Patents Assigned to Regents of the University
  • Method of treating microbial infections
    Patent number: 10085997
    Abstract: The disclosure provides for novel antimicrobial agents, methods of making, and methods of use thereof.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Richard L. Gallo, Teruaki Nakatsuji
  • Methods for genome assembly and haplotype phasing
    Patent number: 10089437
    Abstract: The disclosure provides methods to assemble genomes of eukaryotic or prokaryotic organisms. The disclosure further provides methods for haplotype phasing and meta-genomics assemblies.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Richard E. Green, Jr., Liana F. Lareau
  • Growth of single crystal III-V semiconductors on amorphous substrates
    Patent number: 10087547
    Abstract: This disclosure provides systems, methods, and apparatus related to the growth of single crystal III-V semiconductors on amorphous substrates. In one aspect, a shape of a semiconductor structure to be formed on an amorphous substrate is defined in a resist disposed on the amorphous substrate. A boron group element is deposited over the amorphous substrate. A ceramic material is deposited on the boron group element. The resist is removed from the amorphous substrate. The ceramic material is deposited to cover the boron group element. The amorphous substrate and materials deposited thereon are heated in the presence of a gas including a nitrogen group element to grow a single crystal semiconductor structure comprising the boron group element and the nitrogen group element.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Kevin Chen, Rehan Kapadia, Ali Javey
  • Non-volatile solid state resistive switching devices
    Patent number: 10090463
    Abstract: Non-crystalline silicon non-volatile resistive switching devices include a metal electrode, a non-crystalline silicon layer and a planar doped silicon electrode. An electrical signal applied to the metal electrode drives metal ions from the metal electrode into the non-crystalline silicon layer to form a conducting filament from the metal electrode to the planar doped silicon electrode to alter a resistance of the non-crystalline silicon layer. Another electrical signal applied to the metal electrode removes at least some of the metal ions forming the conducting filament from the non-crystalline silicon layer to further alter the resistance of the non-crystalline silicon layer.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of Michigan
    Inventors: Wei Lu, Sung Hyun Jo
  • Syndecan-4 proteoliposomes for enhanced cutaneous wound healing and minimized inflammatory immune response
    Patent number: 10086041
    Abstract: Disclosed herein are compositions and articles for wound healing that contain proteovesicles, comprising a syndecan polypeptide embedded in a lipid vesicle, and a PDGF polypeptide. Also disclosed is the use of these compositions to enhance wound healing.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: October 2, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Aaron B. Baker, Subhamoy Das
  • Microfluidic assay devices and methods for making and using the same
    Patent number: 10088475
    Abstract: Microfluidic devices for determining whether an analyte is present in a sample are provided. The microfluidic devices include a polymeric medium that includes a first analyte detection domain having a first covalently bound capture member that specifically binds to a first analyte, and a second analyte detection domain having a second covalently bound capture member that specifically binds to a second analyte. Also provided are methods of using the subject microfluidic device, systems and kits that use the subject microfluidic devices, as well as methods of producing the same.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Amy E. Herr, Robert Lin
  • Biomolecular detection test strip design
    Patent number: 10088477
    Abstract: Described here are a device and a method for detecting the presence of a biomarker using the device, wherein the device comprises (a) a substrate comprising a plurality of electrodes; (b) a plurality of nanowire field-effect transistor sensors integrated or assembled on the substrate and connected to the electrodes; and (c) a microfluidic component disposed on the substrate and adapted to communicate fluidically with the nwFET sensors.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of California
    Inventor: Chi On Chui
  • Method for distance-vector routing using adaptive publish-subscribe mechanisms
    Patent number: 10091094
    Abstract: A distance-vector based routing protocol that integrates with adaptive publish-subscribe mechanisms by establishing routes to well-known controllers using distance-vector signaling.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Jose Garcia-Luna-Aceves, Qian Li
  • Apparatus and methods for bidirectional hyperelastic stent covers
    Patent number: 10085862
    Abstract: An apparatus and method for a micro-patterned thin film Nitinol (TFN) that is used as a cover for an expandable stent structure, and has elongation/expansion properties that are configured to match the elongation/expansion properties of the expandable stent structure is presented.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: October 2, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Greg Carman, Daniel S. Levi, Mohanchandra Kotekar Panduranga, Fernando Vinuela, Abdon E. Sepulveda
  • System and method to define drivers of sources associated with biological rhythm disorders
    Patent number: 10085655
    Abstract: A system and method are provided for identifying a driver of a source associated with a heart rhythm disorder. Data are accessed from a plurality of sensors representing biological activity in the heart. A local first region of the heart that has repeating activation and determine whether the first region controls a second distant region of the heart for at least a predetermined number of beats is identified. The first local region is assigned as a driver of a source of the heart rhythm disorder, the source including the first local region and the second distant region.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 2, 2018
    Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans Affairs, Topera, Inc.
