Patents Assigned to Regents of the University of California
  • Publication number: 20080204327
    Abstract: A dual-band resonator with compact size, such as a resonant type dual-band antenna, which uses an anisotropic metamaterial is described. The artificial anisotropic medium is implemented by employing a composite right/left-handed transmission line. The dispersion relation and the antenna physical size only depend on the composition of the unit cell and the number of cells used. By engineering the characteristics of the unit cells to be different in two orthogonal directions, the corresponding propagation constants can be controlled, thus enabling dual-band antenna resonances. In addition, the antenna dimensions can be markedly minimized by maximally reducing the unit cell size. A dual-band antenna is also described which is designed for operation at frequencies for PCS/Bluetooth applications, and which has a physical size of 1/18?0× 1/18?0× 1/19?0, where ?0 is the free space wavelength at 2.37 GHz.
    Type: Application
    Filed: August 23, 2007
    Publication date: August 28, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Cheng-Jung Lee, Kevin M.K.H. Leong, Tatsuo Itoh
  • Patent number: 7416550
    Abstract: A method of electroforming tissue comprises creating stress in the tissue; and causing a direct current to flow in the tissue to change the stress, strain, or intrinsic mechanical properties including shape of the tissue. Force is mechanically applied to the tissue to create external stresses or material parameters of the tissue are used to create internal stresses in the tissue by causing a current to flow in the tissue. The method further comprises the step of monitoring the stresses in the tissue and controlling the current flowing in the tissue according to the stresses therein by monitoring impedance, the optical properties, the pH, acoustic properties of the tissue, the gas formation in the tissue, the color of the tissue as caused by a chemical dye disposed therein or as caused by electroplating a material thereon.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: August 26, 2008
    Assignee: The Regents of the University of California
    Inventors: Dmitry E. Protsenko, Brian J. F. Wong, Guillermo Aguilar-Mendoza, Ki-Hong Kevin Ho, Sergio Diaz
  • Patent number: 7417113
    Abstract: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: August 26, 2008
    Assignees: The Regents of the University of California, Agensys, Inc.
    Inventors: Robert E. Reiter, Owen N. Witte, Arthur B. Raitano
  • Patent number: 7417468
    Abstract: A dynamic and differential CMOS logic style is disclosed in which a gate uses a fixed amount of energy per evaluation event. The gate switches its output at every event and loads a constant capacitance. The logic style is a Dynamic and Differential Logic (DDL) style. The DDL style logic typically has one charging event per clock cycle and the charging event does not depend on the input signals. The differential feature masks the in-put value because a precharged output nodes is discharged during the evaluation phase. The dynamic feature breaks the input sequence: the discharged node is charged during the subsequent precharge phase.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: August 26, 2008
    Assignee: The Regents of the University of California
    Inventors: Ingrid M. Verbauwhede, Kris J. V. Tiri
  • Publication number: 20080201808
    Abstract: An improved Prunus dulcis variety is provided that is well suited for serving as a replacement for the premium quality ‘Marcona’ variety (non-patented in the United States). A distinctive heart-shape kernel in combination with very high kernel lipid quality is displayed. Good bloom overlap is displayed with the widely-grown ‘Nonpareil’ variety (non-patented in the United States) and pollen is cross-compatible with ‘Nonpareil’ and all major California almond varieties. The tree exhibits an upright-spreading growth habit with good productivity. Desirable fruit and kernel characteristics for shelled and processed almond production are displayed.
    Type: Application
    Filed: February 15, 2007
    Publication date: August 21, 2008
    Applicant: The Regents Of The University of California
    Inventors: Thomas Gradziel, Mary Thorpe, Dale Kester, Nancy Baysinger
  • Publication number: 20080197929
    Abstract: Radio frequency/millimeter wave integrated circuits (RF/MMICs) that employ a resonance mechanism between an input stage and a transistor are disclosed. The circuits contain an input stage, a transistor; and a transformer connected between either a gate or a base of the transistor and a voltage supply of the input stage. The methods disclosed maximize either a collector current or a drain current of a transistor by placing a transformer between the transistor and a voltage source.
    Type: Application
    Filed: July 31, 2006
    Publication date: August 21, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Mau-Chung Frank Chang, Daquan Huang
  • Publication number: 20080199964
    Abstract: The present invention provides reagents and methods for the introduction of analogues of methyl or acetyl lysine into histone proteins.
    Type: Application
    Filed: December 20, 2007
    Publication date: August 21, 2008
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kevan Shokat, Matthew D. Simon
  • Publication number: 20080199863
    Abstract: Described are probes and methods for detecting pathogens and antibiotic resistance of a specimen. The method comprises contacting the specimen with a growth medium; and lysing the specimen to release nucleic acid molecules from the specimen. The lysate of the specimen is contacted with a capture probe immobilized on a substrate, wherein the capture probe comprises an oligonucleotide that specifically hybridizes with a first target nucleic acid sequence region of ribosomal RNA. The lysate is in contact with a detector probe that comprises a detectably labeled oligonucleotide that specifically hybridizes with a second target nucleic acid sequence region of ribosomal RNA. The presence or absence of labeled oligonucleotide complexed with the substrate is determined. Detection of labeled oligonucleotide complexed with the substrate is indicative of the presence of pathogen. Performing the method in the presence and absence of an antibiotic permits detection of antibiotic resistance.
