in single layers of organic semiconductors by an annealing process. When heated, a crystallization front propagates across the film, producing a sinusoidal surface structure with wavelengths comparable to that of near-infrared light. These surface features form initially in the amorphous region within a micron of the crystal growth front, likely due to competition between crystal growth and surface mass transport. The pattern wavelength can be tuned by varying film thickness and annealing temperature, millimeter scale domain sizes are obtained. Aspects of the disclosure can be exploited for self-assembly of microstructured organic optoelectronic devices, for example.
    Type: Application
    Filed: May 22, 2020
    Publication date: November 26, 2020
    Applicant: Regents of the University of Minnesota
    Inventors: Russell J. Holmes, John David Myers-Bangsund, Thomas Robert Fielitz
  • Publication number: 20200368096
    Abstract: A comprehensive system for treatment of wrist joint proprioception. The system includes a manipulandum unit and a controller. The unit includes a base, a handle, a linkage assembly, and motors. The base supports a subject's forearm, and the handle is gripped by the palm. The linkage assembly connects the handle to the base, and establishes three DOFs. The motors are operatively connected to the linkage assembly. The controller is programmed to actuate, and receive feedback information from, each of the plurality of motors. Further, the controller is programmed to perform wrist proprioception assessment operations by actuating the plurality of motors to effectuate movement of the handle relative to the base in a prescribed manner indicative of position motion sense acuity as an objective measure of wrist proprioception functioning. The controller is optionally further programmed to perform rehabilitation training via controlled operation of the unit and a virtually reality environment.
    Type: Application
    Filed: August 14, 2020
    Publication date: November 26, 2020
    Applicants: Regents of the University of Minnesota, Nanyang Technological University, Fondazione Istituto Italiano di Tecnologia (Italian Institute of Technology), Università degli Studi di Genova (University of Genoa)
    Inventors: Lorenzo Masia, Juergen Konczak, Giulio Sandini, Leonardo Cappello
  • Patent number: 10848375
    Abstract: The concepts and technologies disclosed herein are directed to a network-assisted Raft consensus protocol, referred to herein as “NetRaft.” According to one aspect of the concepts and technologies disclosed herein, a system can include a plurality of servers operating in a server cluster, and a plurality of P4 switches corresponding to the plurality of servers. Each server of the plurality of servers can include a back-end that executes a complete Raft algorithm to perform leader election, log replication, and log commitment of a Raft consensus algorithm. Each P4 switch of the plurality of P4 switches can include a front-end that executes a partial Raft algorithm to perform the log replication and the log commitment of the Raft consensus algorithm. The back-end can maintain a complete state for responding to requests that cannot be fulfilled by the front-end. The requests can include read requests and/or write requests.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: November 24, 2020
    Assignees: AT&T Intellectual Property I, L.P., Regents of the University of Minnesota
    Inventors: Bo Han, Vijay Gopalakrishnan, Marco Platania, Zhi-Li Zhang, Yang Zhang
  • Patent number: 10843267
    Abstract: Heat exchangers are manufactured by three-dimensional (3D) printers by printing subsequent layers of a material in a print direction. The heat exchangers include one or more tubes. The one or more tubes are configured to transport a fluid to be heated or cooled. Each of the one or more tubes defines a slope that is within a threshold angle of the print direction. The heat exchangers include a plurality of fins that are each configured to intersect with the one or more tubes while allowing fluid flow between the plurality of fins to heat or cool the fluid. Each fin of the plurality of fins defines a slope that is within a threshold angle of the print direction.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: November 24, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Jane H. Davidson, Susan C. Mantell, Brandon J. Hathaway, Kunal Sudam Garde
  • Patent number: 10837802
    Abstract: A position sensing system for measuring a position of a linearly moving object includes a high magnetic permeability material positioned on the moving object, an electromagnet configured to generate an alternating magnetic field, and at least one magnetic sensor configured to measure an intensity of a first magnetic field that is based on the alternating magnetic field. A controller is configured to estimate a linear position of the moving object based on the measured intensity of the first magnetic field.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: November 17, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Heng Wang, Rajesh Rajamani, Ryan Madson
  • Patent number: 10837830
    Abstract: In general, an imaging system to synchronously record a spatial image and a spectral image of a portion of the spatial image is described. In some examples, a beam splitter of the imaging system splits an optical beam, obtained from a viewing device, into a first split beam directed by the imaging system to a spatial camera and a second split beam directed by the imaging system to the entrance slit of an imaging spectrograph that is coupled to a spectral camera. An electronic apparatus synchronously triggers the spatial camera and the spectral camera to synchronously record a spatial image and a spectral image, respectively.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: November 17, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Robert Vince, Swati Sudhakar More, James Melvin Beach
