Patents Assigned to Regents of the University of Washington
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Publication number: 20160251702Abstract: There is disclosed a PCR-based test kit and PCR process for identification of multiple clonal sub-species lineages of infectious bacteria, such as uropathogenic E. coli causing cystitis, pyelonephritis and urosepsis, for the purposes of predicting antibiotic resistance of the bacteria. More specifically, there is further disclosed a SNP (single nucleotide polymorphism) identification process that simultaneously detect compilations of the presence of absence of predictive SNPs within mutated loci of infectious bacterial clonal subspecies variants, such as the fumC/fimH loci of the E. coli bacterium. This disclosure provides a PCR detection kit incorporating a SNP compilation that forms a BFC (Binary Footprint Code) that allows for rapid identification of multiple infectious bacterial clonotypes based on their SNP footprint. More specifically there is disclosed a clonotyping method for clonal typing E.Type: ApplicationFiled: February 26, 2016Publication date: September 1, 2016Applicants: IDGenomics, Inc., Regents of the University of WashingtonInventors: Sujay Chattopadhyay, Pavel Aprikian, Evgeni Sokurenko
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Patent number: 7842478Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.Type: GrantFiled: August 9, 2006Date of Patent: November 30, 2010Assignee: The Board of Regents of the University of WashingtonInventors: Joseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
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Patent number: 7618793Abstract: Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are provided.Type: GrantFiled: October 20, 2004Date of Patent: November 17, 2009Assignee: The Regents of the University of WashingtonInventors: Paul J. Muchowski, Flaviano Giorgini
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Patent number: 7588887Abstract: Methods for the determination of the rate of synthesis of biopolymer synthesis and degradation in cells, tissues, or cell-free systems using monomer which has been labeled with a stable isotope are provided. Further, the present invention provides methods for the determination or identification of an unknown biopolymer and for the identification of an unknown cell type, a physiological state of a cell or tissue. Also, the present invention provides a database of descriptors which can be used to define an organism, tissue type, cell type, and the like, and which database can be used in conjunction with other public and private databases to identify or characterize an organism, tissue type, cell type, state of differentiation, or physiologic state of an organism, or tissue or cell sample.Type: GrantFiled: November 25, 2003Date of Patent: September 15, 2009Assignee: The Regents of the University of WashingtonInventors: B. Robert Franza, Jr., Yvan P. Rochon
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Publication number: 20060275871Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.Type: ApplicationFiled: August 9, 2006Publication date: December 7, 2006Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGTONInventors: Joseph Beavo, J. Bentley, Harry Charbonneau, William Sonnenburg
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Patent number: 7122363Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.Type: GrantFiled: October 30, 2003Date of Patent: October 17, 2006Assignee: The Board of Regents of the University of WashingtonInventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
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Patent number: 6867020Abstract: The Apa I restriction fragment of the human erythropoietin gene, for producing high titers of biologically active hormone from stably transfected cell lines.Type: GrantFiled: October 10, 2001Date of Patent: March 15, 2005Assignee: The Board of Regents of the University of WashingtonInventor: Jerry S. Powell
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Patent number: 6737059Abstract: Disclosed are methods for the alleviation of symptoms associated with inflammatory disease states, and more particularly to the inhibition of inflammatory disease processes associated with the multiple sclerosis disease, by adminstering to a patient a phamaceutically effective amount of mAb 23F2G or an antibody that competes with mAb 23F2G for binding to LFA-1.Type: GrantFiled: November 3, 1994Date of Patent: May 18, 2004Assignees: Board of Regents of the University Washington, ICOS CorporationInventor: Lynn M. Rose
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Patent number: 6653076Abstract: Methods for the determination of the rate of synthesis of biopolymer synthesis and degradation in cells, tissues, or cell-free systems using monomer which as been labeled with a stable isotope are provided. Further, the present invention provides method for the determination or identification of an unknown biopolymer and for the identification of an unknown cell type, a physiological state of a cell or tissue. Also, the present invention provides a database of descriptors which can be used to define an organism, tissue type, cell type, and the like, and which database can be used in conjunction with other public and private databases to identify or characterize an organism, tissue type, cell type, state of differentiation, or physiologic state of an organism, or tissue or cell sample.Type: GrantFiled: February 28, 2001Date of Patent: November 25, 2003Assignee: The Regents of the University of WashingtonInventors: B. Robert Franza, Jr., Yvan P. Rochon
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Patent number: 6642040Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.Type: GrantFiled: June 18, 2001Date of Patent: November 4, 2003Assignee: The Board of Regents of the University of WashingtonInventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
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Publication number: 20030006770Abstract: An MRI apparatus and method useful for both industrial applications and medical applications is provided. The apparatus and procedures are capable of estimating the value of a continuous property, such as concentration, viscosity or the like by interpolating or extrapolating from a model derived from training sets of data representing measurements of samples with known properties. A number of techniques are provided for objectifying the analysis. Cluster analysis techniques can be used to supplement, assist or replace subjective judgments by trained operators. Calculations or judgments regarding similarity can be made with respect to stored libraries of signatures, particularly where the library of stored signatures is obtained objectively, e.g., using cluster analysis, standardization and calibration. The signatures can be expanded signatures which include non-MR as well as MR data.Type: ApplicationFiled: March 19, 2002Publication date: January 9, 2003Applicant: Board of Regents of the University of WashingtonInventor: Justin P. Smith
