Patents Assigned to Regent of the University of Minnesota
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Patent number: 4665829Abstract: The guideway is comprised of upper horizontal stringers (20, 22), lower horizontal stringers (24, 26) vertically oriented diagonal members (30, 32) affixed to the upper and lower horizontal stringers (20, 22 and 24, 26) and horizontally oriented diagonal members (34) are affixed between the lower horizontal stringers (24, 26). These features present a guideway having an upwardly extending U-shape construction which can be supplied with wheel supporting channels (28), upper support channels (35) and the entire structure can be reinforced by ribs (60) and enclosed by a cover (50). The ribs include spaced inner and outer members with joined free ends.Type: GrantFiled: July 28, 1986Date of Patent: May 19, 1987Assignee: Regents of the University of MinnesotaInventor: J. Edward Anderson
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Patent number: 4665830Abstract: A vehicle supporting guideway is presented, the guideway is comprised of upper horizontal stringers, lower horizontal stringers vertically oriented diagonal members affixed to the upper and lower horizontal stringers and horizontally oriented diagonal members are affixed between the lower horizontal stringers. These features present a guideway having an upwardly extending U-shape construction which can be supplied with wheel supporting channels, and upper support channels. The entire structure is reinforced by ribs which are generally within the horizontal stringers, and the entire guideway may be enclosed by a cover. Overlapping members join adjacent sections of the horizontal stringers together.Type: GrantFiled: June 7, 1985Date of Patent: May 19, 1987Assignee: Regents of the University of MinnesotaInventors: J. Edward Anderson, Donald C. Sassor
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Patent number: 4661257Abstract: Quaternary ammonium salts are disclosed which are highly effective as complexing agents for the extraction of hydrogen ion and anions such as nitrate from an aqueous feed solution via a coupled ion transport mechanism employing supported liquid membranes.Type: GrantFiled: March 13, 1985Date of Patent: April 28, 1987Assignee: Regents of the University of MinnesotaInventors: Maurice M. Kreevoy, Ann T. Kotchevar
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Patent number: 4657536Abstract: A catheter having a tip which is resistant to plugging by blood components or other body fluids when used as a long term implant within a living body. A check valve is incorporated in the tip that is exposed to the blood stream or other body fluids. The central bore within the catheter is closed at its downstream end. A cross bore or port is provided immediately upstream from the closed end. This cross bore is covered by a thin elastic sleeve to create a check valve. The pressure developed by injected infusate through the catheter opens the valve against the elastic force of the outer sleeve. Fluids cannot enter the catheter either by diffusion against the high velocity exit flow or by suction applied to the proximal end of the catheter.Type: GrantFiled: March 19, 1981Date of Patent: April 14, 1987Assignee: Regents of the University of MinnesotaInventor: Frank D. Dorman
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Patent number: 4652521Abstract: A method for the early diagnosis of Bordetella diseases based on the detection of Bordetella adenylate cyclase and the ability of this enzyme to catalyze the formation of cyclic adenosine monophosphate (cAMP). A sample secretion is taken from a suspected victim of a Bordetella disease (the most common of which in humans is whooping cough) and incubated under conditions to promote the formation of cAMP, which may then be measured as evidence of the presence of the disease. A sample of nasopharyngeal secretions is maintained in a nutrient medium pending assay. An adenylate cyclase assay is made by incubating the sample with adenosine triphosphate (ATP) and the calcium binding protein calmodulin to generate cAMP. The cAMP is measured by any of several known available methods.Type: GrantFiled: March 4, 1985Date of Patent: March 24, 1987Assignee: Regents of the University of MinnesotaInventors: Dennis L. Confer, John W. Eaton
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Patent number: 4652261Abstract: A drug-injection animal collar includes electrically operated drug injection darts or syringes that are controlled by control circuitry mounted on the collar which may be preset and self-timed and actuated, or may be remotely actuated by radio signals. The collar is placed on the neck of an animal and upon receipt of a signal, a suitable drug is injected into the neck muscles of the animal. The collar and its method of operation allow regular recapture of individual animals at will for research purposes. The collar and darts may be reconditioned and then reused. The power for operation is also contained in the control package carried by the collar.Type: GrantFiled: June 22, 1984Date of Patent: March 24, 1987Assignee: Regents of the University of MinnesotaInventors: L. David Mech, Richard C. Chapman, William W. Cochran
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Patent number: 4650754Abstract: A method for quantitatively determining the extent of mold contamination of grain and other mold-susceptible bulk food. The mold spores are selectively extracted from a small representative sample of the grain or other food by admixing with a solvent. After washing with a detergent, the extracted spores are suspended in a sterile solution and, in the case of heavy contamination, a series of graduated dilutions of known concentration are prepared. A measured sample of suspended spores is transferred to a nutrient growth medium and maintained under growth conditions until all possible spore colonies have developed. The spore colonies are counted. Since the dilution factor is known, the number of fungal spores in the original sample of stored product can readily be calculated.Type: GrantFiled: October 2, 1984Date of Patent: March 17, 1987Assignee: Regents of the University of MinnesotaInventor: Robert M. Brambl
