Abstract: Some embodiments described herein are directed to a trunk supporting exoskeleton for reducing muscle forces in a wearer's back during forward lumbar flexion. The trunk supporting exoskeleton can include a supporting trunk frame, a first thigh link, a second thigh link, an actuator, a shaft pulley, a housing pulley, a shaft line, and a housing line. The actuator can include an actuator housing and an actuator shaft. When the wearer is bent forward relative to a vertical gravitational line in a sagittal plane, the actuator can generate an actuator resistive torque between the actuator housing and the actuator shaft. The actuator resistive torque between the actuator housing and the actuator shaft can generate tensile forces in the housing line and the shaft line, thereby generating extension torques between the respective first and second thigh links and the supporting trunk frame.

Abstract: A foot evaluation device is configured to evaluate metrics of foot health accurately and precisely. The foot evaluation device includes a platform configured to accommodate a user's foot, and a toe sensor assembly that is removably attachable to the platform and includes a toe force sensor and a toe cap connected to the toe force sensor. The toe force sensor is configured to measure forces applied to the toe force sensor by a toe of the user's foot.

Abstract: An artificial intelligence enabled advanced treatment management system (AI-ATMS) is configured to improve inter-actions and outcomes from a multidisciplinary patient care team. The AI-ATMS includes advanced integration with an artificial intelligence system with access to federated databases. The AI-ATMS is configured for the real-time engagement with the patient-treatment team in a manner that provides the patient-treatment team with context-related data elements, while also permitting the patient-treatment team with the ability to train the AI-ATMS during the engagement. The AI-ATMS may be for treating a cancer or other medical condition.

Abstract: Systems and methods are provided for imaging and characterizing objects including the eye using non-uniform or speckle illumination patterns. According to the present technology, a method for characterizing at least a portion of an object may include generating, using at least one light source, one or multiple non-uniform illumination patterns on an object. The method may also include detecting, using a detector, backscattered light from the object in response to the generating. The method may further include extracting, using the detector, data representative of the backscattered light. The method may also include processing, using a processing unit, the data representative of the backscattered light to create one or more images of at least a portion of the object.

Abstract: The present invention provides for a composition comprising a purified or isolated Hyde1 gene product, or a functional fragment thereof; a modified host cell capable of expressing a Type VI secretion system (T6SS), Hyde1, and/or Hyde2, or a functional fragment thereof; a method of treating a disease caused all or in part by a bacterial cell, comprising administering a composition of the present invention to a subject in need thereof; and a method to limit or reduce growth of a pathogenic bacteria in an environment, comprising: introducing a non-pathogenic bacterial capable of expressing a Type VI secretion system (T6SS), Hyde1, and/or Hyde2, or functional fragment thereof, to an environment.

Abstract: Systems and methods to eliminate or reduce the foreign body response (FBR) that occurs when a medical device is implanted into a patient. The FBR causes a chronic inflammatory response that leads to the encapsulation of a medical device by a fibrous capsule. Macrophages have been discovered to become persistent as a result of the implanted biomaterial which occurs by an up-regulation in cFLIP. This persistence of macrophages appears to be the primary driver of the FBR. Re-sensitizing macrophages to apoptosis using a small molecule inhibitor (e.g., YM155) of cFLIP will abrogate the formation of the fibrous capsule in the FBR.

Abstract: Methods for diagnosing non-alcoholic steatohepatitis (NASH) and NASH with or without advanced liver fibrosis in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of NASH versus simple steatosis and NASH with advanced liver fibrosis versus NASH without advanced liver fibrosis. The invention also provides methods treating NASH (e.g., NASH with or without advanced liver fibrosis) by administering a biomarker or an agent that modulates a biomarker of NASH or fibrosis. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.

Abstract: A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.

Abstract: Systems and methods for detecting ?9-tetrahydrocannabinol (?9-THC) are described. In many embodiments, the detection of ?9-THC can be achieved by oxidizing ?9-THC to corresponding oxidized products. The oxidation of ?9-THC can be achieved chemically or electrochemically. The oxidized products of ?9-THC can exhibit different photophysical and electrochemical properties compared to ?9-THC. Many embodiments implement integrating ?9-THC detection into a multimodal marijuana breathalyzer device.

Abstract: A method, a system, and computer program product for degradation-aware training of neural networks are provided. A degradation of degraded memory cells of a memory array is detected, during a training of a neural network. A first set of writing parameter values to be applied to the one or more degraded memory cells and a second set of writing parameter values to be applied to the undegraded memory cells is determined using a model of the memory array tuned to account for the degradation of one or more memory cells. A writing operation is executed, by applying the first set of writing parameter values to the one or more degraded memory cells to compensate for the degradation of the one or more degraded memory cells and by applying the second set of writing parameter values to the undegraded memory cell.

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ?v?8 integrin. The invention includes uses, and associated methods of using the antibodies.

