Patents Assigned to Regents of the University of Michigan
  • Patent number: 12046788
    Abstract: Electromagnetic fields within a waveguide can be expressed in terms of the complex amplitudes of the electromagnetic modes it supports. The electromagnetic fields can be shaped by controlling the complex amplitudes of modes. Here, mode-converting metasurfaces are designed to transform a set of incident modes on one side to a different set of desired modes on the opposite side of the metasurface. A mode-converting metasurface comprises multiple inhomogeneous (spatially-varying) reactive electric sheets that are separated by dielectric spacers. The reactance profile of each electric sheet to perform the needed mode conversion is found through optimization. The optimization routine takes advantage of a multimodal solver that uses two main concepts: modal network theory and a discrete Fourier transform algorithm. With modal network theory, the modes can be translated between the electric sheets using matrix multiplication.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: July 23, 2024
    Assignee: The Regents of The University of Michigan
    Inventors: Faris Alsolamy, Anthony Grbic
  • Patent number: 12042554
    Abstract: The present disclosure relates to compositions capable of absorbing UVA and UVB light. In particle, the present disclosure relates to UV screening compositions comprising at least a portion of LITE-1 polypeptides which are capable of absorbing UV light (e.g., UV-A and/or UV-B light).
    Type: Grant
    Filed: February 16, 2023
    Date of Patent: July 23, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: X. Z. Shawn Xu, Jianfeng Liu
  • Patent number: 12044609
    Abstract: Investigating the permeability and porosity of geological samples is a routine element of geological studies, and is of particular interest in the oil and gas industry. Core-flood experiments are commonly performed on rock samples to measure transport characteristics in the laboratory. This disclosure reports the design and implementation of a high resolution distributed pressure measurement system for core-flood experiments. A series of microfabricated pressure sensors can be embedded in bolts that are housed within the pressurized polymer sheath that encases a rock core. A feedthrough technology has been developed to provide lead transfer between the sensors and system electronics across a 230-bar pressure difference. The system has been successfully benchtop tested with fluids such as synthetic oil and/or gas. Pressure measurements were recorded over a dynamic range of 20 bar with a resolution as small as 0.3 mbar.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: July 23, 2024
    Assignees: The Regents of The University of Michigan, TOTAL S.E.
    Inventors: Yogesh B. Gianchandani, Tao Li, Partha Dutta, Alexander Benken, John-Richard Ordonez-Varela
  • Patent number: 12036793
    Abstract: A method of fabricating a thin film structure includes printing, using an electrohydrodynamic jet (e-jet) printing apparatus, a first layer comprising a first liquid ink, such that the first layer is supported by a substrate, curing the first layer; printing, using the e-jet printing apparatus, a second layer comprising a second liquid ink, such that the second layer is supported by the first layer, and curing the second layer.
    Type: Grant
    Filed: June 14, 2023
    Date of Patent: July 16, 2024
    Assignee: The Regents of the University of Michigan
    Inventors: Brian Iezzi, Max Shtein, Zahra Afkhami Kheirabadi, Kira Barton
  • Patent number: 12038408
    Abstract: An integrated microfluidic photoionization detector (PID) is provided including a microfluidic ionization chamber a microfluidic ultraviolet radiation chamber that is configured to generate ultraviolet photons. An ultrathin transmissive window is disposed between the microfluidic ionization chamber and the microfluidic ultraviolet radiation chamber that permits the ultraviolet photons to pass from the microfluidic ultraviolet radiation chamber into the microfluidic ionization chamber. Detection systems for one or more VOC analytes are also provided that include a gas chromatography (GC) unit including at least one gas chromatography column and an integrated microfluidic photoionization detector (PID) disposed downstream of the gas chromatography (GC) unit.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: July 16, 2024
    Assignee: The Regents of The University of Michigan
    Inventors: Xudong Fan, Hongbo Zhu, Katsuo Kurabayashi
  • Patent number: 12038384
    Abstract: Various non-limiting examples of improved methods, devices, and systems for colorimetric detection of ambient aerosols are disclosed herein. For example, in certain embodiments, the methods, devices, and systems include direct measurement of size-resolved aerosol acidity from pH 0-4.5 using quantitative colorimetric image processing of mobile devices (e.g., a cellular phone) of aqueous aerosol particles impacted onto pH-indicator paper. One method includes collecting the ambient aerosol on a colorimetric pH sensitive surface; capturing, using a camera, an image of the colorimetric paper within a predefined period of time following the collecting of the ambient aerosol; and determining, by a processor, the pH of the ambient aerosol through a visual analysis of the captured image.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: July 16, 2024
    Assignee: The Regents of the University of Michigan
    Inventor: Andrew Ault
  • Patent number: 12040477
    Abstract: A lithium-ion battery includes an electrode with a plurality of channels formed at least partially through its thickness. Each channel has a diameter in a range from 5 ?m to 100 ?m and/or is spaced apart from another channel by a distance in a range from 10 ?m to 200 ?m as measured between centerlines of the channels. The electrode may be an anode and includes carbonaceous material such as graphite and/or additional electrochemically active lithium host materials. The battery can be charged at a C-rate greater than 2 C.
