Patents Assigned to Regents at The University of Michigan
  • Pharmaceutical compounds and use of same in cancer and tauopathies
    Patent number: 9808448
    Abstract: Disclosed are compounds of formula (l)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. Tau is a microtubule-binding protein that accumulates in a number of neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease (AD). The presence of abnormal tau correlates with neuron loss and memory deficits in patients with AD and other neurodegenerative disorders that involve tau accumulation.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: November 7, 2017
    Assignees: REGENTS OF THE UNIVERSITY OF MICHIGAN, UNIVERSITY OF SOUTH FLORIDA
    Inventors: Jason E. Gestwicki, Chad Dickey
  • Resistive memory structure for single or multi-bit data storage
    Patent number: 9805791
    Abstract: A resistive memory structure comprises at least one resistive memory element configured to store one or more bits of data and a circuit electrically connected to the resistive memory element for use in performing at least one of a read or write operation on the at least one resistive memory element. The circuit includes a resistor electrically connected in series to the resistive memory element thereby forming a voltage divider and electrical node therebetween, and an interpretation circuit electrically connected to the electrical node formed between the resistive memory element and the resistor. The interpretation circuit is configured to interpret a voltage at the electrical node and to determine a resistive state of the resistive memory element based on the voltage at the electrical node.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: October 31, 2017
    Assignee: The Regents of the University of Michigan
    Inventors: Yalcin Yilmaz, Pinaki Mazumder
  • Photoconductive emitter device with plasmonic electrodes
    Patent number: 9804026
    Abstract: A photoconductive device that includes a semiconductor substrate, an antenna assembly, and a photoconductive assembly with one or more plasmonic contact electrodes. The photoconductive assembly can be provided with plasmonic contact electrodes that are arranged on the semiconductor substrate in a manner that improves the quantum efficiency of the photoconductive device by plasmonically enhancing the pump absorption into the photo-absorbing regions of semiconductor substrate. In one exemplary embodiment, the photoconductive device is arranged as a photoconductive source and is pumped at telecom pump wavelengths (e.g., 1.0-1.6 ?m) and produces milliwatt-range power levels in the terahertz (THz) frequency range.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: October 31, 2017
    Assignee: The Regents of the University of Michigan
    Inventors: Mona Jarrahi, Christopher W. Berry, Shang-Hua Yang
  • Nanoemulsion therapeutic compositions and methods of using the same
    Patent number: 9801842
    Abstract: The present invention relates to methods and compositions for treating pulmonary infection. In particular, the present invention provides nanoemulsion compositions and methods of using the same to treat bacteria associated with biofilms (e.g., found in pulmonary infections). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: October 31, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James R. Baker, Jr., Sivaprakash Rathinavelu, Paul E. Makidon, John J. LiPuma, Shraddha Nigavekar
  • Baulamycins, compositions and methods of use thereof
    Patent number: 9803187
    Abstract: Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of Streptomyces tempisquensis.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: October 31, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ASOCIACION INSTITUTO NACIONAL DE BIODIVERSIDAD
    Inventors: David H. Sherman, Ashootosh Tripathi, Michael Marie Kaufman-Schofield, Giselle Tamayo, Pam Schultz
  • Compositions and methods of treating cancer
    Patent number: 9801922
    Abstract: The invention provides compositions and methods to treat cancer with an agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria (“an XTPP agent”) or a pharmaceutically acceptable salt thereof, an inhibitor of hydroperoxide metabolism and a pharmaceutically acceptable diluent or carrier.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: October 31, 2017
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Douglas R. Spitz, Michael K. Schultz, Kyle Kloepping, Yueming Zhu, Nukhet Aykin-Burns, Max S. Wicha
  • Ultrafiltration membrane device, bioartificial organ, and related methods
    Patent number: 9802158
    Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: October 31, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE CLEVELAND CLINIC FOUNDATION
    Inventors: William H. Fissell, Shuvo Roy, Aaron Fleischman, Kenneth G. Goldman
  • SYSTEMS AND METHODS FOR MEASURING WAVE FIELDS OF A BODY OF WATER
    Publication number: 20170307748
    Abstract: This disclosure relates to systems and methods for measuring wave fields of a body of water. A system can include a radiation source and an antenna that can cooperate with the radiation source to transmit a radio frequency (RF) signal to a wave field having one or more waves. The antenna can receive backscattered signals from the wave field. The system can include a local oscillator and a processor. The local oscillator downconverts the backscattered signals into baseband signals and the processor can process the baseband signals to determine a relative velocity of each of the waves of the wave field. The processor can further be programmed to identify an observed portion of the backscattered signals as bad data and remove the bad data from further processing.