Abstract: An integrated vascular delivery system having a frame configured to receive a catheter insertable in a patient to deliver fluid at an insertion site. The frame includes a first hub, a second hub, and a pair of flexible lateral members extending between the hubs and including a tubular lateral member. The system also includes a fluidic channel that fluidically communicates with the catheter, wherein the fluidic channel passes through the tubular lateral member and at least one of the hubs, and includes a fixed turnabout portion in which fluid flows in a direction different from that within the catheter. The first and second hubs provide anchoring points on the patient distributed around the insertion site and on opposite ends of the catheter, thereby anchoring the frame to the patient and stabilizing the catheter. A method is provided for using an integrated vascular delivery system.

Abstract: Efficient condition optimization for the synthesis of highly branched polymers using high throughput screening has been developed. This innovation allows rapid production of soluble, highly branched polymers with different properties (molecular weight, degree of branching, etc.). Moreover, this versatile technique has the potential to be extended to other monomer/linker systems and polymerization techniques such as emulsion or suspension polymerization, anionic polymerization and continuous flow synthesis. A resin composition is further disclosed.

Abstract: In certain embodiments, a lentiviral vector for the treatment of sickle cell disease (SCD) is provided. In certain embodiments, the vector comprises an expression cassette that encodes that an anti-sickling ?-globin gene and an shRNA that inhibits expression of a BCL11A gene (BCL11A shRNA) wherein said expression cassette is in reverse orientation in the vector; a ?-globin locus control region (LCR) comprising a reduced length hypersensitive site 1 (HS1) sequence, a reduced length hypersensitive site 2 (HS2) sequence, a reduced length hypersensitive site 3 (HS3) sequence, and a reduced length hypersensitive site 4 (HS4) sequence, where said anti-sickling ?-globin gene is operably linked to the human ?-globin locus control region.

Abstract: The technology disclosed provides Furcifer: a framework capable of dynamically adapting the cloud continuum computing configuration in response to the perceived state of the system. Our container-based approach incorporates low-complexity predictors that generalize well across operating environments. In addition, we develop a highly optimized split Deep Neural Network model, which achieves in-model supervised compression and enhances task offloading. Experimental results for object detection across diverse conditions, environments, and wireless technologies, show Furcifer's remarkable outcomes, including a 2× energy reduction, 30% higher mean Average Precision score than pure local computing, and a notable three-fold increase in frame per second rate compared to static offloading.

Abstract: A monolithic gas chromatograph is presented. The monolithic gas chromatograph includes a separation column and a gas detector. The separation column has an inlet to receive a gas sample therein. The separation column resides in a first layer of an integrated chip. The gas detector has an ionization chamber and an ionization source. The ionization chamber has an inlet in fluid communication with an outlet of the separation column to receive a gas sample from the separation column. The ionization source is configured to ionize molecules of the gas sample residing in the ionization chamber. The gas detector resides in a second layer of the integrated chip. The monolithic gas chromatograph further includes a third layer disposed between the first layer and the second layer. The third layer is configured to electrically isolate the first layer from the second layer. The gas detector is fluidly coupled to the separation column.

Abstract: A heterogeneous energy storage device and a method for controlling a heterogeneous energy storage device are provided. In one implementation, a heterogeneous energy storage device is provided. The heterogeneous energy storage device includes a first energy storage device, a second energy storage device and a capacitive device. The first energy storage device has a first energy capacity and a first power to energy ratio (P/E). The second energy storage device has a second total energy capacity and a second P/E ratio different from the first P/E ratio. The capacitive device is coupled in series with the first energy storage device, wherein the second energy storage device is coupled in parallel with the series combination of the capacitive device and the first energy storage device. In another implementation, a method of controlling a heterogeneous energy storage device including a first energy storage device and a second energy storage device is provided.

Abstract: An organic photovoltaic device comprises an anode and a cathode, an active layer positioned between the anode and the cathode, comprising a first donor material and a first acceptor material in a first ratio, and an interface layer positioned between the anode and the cathode, comprising a second donor material and a second acceptor material in a second ratio. A method of fabricating an organic photovoltaic device and an organic photovoltaic device produced with the disclosed methods are also disclosed herein.

Abstract: The current methods and compositions provide for a novel and effective therapeutic method for treating opioid use disorder, opioid withdrawal symptoms and/or chronic pain. Accordingly, certain aspects of the disclosure relate to a method for treating opioid use disorder, opioid withdrawal symptoms and/or chronic pain in a subject, the method comprising administering at least one purified cannabinoid compound and a partial opioid agonist. In some embodiments, the method comprises administering a composition comprising cannabidiol and buprenorphine.

Abstract: In various embodiments deformable nano-scale vehicles (DNV) are provided that are useful for the delivery of therapeutic agents. In certain embodiments the DNVs are capable of transdermal delivery and can additionally cross the blood-brain barrier.