    Type: Grant
    Filed: March 14, 2023
    Date of Patent: July 16, 2024
    Assignee: The Regents of the University of Michigan
    Inventors: Kuan-Hung Chen, Neil Dasgupta, Jeffrey Sakamoto, Min Ji Namkoong
  • Patent number: 12036000
    Abstract: A method of diagnosing intraocular tumors including illuminating a tissue sample using a pulsed light source resulting in output of heat and thermoelastic expansion of the tissue sample. The thermoelastic expansion of the tissue sample produces propagating waves in ultrasonic frequencies. The propagating waves are acquired using an ultrasound system and back-projection reconstruction, thereby mapping anatomies with optical contrast at ultrasonic resolution to image intraocular tumors.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: July 16, 2024
    Assignee: The Regents of The University of Michigan
    Inventors: Hakan Demirci, Guan Xu
  • Publication number: 20240229242
    Abstract: Methods of forming a structural color metal-dielectric-metal (MDM) component via a solution-based process are provided. First, a first metal layer is formed over a treated surface of a substrate by a first electroless deposition process. A surface of the treated substrate is contacted with a first plating bath that comprises a metal selected from the group consisting of: copper, aluminum, silver, alloys, and combinations thereof. A dielectric layer, for example, comprising silicon dioxide, is then deposited over the first metal layer by a sol-gel process. Next, the method comprises forming a second metal layer over the dielectric layer by a second electroless deposition process by contacting the dielectric layer with a second plating bath having a neutral pH and comprising a metal selected from the group consisting of: copper, aluminum, silver, alloys, and combinations thereof.
    Type: Application
    Filed: October 19, 2023
    Publication date: July 11, 2024
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, NINGBO INLIGHT TECHNOLOGY CO., LTD.
    Inventors: Lingjie Jay GUO, Weijie FENG, Chengang JI
  • Publication number: 20240225860
    Abstract: Methods are disclosed for stimulating asynchronous and stochastic neural activity in a subject in need thereof. In some embodiments, the methods are used to provide asynchronous and stochastic neural activity in a limb of a subject with an amputation of the limb, for example, in a method of controlling the prosthetic limb of the subject.
    Type: Application
    Filed: May 3, 2022
    Publication date: July 11, 2024
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, The Regents of the University of Michigan
    Inventors: Beatrice Barra, Lee Erik Bartholomew Fisher, Marco Capogrosso, Ehsan Mirzakhalili, Scott Lempka
  • Patent number: 12029755
    Abstract: Disclosed herein are methods of treating venous thrombosis and vascular inflammation through administration of carbon monoxide and/or a carbon monoxide releasing molecule. Also disclosed herein are devices capable of releasing carbon monoxide for the purpose of treating microvascular, arterial and venous thromboembolism and/or inflammation.
    Type: Grant
    Filed: November 24, 2021
    Date of Patent: July 9, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Yogendra Kanthi, David J. Pinsky
  • Patent number: 12032190
    Abstract: Material-Sensing Light Imaging, Detection, And Ranging (LIDAR) systems optionally include a laser configured to generate a light pulse, a beam steerer configured to produce a polarization-adjusted light pulse emitted towards an object, at least one polarizer configured to polarize reflected, scattered, or emitted light returned from the object, and a processor configured to detect at least one material of the object based on an intensity and polarization of the polarized reflected, scattered or emitted light from the object. The beam steerer may include a kirigami nanocomposite. Methods are also provided, including, for example, generating a light pulse, adjusting a polarization of the light pulse to produce a polarization-adjusted light pulse emitted towards an object, polarizing reflected, scattered, or emitted light returned from the object, and detecting at least one material of the object based on an intensity and polarization of the polarized reflected, scattered or emitted light from the object.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: July 9, 2024
    Assignee: The Regents of The University of Michigan
    Inventors: Nicholas A. Kotov, Sharon Glotzer, Brian Shahbazian, Ryan Branch, Lizhi Xu, Wonjin Choi, Minjeong Cha, Matthew Spellings
  • Patent number: 12029490
    Abstract: The present invention relates to systems for low-energy (e.g., 1.0 nJ-7.0 nJ) photoacoustic microscopy and methods for employing such systems. In certain embodiments, such systems employ a low-energy nanosecond pulsed laser beam (NPLB), at least two amplifiers, and a data acquisition system with at least three channels to generate at least three digital signals (e.g., which are averaged and normalized to the energy of the NPLB). In other embodiments, provided herein are systems for combined use of photoacoustic microscopy, dye-based microscopy (e.g., with fluorescein), and optical coherence tomography.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: July 9, 2024
    Assignee: The Regents of the University of Michigan