    Type: Application
    Filed: May 1, 2007
    Publication date: August 21, 2008
    Applicants: The Regents of the University of California, U.S. Government represented by the Dept. of Veterans Affairs
    Inventors: David A. Haake, Bernard M. Churchill, Joseph C. Liao, Marc A. Suchard, Yang Li, Mitra Mastali
  • Publication number: 20080198881
    Abstract: Optical gain of a nonpolar or semipolar Group-III nitride diode laser is controlled by orienting an axis of light propagation in relation to an optical polarization direction or crystallographic orientation of the diode laser. The axis of light propagation is substantially perpendicular to the mirror facets of the diode laser, and the optical polarization direction is determined by the crystallographic orientation of the diode laser. To maximize optical gain, the axis of light propagation is oriented substantially perpendicular to the optical polarization direction or crystallographic orientation.
    Type: Application
    Filed: February 12, 2008
    Publication date: August 21, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Robert M. Farrell, Mathew C. Schmidt, Kwang Choong Kim, Hisashi Masui, Daniel F. Feezell, James S. Speck, Steven P. DenBaars, Shuji Nakamura
  • Publication number: 20080199462
    Abstract: Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic molecule, an antibody, or portion of an antibody that binds to and blocks the EGF receptor. The EGF-R antagonist is preferably administered by injection in an amount sufficient to inhibit formation of goblet cells in pulmonary airways. The degranulation of goblet cells that results in airway mucus production is thereby inhibited. Assays for screening candidate agents that inhibit goblet cell proliferation are also provided.
    Type: Application
    Filed: January 11, 2008
    Publication date: August 21, 2008
    Applicant: The Regents of the University of California
    Inventors: Jay A. Nadel, Kiyoshi Takeyama
  • Publication number: 20080197081
    Abstract: Compositions and methods and for contaminants from water are provided. The compositions comprise ferric hydroxide and ferric oxyhydride coated substrates for use in removing the contaminant from the water Contacting water bearing the contaminant with the substrates can substantially reduce contaminant levels therein. Methods of oxidizing the contaminants in water to facilitate their removal by the ferric hydroxide and ferric oxyhydride coated substrates are also provided. The contaminants include, but are not limited to, arsenic, selenium, uranium, lead, cadmium, nickel, copper, zinc, chromium and vanadium, their oxides and soluble salts thereof.
    Type: Application
    Filed: April 25, 2006
    Publication date: August 21, 2008
    Applicant: The Regents of the University of California
    Inventor: Ashok Jagannth Gadgil
  • Patent number: 7414124
    Abstract: This invention is directed to plant genetic engineering. In particular, it relates to, for example, modulating seed (and in particular endosperm, embryo and seed coat) development, flowering time, chromosomal DNA methylation and modulating transcription in plants.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: August 19, 2008
    Assignee: The Regents of the University of California
    Inventors: Robert L. Fischer, Yeonhee Choi, Mike Hannon
  • Patent number: 7414125
    Abstract: The present invention provides new miRNAs in rice. The nucleic acids of the invention can be used to control gene expression in plants.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: August 19, 2008
    Assignee: The Regents of the University of California
    Inventors: Jian-Kang Zhu, Ramanjulu Sunkar
  • Patent number: 7413873
    Abstract: The present invention is based, in part, on the discovery that colon carcinoma, carcinogenesis, or the predisposition thereto is associated with the level of Wnt2, Wnt5, BMP6, and Fz receptors and the full-length and dominant negative form of LEF1.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: August 19, 2008
    Assignee: The Regents of the University of California
    Inventors: Marian L. Waterman, Randall F. Holcombe, J. Lawrence Marsh, Karine Hovanes, Tony Wai Hung Li
  • Patent number: 7415299
    Abstract: A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: August 19, 2008
    Assignee: The Regents of the University of California
    Inventors: Stefan Zimmermann, Boris Stoeber, Dorian Liepmann, Albert Pisano
  • Patent number: 7414037
    Abstract: The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more hydrazide-containing compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a hydrazide-containing compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a hydrazide-containing compound.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: August 19, 2008
    Assignee: The Regents of the University of California
    Inventors: Alan Verkman, Nitin Dattatraya Sonawane, Chatchai Muanprasat
  • Patent number: 7414039
    Abstract: The present invention relates to a disorder of the lower urinary tract, and in particular, reducing the symptoms (including treatment) of interstitial cystitis in vivo. In a preferred embodiment, the present invention relates to treatment formulations and methods for reducing interstitial cystitis in patients.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: August 19, 2008
    Assignee: The Regents of the University of California
    Inventor: C. Lowell Parsons
  • Patent number: 7415285
    Abstract: The present invention provides a method for predicting channel power fading in a wireless communications system. This prediction method estimates the channel power fading via oversampling of the received and transmitted powers. The prediction method is then combined with several proposed structures for closed loop power control. The resulting structures result in improved performance in wireless communications systems.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: August 19, 2008
    Assignee: The Regents of the University of California
    Inventors: Mansour A. Aldajani, Ali H. Sayed
  • Patent number: 7413899
    Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: August 19, 2008
    Assignees: The Hospital for Sick Children, The Regents of the University of California
    Inventors: Joe W Gray, Colin Conrad Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
  • Publication number: 20080191598
    Abstract: Provided are electron emitters based upon diamondoid monolayers, preferably self-assembled higher diamondoid monolayers. High intensity electron emission has been demonstrated employing such diamondoid monolayers, particularly when the monolayers are comprised of higher diamondoids. The application of such diamondoid monolayers can alter the band structure of substrates, as well as emit monochromatic electrons, and the high intensity electron emissions can also greatly improve the efficiency of field-effect electron emitters as applied to industrial and commercial applications.
    Type: Application
    Filed: February 12, 2007
    Publication date: August 14, 2008
    Applicants: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of California
    Inventors: Wanli Yang, Jason D. Fabbri, Nicholas A. Melosh, Zahid Hussain, Zhi-Xun Shen