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Patent number: 4649200Abstract: Substituted pyrroles of the formula: ##STR1## are disclosed wherein R.sup.1 is (C.sub.1 -C.sub.5)alkyl, C.sub.3 -C.sub.6 (cycloalkyl) alkyl, C.sub.5 -C.sub.7 (cycloalkenyl)alkyl, aryl, aralkyl, trans-(C.sub.4 -C.sub.5) alkenyl, allyl or furan-2-ylalkyl; R.sup.2 is H or OH, R.sup.3 is H, (C.sub.1 -C.sub.5)alkyl or (C.sub.1 -C.sub.5)alkanoyl and R.sup.4 is H or (C.sub.1 -C.sub.5) alkyl; as well as the pharmaceutically-acceptable salts thereof. These compounds are useful as analgesics and/or as selective kappa-opioid antagonists.Type: GrantFiled: May 8, 1986Date of Patent: March 10, 1987Assignee: Regents of the University of MinnesotaInventors: Philip S. Portoghese, Andrzej W. Lipkowski
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Patent number: 4644675Abstract: A page turner device for an open book comprises a support for the book, and a power driven disc configured to rest on the top of the pages of such open book. When the power drive is energized, the disc will start to rotate while in contact with the open pages. The disc has a finger portion which protrudes outwardly from adjacent portions of the disc, and a page curler drive is used for creating a curl or arch in the center portions of an open page, so that when the finger rotates to the proper position, it will go into the recess under the curl, and as it continues to rotate, the finger will pull the page with it. When the disc comes to a rest position, the finger will have completely opened the subsequent page. At the rest position a cam operates a switch to disable the power drive until such time as the person reading again initiates a manual switch to commence the page turning sequence.Type: GrantFiled: February 11, 1985Date of Patent: February 24, 1987Assignee: Regents of the University of MinnesotaInventors: John G. Berger, David J. Emmons
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Patent number: 4646002Abstract: A zero capacitance measurement probe to be used to make electrical measurements at a broad range of frequencies without having the probe itself affect the measured values. The probe reduces internal capacitances in the solid state active elements or creates a negative impedance to counteract capacitance external capacitance. Elimination of capacitance is accomplished by adjusting gains and current flow within active elements and by insulating the elements from ground by an additional substrate and metalized layer.Type: GrantFiled: May 10, 1984Date of Patent: February 24, 1987Assignee: Regents of the University of MinnesotaInventor: Alfons A. Tuszyski
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Patent number: 4644943Abstract: A bone fixation device for securing adjacent and separated bone portions, such as at a joint or at a relatively clean, unsplintered break, comprises a pair of telescoping members which are pinned into the respective bone portions, and have internal actuating members to permit the telescoping parts to be moved together to bring the two bone portions to bear against one another at a desired level of pressure. After the telescoping members have been adjusted the members are permanently left in place to fix and hold the joint or break in a predetermined relationship. The adjusting members also remain in place as pins within the bone, which are accessible through incisions in the skin if later adjustment is necessary. The entire device is embedded, and is not external. The process of inserting is relatively simple to follow and rigidly fixes a joint or break between two abutting bone portions without having external members.Type: GrantFiled: July 20, 1984Date of Patent: February 24, 1987Assignee: Regents of the University of MinnesotaInventors: Roby C. Thompson, Arthur G. Erdman, Frank D. Dorman
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Patent number: 4644782Abstract: A transparent cylinder is filled with two liquids of different densities and is sealed at both ends. A rod, having a diameter smaller than the inner diameter of the cylinder is mounted on the longitudinal axis of the cylinder. The filled cylinder is mounted horizontally between two end supports and rotated about the longitudinal axis of the cylinder. The less dense liquid will form around the rod at an appropriate speed, and when steady state equilibrium is achieved by the liquids inside the cylinder, the diameter of the less dense liquid and the rotational speed of the cylinders are measured.Type: GrantFiled: February 13, 1986Date of Patent: February 24, 1987Assignee: Regents of the University of MinnesotaInventor: Daniel D. Joseph
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Patent number: 4636217Abstract: A spinal implant prosthetic insert for implantation into a void in the spinal column in place of a diseased or injured vertebra that has been removed. The insert maintains the height of the anterior spinal column, thus preventing deformity from occurring. The prosthesis insert is implanted into the spinal column after the anterior vertebral body has been removed. The insert is rigidly fixed in place with bone screws that will screw into the adjacent upper and lower vertebrae after the insert has been positioned in place, through the operation of a drive that is accessible after the insert has been implanted into place. The insert is contoured so that no substantial part of it protrudes outside of the margins of the anterior vertebral column, making it usable as an implant even in the lumbar region where protrusions from the spinal column cannot be tolerated.Type: GrantFiled: April 23, 1985Date of Patent: January 13, 1987Assignee: Regents of the University of MinnesotaInventors: James W. Ogilvie, Frank R. Ogilvie
