Patents Assigned to Regents of the University
  • Method for enhancing power amplifier efficiency and linearity and power amplifier
    Patent number: 12249963
    Abstract: A method for power amplification uses circuitry including a main amplifier and an auxiliary amplifier that are constructed and operate such that an input is applied to the main and auxiliary amplifiers via an input network. At low power levels, the auxiliary amplifier is off and the main amplifier sees a large impedance. At maximum power level, both the auxiliary and main amplifiers operate at full power and there is a constant phase shift between them. While transitioning from low to maximum power, systematic AM-AM and AM-PM variations generated due to the phase shift provided by the input network, bias differences between the main and auxiliary amplifiers, and nature of the output combiner to compensate device related distortions.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: March 11, 2025
    Assignee: The Regents of the University of California
    Inventors: Seyed Bagher Rabet, Peter M. Asbeck
  • Natural ear
    Patent number: 12249343
    Abstract: Methods and systems for assisting tonally-challenged singers. A microphone can be integrated with a sound reinforcement system used in a live performance. The microphone, which can transduce the performer's voice, can serve multiple purposes such as, for example, to feed input to the natural ear and to the sound reinforcement system. The processed sound of the performer's voice (with fundamental frequency emphasized) can be mixed into the signal fed to a stage “monitor” speaker facing the performer or a headset worn by the performer.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: March 11, 2025
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eric A. Freudenthal, Eric M. Hanson, Bryan E. Usevitch
  • Remote measurement of shallow depths in semi-transparent media
    Patent number: 12248105
    Abstract: Through discrimination of the scattered signal polarization state, a lidar system measures a distance through semi-transparent media by the reception of single or multiple scattered signals from a scattering medium. Combined and overlapped single or multiple scattered light signals from the medium can be separated by exploiting varying polarization characteristics. This removes the traditional laser and detector pulse width limitations that determine the system's operational bandwidth, translating relative depth measurements into the conditions of two surface timing measurements and achieving sub-pulse width resolution.
    Type: Grant
    Filed: April 10, 2023
    Date of Patent: March 11, 2025
    Assignees: The Regents of the University of Colorado, a body corporate, Lite Wave Technologies, Inc.
    Inventors: Jeffrey P. Thayer, Andrew W. Gisler, Steven Mitchell, Matthew Hayman
  • System and method for extended spectrum ultrasound training using animate and inanimate training objects
    Patent number: 12249250
    Abstract: A system and method for extended spectrum ultrasound training using tags placed on animate and/or inanimate objects. The system combines the use of tags, a reader, and a 3-DOF motion tracker to train a user in finding image windows and optimal image views in an ultrasound simulation environment.
    Type: Grant
    Filed: February 27, 2023
    Date of Patent: March 11, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Eric Savitsky, Gabriele Nataneli, Dan Katz
  • Polymer electrolyte membranes
    Patent number: 12249688
    Abstract: Polymer electrolyte membranes (PEMs) that include co-continuous domains of a conductive phase and a crosslinked network phase. The conductive phase can include one or more polymers having glass transition temperatures below room temperature. The crosslinked network phase can be formed from at least one monofunctional monomer and at least one di- or greater functional monomer.