    Inventors: Sanjiv Narayan, Carey Robert Briggs, Ruchir Sehra
  • Magnetoelectric memory cells with domain-wall-mediated switching
    Patent number: 10090034
    Abstract: A magnetoelectric memory cell with domain-wall-mediated switching is implemented using a split gate architecture. The split gate architecture allows a domain wall to be trapped within a magnetoelectric antiferromagnetic (MEAF) active layer. An extension of this architecture applies to multiple-gate linear arrays that can offer advantages in memory density, programmability, and logic functionality. Applying a small anisotropic in-plane shear strain to the MEAF can block domain wall precession to improve reliability and speed of switching.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: October 2, 2018
    Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, THE JOHN HOPKINS UNIVERSITY, INTEL CORPORATION
    Inventors: Kirill D. Belashchenko, Oleg Tchernyshyov, Alexey Kovalev, Dmitri E. Nikonov
  • Methods and compositions for treating and preventing disease associated with ?v?5 integrin
    Patent number: 10087252
    Abstract: The present invention provides compositions and methods for treating and preventing disease associated with ?v?5 integrin by blocking binding to ?v?5 integrin. In particular, antibodies specific for ?v?5 integrin are useful for preventing, treating, and reversing sepsis.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: October 2, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dean Sheppard, George Su, Amha Atakilit
  • Methods of making and using live attenuated viruses
    Patent number: 10086063
    Abstract: This disclosure provides a platform for making live, attenuated viruses. This disclosure also provides methods of using the live, attenuated viruses.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 2, 2018
    Assignee: Regents of the University of Minnesota
    Inventors: Ryan Andrew Langlois, Jessica Karen Fiege, Louisa Elizabeth Sjaastad, Barbara Mae Waring
  • Solid-state multi-layer electrolyte, electrochemical cell and battery including the electrolyte, and method of forming same
    Patent number: 10090557
    Abstract: An electrochemical cell including a multi-layer solid-state electrolyte, a battery including the cell, and a method of forming the battery and cell are disclosed. The electrolyte includes a first layer that is compatible with the anode of the cell and a second layer that is compatible with the cathode of the cell. The cell exhibits improved performance compared to cells including a single-layer electrolyte.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: James Trevey, Se-hee Lee, Jae-Ha Woo
  • MicroRNA composition for the treatment of neuroblastoma
    Patent number: 10087444
    Abstract: Certain embodiments are directed to methods of identifying neuroblastoma differentiation-inducing compounds or agent and their use in treating neuroblastoma.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: October 2, 2018
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Luqin Du
  • Metal organic frameworks comprising a plurality of SBUS with different metal ions and/or a plurality of organic linking ligands with different functional groups
    Patent number: 10087205
    Abstract: The disclosure provides for metal organic frameworks (MOFs) which comprise a plurality of SBUs comprising different metals or metal ions and/or a plurality of organic linking moieties comprising different functional groups.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Omar M. Yaghi, Mitsuharu Suzuki, Hexiang Deng, Lisa Wang
  • Method of preparation of biodegradable nanoparticles with recognition characteristics
    Patent number: 10086091
    Abstract: The present disclosure relates to a novel type of recognitive biodegradable nanoparticles and their preparations. In particular, the present disclosure relates to combinations of MIPs and biodegradable nanoparticles.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: October 2, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nicholas Peppas, Heidi Culver
  • Polypeptdes, cells, and methods for biofilm therapy and detection
    Patent number: 10087241
    Abstract: This disclosure describes a fusion polypeptide that includes an anchor domain and a binding domain that specifically binds to a target biofilm. The anchor domain generally includes at least a portion of a cell membrane polypeptide. The binding domain includes a sufficient portion of a polypeptide that specifically binds to a component of a target biofilm to specifically bind to the target biofilm. This disclosure also describes cells that include the fusion polypeptide and methods involving the use of such cells.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: October 2, 2018
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Christine Elizabeth Salomon, Joshua D. Erickson
  • Minimally invasive glaucoma surgical instrument and method
    Patent number: 10085885
    Abstract: Apparatuses and methods for the treatment of glaucoma are provided. The instrument uses either cauterization, a laser to ablate, sonic or ultrasonic energy to emulsify, or mechanical cutting of a portion of the trabecular meshwork. The instrument may also be provided with irrigation, aspiration, and a footplate. The footplate is used to enter Schlemm's canal, serves as a guide, and also protects Schlemm's canal.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: October 2, 2018
    Assignee: The Regents of the University of California
    Inventors: George Baerveldt, Roy Chuck
  • INDUCED PLURIPOTENT STEM CELL DERIVED GLIAL ENRICHED PROGENITOR CELLS FOR THE TREATMENT OF WHITE MATTER STROKE
    Publication number: 20180271911
    Abstract: In various embodiments methods and compositions for improving a recovery of a subject after a cerebral ischemic injury, such as white matter stroke are provided. In certain embodiments, the methods involve administering human induced pluripotent glial enriched progenitor cells into the brain of the subject.
    Type: Application
    Filed: September 27, 2016
    Publication date: September 27, 2018
    Applicant: The Regents of the University of California
    Inventors: Stanley Thomas Carmichael, Irene Lorenzo Llorente, William E. Lowry