    Type: Application
    Filed: April 21, 2017
    Publication date: October 26, 2017
    Applicants: Ohio State Innovation Foundation, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Joel Johnson, Andrew O'Brien, David Lyzenga, Graeme Smith, Shanka N. Wijesundara
  • Multi-mode separation for target detection
    Patent number: 9797817
    Abstract: Sandwich separation is based on forming a sandwich complex with a magnetic bead, buoyant bead, and a target. Once a sandwich formation is created, the sandwich can be separated using its dual physical properties, namely magnetism and buoyancy. Sandwich separation is highly specific, allows for removal of the beads that do not have any attached target, and reduces the number of background beads. Sandwich separation can also be used to allow for target detection in raw specimen. Also, improvement of detection capability is accomplished by performing AMBR measurements on a solid interface, where the rotational period speeds up and allows for dramatically reduced time-to-result.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: October 24, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Brandon H. McNaughton, Paivo Kinnunen, John G. Younger
  • Moving-sum charge pump
    Patent number: 9800143
    Abstract: Various implementations described herein are directed to an integrated circuit. The integrated circuit may include a charge pump stage having multiple charge storage elements arranged to provide multiple sets of voltages in alternating phases. The integrated circuit may include a voltage multiplexing stage having multiple multiplexers arranged to receive the multiple sets of voltages in the alternating phases. Each multiplexer may provide a selected voltage from the multiple sets of voltages based on a conversion ratio. The integrated circuit may include a voltage summing stage having multiple sampling charge storage elements arranged to receive the selected voltages from each multiplexer and provide an output voltage as a sum of the selected voltages received from each multiplexer.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 24, 2017
    Assignee: The Regents of the University of Michigan
    Inventors: Xiao Wu, David Theodore Blaauw, Dennis Michael Chen Sylvester
  • Three dimensional microstructures and fabrication process
    Patent number: 9796586
    Abstract: A method for fabricating three-dimensional microstructures is presented. The method includes: disposing a substantially planar reflow material between two molds; heating the reflow material while the reflow material is disposed between the two molds; and reflowing the reflow material towards the bottom surface of one of the molds by creating a pressure gradient across the reflow material. At least one of molds includes geometrics features that help to shape the reflow material and thereby form a complex three-dimensional microstructure.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: October 24, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Khalil Najafi, Tal Nagourney, Jae Yoong Cho
  • Nozzle geometry for organic vapor jet printing
    Patent number: 9797039
    Abstract: A first device is provided. The device includes a print head. The print head further includes a first nozzle hermetically sealed to a first source of gas. The first nozzle has an aperture having a smallest dimension of 0.5 to 500 microns in a direction perpendicular to a flow direction of the first nozzle. At a distance from the aperture into the first nozzle that is 5 times the smallest dimension of the aperture of the first nozzle, the smallest dimension perpendicular to the flow direction is at least twice the smallest dimension of the aperture of the first nozzle.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: October 24, 2017
    Assignee: The Regents of the University of Michigan
    Inventors: Stephen R. Forrest, Gregory McGraw
  • Stem cell factor inhibitor
    Patent number: 9790272
    Abstract: Provided herein are methods, compositions, and uses relating to inhibitors of stem cell factor. For example, provided herein are antibodies targeting stem cell factor and methods for treating fibrotic and tissue remodeling diseases.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: October 17, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Nicholas W. Lukacs, Vladislav A. Dolgachev, Steven L. Kunkel, Cory M. Hogaboam, Sem H. Phan
  • Wireless power transfer using multiple near-field plates
    Patent number: 9793720
    Abstract: A near-field plate is a non-periodically patterned surface that can overcome the diffraction limit and confine electromagnetic fields to subwavelength dimensions. By controlling the interference of the electromagnetic fields radiated by the near-field plate with that of a source, the near-field plate can form a subwavelength near-field pattern in a forward direction, while suppressing fields in other directions, such as those reflected. The resulting unidirectional near-field plate may find utility in many applications such as high resolution imaging and probing, high density data storage, biomedical targeting devices, and wireless power transfer.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: October 17, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Anthony Grbic, Steve Young