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Publication number: 20020151024Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.Type: ApplicationFiled: June 18, 2001Publication date: October 17, 2002Applicant: The Board of Regents of the University of WashingtonInventors: Joseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
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Patent number: 6432681Abstract: Compositions and methods for diagnosing, treating and preventing recurrent E.Type: GrantFiled: July 9, 1999Date of Patent: August 13, 2002Assignees: The Regents of the University of Washington, The Biomembrane InstituteInventors: Ann Stapleton, Edward Nudelman, Walter E. Stamm, Sen-Itiroh Hakomori
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Patent number: 6319707Abstract: Retroviral vectors for producing coordinately expressed polycistronic mRNA in transfected host cells. A representative retroviral construct capable of forming a proviral genome in a host cell contains a first nucleotide coding sequence, a second nucleotide coding sequence, and a third nucleotide sequence capable of hybridizing under stringent conditions to a 5′ nontranslated region (NTR) of a picornavirus RNA or its complementary RNA strand. The first, second, and third nucleotide sequences are operably linked such that transcription of the proviral genome gives rise to a messenger RNA molecule containing transcripts of the first, second, and third nucleotide sequences. The transcript of the third nucleotide sequence in the messenger RNA molecule contains a nucleic acid capable of forming a regulatory stem-loop nucleic acid structure followed by at least one operable AUG start codon.Type: GrantFiled: January 26, 1993Date of Patent: November 20, 2001Assignee: Fred Hutchinson Cancer Research Center Board Regents of the University of WashingtonInventors: Mohammed A. Adam, A. Dusty Miller, William Reginald Alfred Osborne
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Patent number: 6304870Abstract: A procedure is disclosed for automatically constructing wrappers for performing information-extraction from sites such as Internet resources that display relevant information, interspersed with extraneous text fragments, such as HTML formatting commands or advertisements. The procedure has three basic steps. First, a set of example pages are collected with a subroutine named GatherExamples. Gather Examples is provided with information describing how to pose example queries to the site whose wrapper is to be learned. Second, these example pages are labeled by a subroutine named LabelExamples—i.e., the information to be extracted from each example is identified for use in the third step. The LabelExamples subroutine uses a general framework for labeling pages using site-specific heuristics called recognizers, as well as allowing users to correct and modify the recognized instances. Finally, the labeled example pages are passed to a BuildWrapper subroutine, which constructs a wrapper.Type: GrantFiled: December 2, 1997Date of Patent: October 16, 2001Assignee: The Board of Regents of the University of Washington, Office of Technology TransferInventors: Nicholas Kushmerick, Daniel S. Weld, Robert B. Doorenbos
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Patent number: 6161031Abstract: There is disclosed an apparatus for real-time imaging of cortical intrinsic signals or imaging tumor tissue or the margins, dimensions and grade of tumor tissue, comprising, a means for obtaining analog video images and a means for processing the analog video signals into either an averaged control frame or a subsequent frame, a means for acquiring and analyzing a plurality of subsequent frames and averaged control frame to provide a difference image, wherein the difference image is processed to account for movement and noise and amplify the changes across a dynamic range of the apparatus, and a means for displaying the difference image alone or superimposed over an analog video image.Type: GrantFiled: October 14, 1997Date of Patent: December 12, 2000Assignee: Board of Regents of the University of WashingtonInventors: Daryl Hochman, Michael M. Haglund
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Patent number: 6130205Abstract: A method for determining susceptibility to E. coli urinary tract infection comprising assaying a sample of epithelial cells for the presence or absence of at least one of Le.sup.a, sialosyl galactosyl-globoside, disialosyl galactosyl-globoside and an extended globo structure carrying the same terminal epitopes as Le.sup.a, sialosyl galactosyl-globoside or disialosyl galactosyl-globoside or assaying a sample of vaginal secretions for the presence or absence of at least one of sialosyl galactosyl-globoside or disialosyl galactosyl-globoside, and detecting the presence or absence of the at least one of Le.sup.Type: GrantFiled: June 6, 1995Date of Patent: October 10, 2000Assignees: The Regents of the University of Washington, The Biomembrane InstituteInventors: Ann Stapleton, Edward Nudelman, Sen-itiroh Hakomori, Walter E. Stamm, Mark Stroud
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Patent number: RE38981Abstract: Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors incorporating these sequences are also disclosed.Type: GrantFiled: August 13, 2002Date of Patent: February 14, 2006Assignee: Board of Regents of the University of WashingtonInventors: Donald C. Foster, Earl W. Davie
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Patent number: RE37958Abstract: Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors incorporating these sequences are also disclosed.Type: GrantFiled: June 15, 2001Date of Patent: January 7, 2003Assignee: Board of Regents of the University of WashingtonInventors: Donald C. Foster, Earl W. Davie
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Patent number: RE40811Abstract: The invention relates to in vivo peripheralization of CD34+ cells by administering anti-VLA-4 antibodies or anti-VCAM-1 antibodies.Type: GrantFiled: November 15, 1993Date of Patent: June 30, 2009Assignee: Board of Regents of the University of WashingtonInventor: Thalia Papayannopoulou