Abstract: Bulk acoustic wave resonators are presented. Such resonators typically operate based on a dynamic nonuniform effective piezoelectricity in composite multilayer ferroelectrics with large electrostriction coefficients, like barium strontium titanate (BST). Harmonic resonance modes of a multilayer bulk acoustic wave resonator can be selectively excited with an electromechanical coupling coefficient equal to the fundament mode, which is contrary to the trend K2?1/n2 exhibited by conventional piezoelectric bulk acoustic resonators. Such a resonator allows for the design of a new class of band-switching filters.

Abstract: A method of fabricating an organic optoelectronic device comprises positioning a patterning layer over a substrate, etching the patterning layer using a photolithographic process to create an etched patterning layer, positioning a layer of an organic material over the etched patterning layer, and removing at least a portion of the etched patterning layer and at least a portion of the layer of the organic material to create a patterned organic layer over the substrate.

Abstract: A sensor package and associated method provides roadside sensor-based data. The sensor package includes a controller, a network access device for remote communications, GNSS receiver, an inertial measurement unit (IMU), and environment sensors. The controller operates under software control and communicates with the other sensor package devices to: collect environment sensor data using the sensors; receive GNSS signals indicating current sensor package location; obtain IMU data; determine position/orientation data that includes position data and orientation data based on the orientation data is based on the IMU data; and send the environment sensor data and the position/orientation data of the sensor package to an external device using the network access device. The environment sensor data includes at least one sensor data frame, and the sensor data frame is matched with position/orientation data based on a time associated with collecting the sensor data frame and the position/orientation data.

Abstract: Methods and systems perform magnetic resonance fingerprinting (MRF) by obtaining magnetic resonance data over a main field-of-view (FOV) and resulting from providing a magnetic resonance fingerprinting pulse sequence to a sample. The pulse sequence includes gradient waveforms and radio frequency (RF) pulses that have pulse sequence parameters specifically tailored for scanning, not the entire main FOV but rather a reduced portion of that main FOV. The methods and systems further include comparing the magnetic resonance data from the sample to a fingerprint dictionary of signal profiles that specifically correspond to the reduced portion of the main FOV and generating tissue property maps that correspond only to that reduced portion.

Abstract: A method of and apparatus for sinter forging a precursor powder to form a film may reduce or eliminate the stress in the film and may facilitate processing of continuous length of films such as ceramic films for use in batteries. The precursor powder can be provided on a substrate and is simultaneously heated and pressed in a pressing direction parallel to a thickness of the film so as to sinter and densify the precursor powder to form the film in a sinter forging area. Notably, in a plane perpendicular to the pressing direction, there are no lateral constraints on the sinter forging area or the material received therein.

Abstract: A computer-implemented method includes receiving a raw data set representing an image of a sample, identifying a first set of extremum by analyzing the raw data set using a metric algorithm, identifying a second set of extremum by analyzing the first set of extremum, and generating, based on the second set of extremum, a reconstructed image of the sample. A phase correcting scanner includes one or more processors, one or more scanner adapted to sequentially sample an object to generate a vector of raw data representing the object in a Lissajous pattern, and memory storing instructions that, when executed by the one or more processors, cause the computing system to receive the vector of raw data, identify a first set of extremum by analyzing the raw data set using a metric algorithm, and identify a second set of extremum by analyzing the first set of extremum.

Abstract: Methods and systems perform magnetic resonance fingerprinting (MRF) that provides tissue characterization through simultaneous quantification of water tissue properties and proton density fat fraction (PDFF), by using water-only and fat-only images from MRF. MRF is performed using rosette trajectories scanning k-space to effectively isolate water tissue and fat tissue, by separating these rosette trajectories into individual segments that are then analyzed to enable signals from fat tissue to be distinguished from water.

Abstract: A method in a data processing system including at least one processor and at least one memory including instructions executed by the at least one processor to implement a lane change system is provided by the present disclosure. The method includes receiving, from at least one of a plurality of sensors coupled to a vehicle, information associated with a location of an object longitudinally ahead of the vehicle, determining a sequence of control inputs associated with a time horizon to avoid a collision between the vehicle and the object based on a constraint and the location of the object, and the determining the sequence of control inputs including minimizing a maximum tire slip angle of the vehicle during the time horizon subject to the constraint, and causing a vehicle control system of the vehicle to perform a vehicle maneuver based on the sequence of control inputs.

Abstract: Nearly all existing direct current (DC) chemical vapor sensing methodologies are based on charge transfer between sensor and adsorbed molecules. However, the high binding energy at the charge-trapped sites, which is critical for high sensitivity, significantly slows sensors' response and makes the detection of non-polar molecules difficult. By exploiting the incomplete screening effect of graphene, this disclosure demonstrates a DC graphene electronic sensor for rapid (sub-second) and sensitive (ppb) detection of a broad range of vapor analytes, including polar, non-polar, organic and inorganic molecules. Molecular adsorption induced capacitance change in the graphene transistor is revealed to be the main sensing mechanism. This work provides an avenue for a broad spectrum real-time gas sensing technology and serves as an ideal testbed for probing molecular physisorption on graphene.

