Abstract: A process is provided for expanding the population of endothelial cells obtained from peripheral blood which can be transformed with a vector comprising a DNA sequence encoding a preselected bioactive polypeptide. The resulting transgenic endothelial cells are useful to biocompatibilize implantable medical devices or can be used directly, as for gene therapy.
Type:
Grant
Filed:
May 24, 2001
Date of Patent:
February 8, 2005
Assignee:
Regents of the University of Minnesota Emory University
Inventors:
Robert P. Hebbel, Yi Lin, John S. Lollar
Abstract: A process is provided for expanding the population of endothelial cells obtained from peripheral blood which can be transformed with a vector comprising a DNA sequence encoding a preselected bioactive polypeptide. The resulting transgenic endothelial cells are useful to biocompatibilize implantable medical devices or can be used directly, as for gene therapy.
Type:
Application
Filed:
May 24, 2001
Publication date:
April 11, 2002
Applicant:
Regents of the University of Minnesota and Emory University
Inventors:
Robert P. Hebbel, Yi Lin, John S. Lollar