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Patent number: 4630535Abstract: A method and apparatus for more effectively squeezing moisture from wood chips and/or other "green" biomass materials. A press comprising a generally closed chamber having a laterally movable base at the lower end thereof, and a piston or ram conforming in shape to the cross-section of the chamber is adapted to periodically receive a charge of biomass material to be dehydrated. The ram is forced against the biomass material with suffcient force to compress the biomass and to crush the matrix in which moisture is contained within the material with the face of the ram being configured to cause a preferential flow of moisture from the center of the mass outwardly to the grooved walls of the chamber. Thus, the moisture is effectively squeezed from the biomass and flows through the grooves formed in the walls of the chamber to a collecting receptacle and is not drawn back into the mass by capillary action when the force is removed from the ram.Type: GrantFiled: October 12, 1984Date of Patent: December 23, 1986Assignee: Regents of the University of MinnesotaInventor: John G. Haygreen
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Patent number: 4627444Abstract: A device and process for sampling tissue and fluid from bodily cavities comprises an aspirating curette or catheter with at least one notch at its distal end to provide edges for a scraping action sufficient to loosen tissue from the wall of a bodily cavity. The aspirating curette is slidably mounted in and encased by a protective sleeve that has a contamination preventing plug at its outer end. The protective sleeve is shorter than the curette and a removable stop member is provided to initially limit the movement of the protective sleeve toward the base of the curette. When the protective sleeve and curette have been inserted into the bodily cavity the stop is removed, permitting the aspirating curette to be moved outwardly through the protective sleeve, dislodging the plug and exposing the notch in the curette. Fluids may be drawn into the aspirating curette which is then rotated to scrape the cavity wall, and the curette is drawn back into the protective sleeve.Type: GrantFiled: June 20, 1985Date of Patent: December 9, 1986Assignee: Regents of the University of MinnesotaInventor: Doris C. Brooker
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Patent number: 4626271Abstract: An herbicidal composition comprising cyanobacterin and a surfactant. Cyanobacterin obtained from extracts of blue-green algae or chemical synthesis when combined with a sticker such as non-ionic surfactants provides an heribicidal formulation which will adhere to green plants in a herbicidally effective amount.Type: GrantFiled: September 17, 1985Date of Patent: December 2, 1986Assignee: The Regents of the University of MinnesotaInventor: Florence K. Gleason
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Patent number: 4621591Abstract: A combination collar and muzzle is used as a humane method of restraining, controlling, and achieving obedient behavior of animals, dogs in particular. A collar member or loop encircles the neck immediately behind the ears, and a second loop encircles the upper and lower jaws of the animal to form a type of a figure eight combination collar and muzzle. The two loops are coupled together with a ring behind the jaw. The loops are slidably connected so that when a leash is attached to the portion of the muzzle loop extending out from the connecting ring it will slide easily and at the same time will exert a downward pressure on the neck immediately behind the ears. Pressure is thus simultaneously applied to nerves and muscles tending to control the dog humanely and without choking or applying pressure to the trachea and larynx.Type: GrantFiled: April 4, 1985Date of Patent: November 11, 1986Assignee: Regents of the University of MinnesotaInventors: Robert K. Anderson, Ruth E. Foster, Jeffrey A. Levine
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Patent number: 4605644Abstract: The perfusion of ischemic tissue with dilute physiological salt solutions containing adenine and ribose reduces the period required for tissue function recovery and for the restoration of tissue of ATP levels.Type: GrantFiled: February 7, 1985Date of Patent: August 12, 1986Assignee: Regents of the University of MinnesotaInventor: John E. Foker
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Patent number: 4602502Abstract: A wave speed meter comprises a pair of relatively rotatable, concentric cylinders with a gap between the cylinders to define a chamber. A viscoelastic fluid is placed in the chamber, and one of the cylinders is suddenly rotationally displaced causing a shear induced wave to be propagated through the fluid filling the chamber between the cylinders. This wave is propagated toward the other cylinder and when the wave reaches the other cylinder the other cylinder moves. The transit time of the wave is determined by measuring the time between the displacement of the one cylinder and movement of the other cylinder as a result of the wave. The distance that the wave travels is known, so that the wave speed can be determined.Type: GrantFiled: January 22, 1985Date of Patent: July 29, 1986Assignee: Regents of the University of MinnesotaInventors: Daniel D. Joseph, Oliver Riccius
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Patent number: 4595609Abstract: Substrates having free surface hydroxyl groups, such as silaceous and aluminous materials, are rendered corrosion resistant by the application thereto of an amorphous, homogeneous tantalum pentaoxide coating layer.Type: GrantFiled: November 21, 1984Date of Patent: June 17, 1986Assignee: Regents of the University of MinnesotaInventors: Stephen T. Wellinghoff, Ching Lin