  • Patent number: 10831936
    Abstract: A system includes a user interface, a processor, and a memory. The user interface is configured to receive a user input and is configured to depict a first graphical representation of a device having a first configuration corresponding to a first simulation. The processor, coupled to the user interface, is configured to select a second simulation from a plurality of discrete simulations. The second simulation corresponds to the user input. The memory, coupled to the processor, is configured to store the plurality of discrete simulations. Each simulation includes device design parameters and corresponding performance parameters. The plurality of discrete simulations includes the first simulation and includes the second simulation. The processor is configured to generate a second graphical representation of the device having a second configuration and configured to depict the second graphical representation using the user interface. The second configuration is determined using the second simulation.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 10, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Arthur G. Erdman, Daniel F. Keefe, Dane Coffey
  • Patent number: 10833557
    Abstract: A motor includes a rotor used in conjunction with a stator to produce a magnetic field in the air gap having p pole pairs, wherein a single cross section of the rotor taken orthogonal to an axis of rotation comprises iron having a structure forming p teeth. The stator has at least one stator winding configured to form p pole pairs to produce a first magnetic field to rotate the rotor about the axis of rotation and configured to produce a second magnetic field of either one pole pair or p±1 pole pairs to create forces radial to the axis of rotation. The at least one stator winding has two sets of terminals, a first set of terminals for carrying current that produces the first magnetic field in the air gap having p pole pairs to rotate the rotor about the axis of rotation and a second set of terminals for carrying current that produces the second magnetic field in the air gap having either one pole pair or p±1 pole pairs to create the forces radial to the axis of rotation.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: November 10, 2020
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventor: Eric Severson
  • Patent number: 10821565
    Abstract: Methods of manufacturing a 3D micro-scale structure. A 2D net including a plurality of panels and a plurality of hinges is provided. The panels are arranged in a pattern. The hinges interconnect immediately adjacent ones of the panels within the pattern. An energy source remote from the 2D net is powered to deliver energy to the 2D net. The delivered energy triggers the 2D net to self-fold into a 3D micro-scale structure. The delivered energy creates an eddy current within at least one component of the 2D net, with the eddy current generating heat sufficient to melt at least one of the hinges. The melting hinge causes the corresponding panels to fold or pivot relative to one another. In some embodiments, the energy source is a microwave energy source. In other embodiments, the energy source delivers a magnetic field.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: November 3, 2020
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Chao Liu, Jeong-Hyun Cho
  • Patent number: 10821287
    Abstract: Described here are bioelectric modulation systems and methods for generating rotating or spatially-selective electromagnetic fields. A modulation system includes a multichannel electrode with independently controllable electrode channels that can be operated to generate rotating electromagnetic fields that stimulate cells regardless of their orientation, or to generate spatially-selective electromagnetic fields that preferentially stimulate cells oriented along a particular direction. The bioelectric modulation system may be implemented for stimulation of neurons or other electrically active cells. The bioelectric modulation described here may be used for a variety applications including deep brain stimulation (DBS), spinal cord and vagus nerve stimulation, stimulation of myocardial (heart) tissue, and directional stimulation of muscles.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: November 3, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Shalom Michaeli, Silvia Mangia, Olli Grohn, Artem Shatillo, Lauri Lehto, Matthew Johnson, Simeng Zhang, Julia Slopsema
  • Patent number: 10820818
    Abstract: A system and method for non-invasively generating a report of cardiac electrical activities of a subject includes determining, using cardiac electrical activation information, equivalent current densities (ECDs). The ECDs are assembled into time-course ECD information and a spectrum of the time-course ECD information is analyzed to determine peaks for spectral characteristics of atrial fibrillation (AF). The spectral characteristics of AF are correlated with potential electrical sources of the AF and a report is generated indicating the potential electrical sources of the AF spatially registered with the medical imaging data.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: November 3, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Bin He, Zhaoye Zhou
  • Patent number: 10822318
    Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1, R2, R3, R4, L1, L2 and Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful for labeling penicillin-binding proteins (PBPs).
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: November 3, 2020
    Assignees: Regents of the University of Minnesota, Indiana University Research and Technology Corporation
    Inventors: Erin Elizabeth Carlson, Shabnam Sharifzadeh, Alireza Shokri, Ozden Kocaoglu, Clayton L. Brown, Jr.