Abstract: The invention disclosed herein generally relates to methods and systems for converting stem cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the invention disclosed herein relates to methods and systems for promoting vascularized human intestinal organoid tissue having an intestine-specific EC transcriptional signature from hindgut spheroid tissue produced in vitro from the described methods.

Abstract: The following relates generally to prediction of a patient's future work-status and their Return to Work (RTW) date(s). In some embodiments, a computer-implemented method includes: training a deep learning algorithm based on (i) input observations, and (ii) work-statuses; inputting, into the deep learning algorithm, observation data of the individual patient; and predicting, with the deep learning algorithm, a work-status of the individual patient based on the observation data of the individual patient.

Abstract: Provided are compositions, methods, and kits for CRISPR-based editing of DNA targets by Type I CRISPR-associated (Cas) enzymes.

Abstract: An acoustic lens to steer an acoustic beam includes a first structure, a second structure spaced from the first structure, an array of projections disposed between the first and second structures, each projection of the array of projections extending from the first structure toward the second structure to define a respective gap between the projection and the second structure, and an actuator configured to move the first structure, the second structure, or the array of projections for collective adjustment of the respective gaps of the array of projections. Each projection is configured to define one or more respective unit cells, each unit cell having a sub-wavelength size relative to the acoustic beam to establish an effective refractive index profile for the acoustic beam between the first and second structures.

Abstract: Disclosed are systems and methods to detect and identify vehicular anomalies. Techniques to detect and identify the vehicular anomalies include receiving signals from various sensors, grouping the signals into detection sets, detecting anomalies by a comparison to vehicle behavior models, and cross-referencing the detection sets with each other to narrow down and identify the source of the anomaly. The detection sets may be grouped such that facets of vehicle maneuverability are captured and cover causal relations between different maneuverability mechanisms.

Abstract: Image security is becoming an increasingly important issue with the progress of deep learning based image manipulations, such as deep image inpainting and deep fakes. There has been considerable work to date on detecting such image manipulations using better and better algorithms, with little attention being paid to the possible role hardware advances may have for more powerful algorithms. This disclosure proposes to use a focal stack camera as a novel secure imaging device for localizing inpainted regions in manipulated images. Applying convolutional neural network (CNN) methods to focal stack images achieves significantly better detection accuracy compared to single image based detection.

Abstract: The present invention relates to methods for synthesizing mixed disulfide conjugates of thienopyridine compounds with a genetically engineered variant of cytochrome P450 BM3 or CYP102A1 as a catalyst, and belongs to the field of chemical synthesis.

Abstract: Methods are disclosed herein for promoting survival of a donor liver in a recipient subject, wherein the donor liver is homozygous for rs738409:G mutation in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene. The method can include administering to the subject glutathione (GSH) and/or a nucleic acid molecule encoding a component of the ferroptosis pathway (such as GPX4).

Abstract: A phase locked loop (PLL) includes a phase detector configured to receive a reference signal and a feedback signal, wherein the reference signal has a reference frequency, sample the feedback signal, and output a phase detection signal indicative of a phase of the feedback signal. A voltage controlled oscillator is configured to generate an output signal based on the phase detection signal. The output signal has an output frequency greater than the reference frequency. Feedback circuitry is configured to detect a signal edge of the output signal and selectively supply, once per cycle of the reference signal, the detected signal edge of the output signal as the feedback signal.

Abstract: An engineered cementitious composite (ECC) that forms extremely durable concrete (EDC) is provide that includes Portland cement binder, a tire-derived rubber granular component (e.g., crumb rubber), a calcined clay component comprising a calcined clay, Portland cement component, and limestone, water, a superplasticizer, a polymeric or natural fiber, and optionally further including silica sand, microsilica, fly ash, a cellulose-based viscosity modifier, microsilica, or combinations thereof. Such an engineered cementitious composite has a tensile strain capacity of greater than or equal to about 3% and an ultimate tensile strength of greater than or equal to about 2.2 MPa. Such an ECC has high toughness and can be loaded in both tension and compression having a built-in capability of crack width control without the need for steel reinforcement.

Abstract: Methods for identifying patients diagnosed with treatment resistant or refractory depression, pain or other clinical indications who are eligible to receive N-methyl-D-aspartate receptor antagonist, glycine receptor beta (GLRB) modulator, or ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-based therapies to include determining the appropriate medication, an optimal dose for each patient, and determining which patients are not eligible to receive the therapy. The pharmacogenomic clinical decision support assays include targeted single nucleotide polymorphisms and clinical values or a combination of targeted single nucleotide polymorphisms, targeted ketamine-specific expansion and contraction of topologically associated domains, and clinical values. The methods described herein allow for a more effective determination of which patients will experience drug efficacy and which patients will experience adverse drug events.