    Type: Grant
    Filed: December 28, 2021
    Date of Patent: March 11, 2025
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Marc A. Hillmyer, Timothy Patrick Lodge, Lucas David McIntosh, Morgan Whitney Schulze
  • Medical devices including textured inflatable balloons
    Patent number: 12245743
    Abstract: A medical device includes an elongate body and an inflatable balloon attached to and partially surrounding at least a section of the elongate body. The inflatable balloon is selectively inflatable between a deflated state and an inflated state. Engagement between the balloon and a physiological lumen is provided, in part, by multiple protrusions extending from the inflatable balloon and having various physical and functional characteristics. In certain implementations, the balloon may be configured to exhibit various separation forces by applying different strains to the balloon, such as by varying the degree to which the balloon is inflated or deflated.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: March 11, 2025
    Assignee: The Regents of the University of Colorado
    Inventors: Mark E. Rentschler, Steven A. Edmundowicz, Karl Johannes
  • METHODS FOR PRODUCTION OF THERAPEUTIC IMMUNE CELLS HAVING ENHANCED METABOLIC FITNESS AND COMPOSITIONS THEREOF
    Publication number: 20250074950
    Abstract: Aspects of the present disclosure include methods and compositions related to therapeutic immune cells having enhanced metabolic fitness. In certain aspects, polynucleotides encoding one or more viral, bacterial, and/or fungal genes capable of manipulating cell metabolism and, optionally, one or more antigen-specific receptors, are disclosed. In some aspects, disclosed are methods for enhancing the metabolic fitness of an immune cell comprising introducing into the immune cell a polynucleotide encoding one or more viral, bacterial, and/or fungal genes capable of manipulating cell metabolism. Cells (e.g., NK cells, T cells) expressing polynucleotides encoding one or more viral, bacterial, and/or fungal genes capable of manipulating cell metabolism and, optionally, one or more antigen-specific receptors are described. Also described are therapeutic methods using polynucleotides of the disclosure.
    Type: Application
    Filed: October 21, 2022
    Publication date: March 6, 2025
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: May DAHER, Rafet BASAR, Sunil ACHARYA, Katy REZVANI, Ana Karen NUNEZ CORTES, Nadima UPRETY, Emily ENSLEY
  • PEPTIDES AND ENGINEERED T CELL RECEPTORS TARGETING FANCI, RAD51, AND PBK ANTIGENS AND METHODS OF USE
    Publication number: 20250073333
    Abstract: This disclosure provides for engineered T cell Receptors (TCRs), cells comprising the TCRs, and methods of making and using the TCRs. The current disclosure relates to TCRs that specifically recognize epitope(s) from tumor antigens FANCI, RAD51, and PBK. Accordingly, aspects of the disclosure relate to an engineered T-cell Receptors (TCRs), nucleic acids encoding the TCRs, and cells comprising the nucleic acids and TCRs. Also provided are compositions comprising the cells, nucleic acids, or engineered TCRs of the disclosure, methods of making the cells and methods of using the embodiments of the disclosure for therapeutic treatments.
    Type: Application
    Filed: July 18, 2022
    Publication date: March 6, 2025
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Cassian YEE, Ke PAN, Yulun CHIU
  • BI-SPECIFIC ANTIBODIES AND USE THEREOF
    Publication number: 20250074992
    Abstract: Provided herein are bispecific antibodies binding to VEGF and EGFR or VEGF and HER2, and their use in treating cancer.
    Type: Application
    Filed: November 18, 2024
    Publication date: March 6, 2025
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zhen FAN, Yang LU, Songho QIU
  • Hardware Interaction Proxy For Accessing Touchscreens
    Publication number: 20250077068
    Abstract: Touchscreen devices, designed with an assumed range of user abilities and interaction patterns, often present challenges for individuals with diverse abilities to operate independently. Prior efforts to improve accessibility through tools or algorithms necessitated alterations to touchscreen hardware or software, making them inapplicable for the large number of existing legacy devices. This disclosure introduces a hardware interaction proxy that performs physical interactions on behalf of users while allowing them to continue utilizing accessible interfaces, such as screen readers and assistive touch on smartphones, for interface exploration and command input. The proxy maintains an interface model for accurate target localization and utilizes exchangeable actuators for physical actuation across a variety of device types, effectively reducing user workload and minimizing the risk of mistouch.
    Type: Application
    Filed: August 27, 2024
    Publication date: March 6, 2025
    Applicant: The Regents of The University of Michigan
    Inventors: Anhong GUO, Alanson SAMPLE, Ruijie GENG, Thomas KROLIKOWSKI, Yasha IRAVANTCHI, Chen LIANG
  • HYPERSPECTRAL COMPRESSIVE IMAGING WITH INTEGRATED PHOTONICS
    Publication number: 20250076573
    Abstract: One embodiment provides a compressive hyperspectral imaging system. The compressive hyperspectral imaging system can include a coded aperture configured to spatially encode an optical signal associated with a scene, an integrated photonic device configured to disperse the spatially encoded optical signal, and an array of photo detectors configured to detect the dispersed and spatially encoded optical signal. The output of the array of photo detectors is used for reconstruction of a hyperspectral image corresponding to the scene.