  • Double-sided LCC compensation method for wireless power transfer
    Patent number: 9789777
    Abstract: A double-sided LCC compensation network and a tuning method are proposed for a wireless power transfer system. With the proposed topology, the resonant frequency is independent of coupling coefficient and load conditions. The parameter values are tuned to realize zero voltage switching (ZVS) for the sending side switches. A wireless charging system with up to 7.7 kW output power was designed and built using the proposed topology and achieved 96% efficiency from DC power source to battery load.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: October 17, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Chris Mi, Junjun Deng, Trong-Duy Nguyen, Weihan Li, Siqi Li
  • Patterning by stamped metal resist
    Patent number: 9793481
    Abstract: A method is provided. A first layer is provided over a substrate, the first layer comprising a first material. A patterned second layer is applied over the first layer via stamping. The second layer comprising a second material. The second layer covers a first portion of the first layer, and does not cover a second portion of the first layer. The second portion of the first layer is removed via a subtractive process while the first portion of the first layer is protected from removal by the patterned second layer.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: October 17, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Stephen R. Forrest, Momchil T. Mihnev, Andre D. Taylor, Xin Xu
  • Method of MRI imaging using non-slice-selective, spatially tailored tip-up pulse
    Patent number: 9791530
    Abstract: A method of acquiring image data with an MRI system from an object using a sequence of tip-down and tip-up RF pulses is described. A slice-selective first pulse ? rotates the in-slice spins from the longitudinal axis (z) toward a transverse plane (x, y). Image data is acquired from the in-slice spins during a free precession interval (Tfree) in which the in-slice spins precess along the transverse plane (x, y). A spatially tailored, non-slice-selective second pulse ?({right arrow over (r)}) is applied for rotating the in-slice spins from the transverse plane (x, y) to at least substantially along the longitudinal axis (z). A third pulse S may be applied to the in-slice and out-of-slice spins to eliminate (spoil) residual transverse signal from out-of-slice spins.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: October 17, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jon-Fredrik Nielsen, Daehyun Yoon, Douglas C. Noll
  • Physical unclonable function using augmented memory for challenge-response hashing
    Patent number: 9787481
    Abstract: A technique is presented for performing a physical unclonable function (PUF) using an array of SRAM cells. The technique can be viewed as an attempt to read multiple cells in a column at the same time, creating contention that is resolved according to process variation. An authentication challenge is issued to the array of SRAM cells by activating two or more wordlines concurrently. The response is simply the value that the SRAM produces from a read operation when the challenge condition is applied. The number of challenges that can be applied the array of SRAM cells grows exponentially with the number of SRAM rows and these challenges can be applied at any time without power cycling.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: October 10, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Daniel E. Holcomb, Kevin Fu
  • Recurrent gene fusions in cancer
    Patent number: 9783853
    Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to gene fusions as diagnostic markers and clinical targets for cancer.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: October 10, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Arul Chinnaiyan, Yi-Mi Wu, Dan Robinson
  • Method and apparatus for suppressing background light in time of flight sensor
    Patent number: 9786252
    Abstract: A background light suppression apparatus and method capable of suppressing influences of background light in a depth sensor includes measuring output signals of sub pixels for a sub integration time shorter than a frame integration time; and integrating differences between the output signals after the sub integration time.
    Type: Grant
    Filed: August 12, 2013
    Date of Patent: October 10, 2017
    Assignees: Samsung Electronics Co., Ltd., The Regents of the University of Michigan
    Inventors: Jung Soon Shin, Seong Jin Kim, Euisik Yoon, Jihyun Cho