    Inventors: Wei Zhang, Xueding Wang, Yannis Paulus
  • Patent number: 12029759
    Abstract: Provided herein are compositions and methods for treating neurological disorders. In particular, provided herein are neutrophils that rescue damaged neurons, methods of making such neutrophils, and methods of promoting generation of such neutrophils in vivo.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: July 9, 2024
    Assignee: The Regents of the University of Michigan
    Inventors: Benjamin M. Segal, Andrew Sas, Kevin Carbajal
  • Patent number: 12029055
    Abstract: A hybrid emissive layer and OLED incorporating the same are provided. The hybrid emissive layer includes a first material having a triplet state energy level T1H and a singlet state energy level S1H, a second material having a triplet state energy level T1F and a singlet state energy level S1F; and a third material having a triplet state energy level T1P and a single state energy level S1P, where T1FT1H; S1FS1H; and T1P<T1H.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: July 2, 2024
    Assignees: The University of Southern California, The Regents of the University of Michigan
    Inventors: Mark E. Thompson, Abegail Tadle, Muazzam Idris, Karim El Roz, Daniel Sylvinson Muthiah Ravinson, Stephen R. Forrest, Chan Ho Soh
  • Patent number: 12023388
    Abstract: Components, for example, nanoparticles for detecting and/or treating one or more active carious lesions or microcavities in teeth of a subject are provided. The component or nanoparticle may comprise a biocompatible and biodegradable polymer (e.g., a starch) bearing at least one cationic region and/or having a net positive charge and thereby capable of associating with one or more active and/or early carious lesions on a tooth in an oral cavity of a subject. The components or nanoparticles are optionally water soluble or dispersible. The components or nanoparticle also comprises an imaging agent (e.g., a fluorophore or dye) bonded to the biocompatible and biodegradable polymer. The component or nanoparticle is thus capable of indicating the presence of one or more active carious lesions when the component or nanoparticle is associated therewith. Oral care compositions comprising such compounds/nanoparticles and methods of making and using the same are also provided.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: July 2, 2024
    Assignees: The Regents of The University of Michigan, POZNAN UNIVERSITY OF MEDICAL SCIENCES
    Inventors: Joerg Lahann, Sywe-Ren Chang, Brian Clarkson, Nathan A. Jones, Agata Czajka-Jakubowska
  • Patent number: 12025669
    Abstract: A device for monitoring spacecraft electric potential includes a first conductor configured to be in electrical communication with a conductive structure of a spacecraft, a second conductor capacitively coupled to the first conductor, a switch connected to the first conductor and the second conductor such that closure of the switch electrically ties the first conductor to the second conductor, and a monitoring circuit in electrical communication with the second conductor, the monitoring circuit being configured to detect an electric potential of the second conductor relative to the first conductor, the detected electric potential being indicative of a change in electric potential of the first conductor relative to the second conductor since an opening of the switch.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: July 2, 2024
    Assignee: The Regents of the University of Michigan
    Inventor: Grant Camden Miars
  • Patent number: 12027963
    Abstract: A power conversion device may perform model-referenced power processing for multiple heterogenous power nodes. The power conversion device includes interconnects that couple power nodes to power converters. The power converters may include a sparse set in which the number of power converters is dependent on the model of the power source heterogeneity. The sparse set performs power processing on the power from the power node to facilitate provision of a target power at a port of the power conversion device.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: July 2, 2024
    Assignee: The Regents of the University of Michigan
    Inventors: Al-Thaddeus Avestruz, Xiaofan Cui, Jason Siegel
  • Publication number: 20240207617
    Abstract: Among the various aspects of the present disclosure is the provision for systems and methods for individualized targeting of deep brain stimulation (DBS). In addition, methods for monitoring the treatment of a subject using a DBS system are described.
    Type: Application
    Filed: December 1, 2023
    Publication date: June 27, 2024
    Applicants: Washington University, The Regents of the University of Michigan, Emory University
    Inventors: Peter Brunner, Markus Adamek, Jon Willie, Eric Leuthardt, Enrico Opri, Svjetlana Miocinovic
  • Patent number: 12018297
    Abstract: Provided herein is technology relating to molecular biological manipulation of genes and genomes and particularly, but not exclusively, to CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) methods, compositions, systems, and kits for improved genetic editing.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: June 25, 2024
    Assignee: The Regents of The University of Michigan
    Inventors: Jie Xu, Jifeng Zhang, Yuqing Eugene Chen, Dongshan Yang