    Type: Application
    Filed: April 19, 2022
    Publication date: March 6, 2025
    Applicant: The Regents of the University of California
    Inventor: Sung-Joo Ben Yoo
  • Method for Measuring Periodic Headpulse Sleep Bursts to Determine Brain Health
    Publication number: 20250072818
    Abstract: In a normal human being the pulsing of blood through the brain during sleep causes a periodic headpulse of high amplitude, detectable and measurable using cranial accelerometry. A patient's sleeping headpulse is compared to one or more reference headpulse patterns from normal and abnormal patients to determine health and condition of the brain and vasculature.
    Type: Application
    Filed: August 30, 2024
    Publication date: March 6, 2025
    Applicant: The Regents of the University of California
    Inventors: Paul A. Lovoi, Wade Smith
  • PEPTIDES, HYDROGEL COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20250074956
    Abstract: The invention provides antibiotic BPI Fold Containing Family A Member 2 (BPIFA2) peptides, compositions comprising a BPIFA2 peptide, hydrogels comprising a BPIFA2 peptide, nanofibrillar networks comprising a BPIFA2 peptide, and tissue scaffolds comprising BPIFA2 peptides. The peptide, compositions, hydrogels nanofibrillar networks and tissue scaffolds are useful for medical therapy in an animal.
    Type: Application
    Filed: June 5, 2024
    Publication date: March 6, 2025
    Applicant: Regents of the University of Minnesota
    Inventors: Sven-Ulrik Gorr, Conrado Aparicio, Zhou Ye
  • TRUNK SUPPORT EXOSKELETON WITH ONE POWERED ACTUATOR
    Publication number: 20250073891
    Abstract: A trunk-supporting exoskeleton for reducing muscle forces in a wearer's back during forward lumbar flexion comprises a supporting trunk, a first thigh link, a second thigh link, and an actuator, which includes an actuator first element and an actuator second element. When the wearer is in a forward-bent position, the actuator generates a first torque on the actuator first element and a second actuator torque on the actuator second element to generate extension torques between the first and second thigh links and the supporting trunk, thereby resisting bending motion of the supporting trunk in the forward-bent position. When the wearer is not in the forward-bent position, the actuator generates a substantially small first torque and second torque, resulting in small resistance to the movement of the thigh links relative to the supporting trunk during walking.
    Type: Application
    Filed: October 11, 2024
    Publication date: March 6, 2025
    Applicants: The Regents of the University of California, suitX, Inc.
    Inventors: Wayne TUNG, Homayoon KAZEROONI, Jing-Song HUANG, Yi ZENG, Zhendong LIU
  • GENE/PROTEIN EXPRESSION GUIDED MELANOMA SURGERY
    Publication number: 20250075275
    Abstract: Provided herein are methods for locating and characterizing a melanoma tumor by detecting expression levels of one or both of S100A8 and S100A9. The provided methods are particularly useful for evaluating spatially specific properties of the tumor, and for using this information to locate the border of the tumor, surgically removing the tumor, or treat the tumor by administering a particularly determined dosage of a therapeutic agent.
    Type: Application
    Filed: August 5, 2022
    Publication date: March 6, 2025
    Applicant: The Regents of the University of California
    Inventors: John McPherson, Maija Kiuru
  • ZERO LIQUID DISCHARGE EUTECTIC FREEZE DESALINATION WITH INTERMEDIATE COLD LIQUID
    Publication number: 20250074790
    Abstract: A method for desalinating a brine includes the use of a cooled intermediate-cold-liquid (ICL), which combines with the brine in a crystallization or freezing tank, where the brine and cooled ICL are contacted for a time sufficient to produce a slurry of ice, brine, and ICL. The method includes steps for separating the ICL, ice and brine, and melting the separated ice to form a volume of desalinated water. The method is significant in that it produces desalinated liquid water and solid salts. The combination of superior heat transfer with high quality purified water and competitive desalination economy makes the disclosed freeze desalination technology an attractive solution for desalination of highly concentrated brines produced in a variety of industries, including but not limited to the oil and gas industry and reject brine management.