  • Patent number: 10816492
    Abstract: Assays used in conjunction with a thermal contrast reader are disclosed. In the assay, the test strip includes materials that can develop a thermal response if a target analyte is present in a sample. Linear flow assays include nanoparticles with high affinity binding to the analyte. Binding of the nanoparticles with an analyte in the sample is detected using thermal contrast. Analytes over a broad range of concentrations are detected in the linear flow assays. Methods of detecting target analytes and kits comprising lateral flow assays and thermal contrast reader are also disclosed.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: October 27, 2020
    Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: John C. Bischof, Zhenpeng Qin, Warren Chan, Taner Akkin, Li Zhan
  • Patent number: 10815123
    Abstract: An engine system for internal combustion and reformation of a fuel includes an engine, and a reforming reactor. The engine comprising an intake manifold for receiving a first fuel and an exhaust manifold for releasing an exhaust gas. The reforming reactor includes a first end portion, a second end, a wall having an outer surface and an inner surface. The inner surface defines an interior cavity for receiving the first fuel, a second fuel, reactants for the first fuel, or combinations thereof. The exhaust manifold of the system is sized and shaped for receiving a portion of the reforming reactor such that the exhaust gas flows along a surface of the reforming reactor within the exhaust manifold.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: October 27, 2020
    Assignee: Regents of the University of Minnesota
    Inventor: William Northrop
  • Patent number: 10813956
    Abstract: Provided herein are genetically modified microbes. In one embodiment, a genetically modified microbe includes an exogenous polynucleotide that includes a pheromone-responsive region. In one embodiment, the pheromone-responsive region is derived from a conjugative plasmid from a member of the genus Enterococcus spp. The pheromone-responsive region includes a pheromone-responsive promoter and an operably linked coding region encoding an antimicrobial peptide. In one embodiment, a genetically modified microbe includes an exogenous polynucleotide that includes a promoter and an operably linked coding sequence encoding an antimicrobial peptide, where expression of the coding region is controlled by a modulator polypeptide and is altered by a modulating agent, and where the coding region encodes an antimicrobial peptide. Also provided herein are methods of using the genetically modified microbes, including methods for inhibiting growth of an Enterococcus spp., a pathogenic E. coli, or a pathogenic Salmonella spp.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: October 27, 2020
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Yiannis J. Kaznessis, Katherine G. Volzing, Juan Borrero Del Pino, Gary Dunny
  • Patent number: 10813776
    Abstract: Embodiments relate to stents for supporting an airway or other duct or plenum. The stents can be rapidly customized and inserted into the airway, obviating the need for subsequent intubation or for invasive procedures.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: October 27, 2020
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: András Nemes, Robroy MacIver, Filippo Coletti
  • Publication number: 20200332020
    Abstract: The present invention relates to diagnostic and therapeutic agents comprising recombinant antibody fragments to bind a protein associated with cancer and methods of use of these diagnostic and therapeutic agents.
    Type: Application
    Filed: January 16, 2020
    Publication date: October 22, 2020
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Jayanth Panyam, Stephen Kalscheuer, Vidhi D. Khanna
  • Patent number: 10808084
    Abstract: A method includes reacting a polymer derived from a lactone with a cyclic carbonate compound comprising 2 to 5 cyclic carbonate moieties and a catalyst to form a crosslinked polylactone elastomer.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: October 20, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Jacob Paul Brutman, Deborah Kay Schneiderman, Marc Andrew Hillmyer, Guilhem Xavier De Hoe
  • Publication number: 20200325136
    Abstract: The invention provides a method for stimulating an immune response in an animal with a compound of formula: or a pharmaceutically acceptable salt thereof, wherein R1-R3, Ra, and Rb have any of the values defined herein.
    Type: Application
    Filed: June 22, 2020
    Publication date: October 15, 2020
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventor: David Ferguson
  • Patent number: 10799573
    Abstract: Bordetella pertussis iron receptor proteins or portions thereof (e.g., one or more extracellular domains), alone or spliced into B. pertussis scaffold proteins (e.g., fimbrial or flagellin), are provided and can be used in acellular vaccines to protect against pertussis or other Bordetella diseases in humans and non-human mammals. In addition, Bordetella species grown under iron-starved conditions are provided and can be used in whole cell vaccines to protect against pertussis or other Bordetella diseases in humans and non-human mammals.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: October 13, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Timothy Joseph Brickman, Sandra Kay Armstrong