    Type: Application
    Filed: November 14, 2024
    Publication date: March 6, 2025
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Hamidreza Shabgard, Ramkumar N. Parthasarathy, Jie Cai
  • Expert-level detection of acute intracranial hemorrhage on head CT scans
    Patent number: 12243297
    Abstract: A computer-implemented method can include a training phase and a hemorrhage detection phase. The training phase can include: receiving a first plurality of frames from at least one original computed tomography (CT) scan of a target subject, wherein each frame may or may not include a visual indication of a hemorrhage, and further wherein each frame including a visual indication of a hemorrhage has at least one label associated therewith; and using a fully convolutional neural network (FCN) to train a model by determining, for each of the first plurality of frames, whether at least one sub-portion of the frame includes a visual indication of a hemorrhage and classifying the sub-portion of the frame based on the determining.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: March 4, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jitendra Malik, Pratik Mukherjee, Esther L. Yuh, Wei-Cheng Kuo, Christian Haene
  • Electrochemical sensing of PFAS using gold nanoparticle functionalized electrodes
    Patent number: 12241855
    Abstract: A method of electrochemical sensing includes providing an electrochemical sensor comprising a glassy carbon substrate and gold nanoparticles located on a surface of the glassy carbon substrate; and sensing electrochemically a compound selected from the group consisting of polyfluoroalkyl compounds or perfluoroalkyl compounds using the electrochemical sensor. PFOA quantification was performed by Square Wave Adsorptive Cathodic Stripping Voltammetry (SW-AdCSV) in test solutions with a 100-5,000 ppt concentration. The concentration has a linear relationship with the stripping current within this range. Analysis of tap and groundwater samples performed by additions method demonstrated precision and accuracy above 95%. These electrodes show stability throughout 200 cycles, and reproducibility across similarly prepared but different electrodes above 97.5%.
    Type: Grant
    Filed: June 15, 2023
    Date of Patent: March 4, 2025
    Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on Behalf of Arizon State University
    Inventors: Dino Villagran, Paul Westerhoff, Jonathan Josue Calvillo Solis, Michael Wong
  • Peptide therapeutics for treating Alzheimer's disease and related conditions
    Patent number: 12241099
    Abstract: Peptide compounds derived from cathepsin G (CG), neutrophil elastase (NE), and cationic antimicrobial protein of 37 kDa (CAP37), and methods of their use in inhibiting and/or reversing polymerization of amyloid ? peptide into oligomers and/or fibrils, and/or disaggregating amyloid ? plaques, and methods of use of the peptide compounds in treatments of, for example, Alzheimer's disease, cerebral amyloid angiopathy, dementia, and/or neuroinflammation, and/or symptoms thereof are disclosed.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: March 4, 2025
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Anne Kasus-Jacobi, Heloise Anne Pereira, Amanda J. Stock
  • Solid-state positive electrode, method of manufacture thereof, and battery including the electrode
    Patent number: 12244002
    Abstract: A positive electrode for a solid-state lithium battery, the positive electrode including: a positive active material; and a first solid electrolyte, wherein a ratio ? of an average particle diameter of the positive active material to an average particle diameter of the first solid electrolyte is 3???40, wherein the positive active material has an average particle diameter of 1 ?m to 30 ?m, and wherein the first solid electrolyte has an average particle diameter of 0.1 ?m to 4 ?m.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: March 4, 2025
    Assignees: SAMSUNG ELECTRONICS CO., LTD., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Qingsong Tu, Tan Shi, Gerbrand Ceder, Lincoln Miara