Abstract: A system for assaying forces applied by cells includes an optically transparent substrate comprising a soft material having a Young's modulus within the range of about 3 kPa to about 100 kPa. An array of molecular patterns is disposed on a surface of the optically transparent substrate, the molecular patterns include fluorophore-conjugated patterns adherent to cells. The system includes at least one light source configured to excite the fluorophore-conjugated patterns and an imaging device configured to capture fluorescent light emitted from the fluorophore-conjugated patterns. Dimensional changes in the size of the patterns are used to determine contractile forces imparted by cells located on the patterns.

Abstract: A device and method for converting magnetic flux to voltage uses a linear Fraunhofer pattern of a 1D array of long Josephson junctions. The 1D array of Josephson junctions may include from 1 to 109 junctions formed in a planar geometry with a bridge width within the range of 4-10 ?m.

Abstract: Embodiments of the present systems and methods may provide imaging techniques for multidirectional imaging, light conditioning, illumination sequences, or machine learning to create algorithms created from training by other advanced imaging techniques. In an embodiment, a method for generating an image may comprise obtaining an image of an object produced by a camera and generating, from the obtained image produced by a conventional camera, using an artificial intelligence model and imaging process, an output image including additional information similar to additional information present in an image of the object produced by an advanced imaging system.

Abstract: A Modular Multilevel Converter (MMC) circuit for converting DC power to AC and vice versa. At each respective connection to the AC power-source/load, the MMC circuit uses one Pulse Width Modulation Insulated Gate Bipolar Transistor (PWM IGBT) to control the switching between upper and lower arms of sub-modules. The circuit eliminates the inter-phase inductors often used in MMCs, and replaces the inductors by two complementary-gated PWM IGBTs, thereby eliminating circulating current. Moreover, the multilevel converter topology disclosed herein requires less number of components including PWM IGBTs and capacitors. In fact, at least two submodules per-phase are eliminated: one submodule in the upper arm and one submodule in the lower arm. In other words, the MMC topology not only mitigates the circulating current but also eliminates at least one submodule in the upper arm and at least one submodule in the lower arm per-phase.

Abstract: An improved system and methods for enhancing the imaging of cameras included with wireless mobile devices, such as cellular phone or tablets. The imaging system includes a releasable optical attachment for imaging skin surfaces and cavities of the body. The releasable optical attachment comprises optical enhancement elements such as magnifying lenses, illumination diverting elements, and filters. Images can be viewed and analyzed on the mobile device, or transmitted to another location/device for analysis by a person or software. The results can be used to provide diagnosis, or for a variety of other applications including image comparison over time and product recommendations.

Abstract: A method for fabricating a composite film structure, the method includes determining a desired morphology for a metallic layer of the composite film structure, selecting a first metal substrate based on the determining, transferring a graphene layer onto the first metal substrate, depositing the metallic layer on the graphene layer to achieve the desired morphology, and removing the first metal substrate from the graphene and the deposited metallic layer to form the composite film structure. A surface energy difference between the first metal substrate and the deposited metallic layer results in the desired morphology of the metallic layer.

Abstract: Imaging based detection of changes in extracellular neurotransmitter concentration in living tissue is achieved using novel nanotube-based sensors. The sensors are functionalized, neurocompatible single-walled carbon nanotubes (SWNT) comprising an adsorbed neurotransmitter analyte selective polynucleotide.

Abstract: A III-nitride optoelectronic device includes at least one n-type layer, an active region grown on or above the n-type layer, at least one p-type layer grown on or above the active region, and a tunnel junction grown on or above the p-type layer. A conductive oxide may be wafer bonded on or above the tunnel junction, wherein the conductive oxide comprises a transparent conductor and may contain light extraction features on its non-bonded face. The tunnel junction also enables monolithic incorporation of electrically-injected and optically-pumped III-nitride layers, wherein the optically-pumped III-nitride layers comprise high-indium-content III-nitride layers formed as quantum wells (QWs) that are grown on or above the tunnel junction. The optically-pumped high-indium-content III-nitride layers emit light at a longer wavelength than the electrically-injected III-nitride layers.

Abstract: Reflectin proteins are proteins derived from cephalopods (certain species of squid) which have unusual optical properties. Disclosed herein are thin films of reflectin proteins which can be tuned to reflect infrared light. Advantageously, the films can be tuned dynamically over short time scales, to reflect at different wavelengths. Disclosed herein are novel infrared-reflective coatings, methods of making such coatings, and infrared-reflective objects such as textiles, building materials, and camouflage materials.

Abstract: Systems and methods of determining physical conditions of a battery, such as state of charge (SOC), state of health (SOH), quality of construction, defect, or failure state include driving two or more acoustic signals of two or more amplitudes, each acoustic signal having two or more frequencies, into the battery and detecting vibrations generated in the battery based on the two or more acoustic signals. Nonlinear response characteristics of the battery for the two or more acoustic signals are determined from the detected vibrations. The physical conditions of the battery are determined based at least in part on the nonlinear response characteristics, using nonlinear acoustic resonance spectroscopy (NARS) or nonlinear resonant ultrasound spectroscopy (NRUS).

Abstract: This disclosure provides non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries. In certain embodiments the method involves administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces the desired locomotor activity.

Abstract: Methods for predicting patient deterioration or clinical events by detecting patterns in heterogeneous temporal clinical data streams that are predictive of certain clinical end points and matching the patient state with those patterns are described. The detected patterns, referred to as SuperAlarm triggers, are a predictive combination of frequently co-occurring monitor alarms, conditions and laboratory test results that can predict patient deterioration for imminent life-threatening events. SuperAlarm triggers may also exhibit patterns in the sequence of SuperAlarms that are triggered over the monitoring time of a patient. Sequential patterns of SuperAlarm triggers may also indicate a temporal process of change in patient status. SuperAlarm based alerts will also greatly reduce the number of false alarms and alarm fatigue compared to conventional alarms.

Abstract: The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.

Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.

Abstract: Provided herein, inter alia, are methods and compounds for inhibiting mTORC1 and for treating diseases associated with mTORC1 activity.

Abstract: A heterodyne optical spectroscopy system comprises a light source that acts as a local oscillator (LO); a beam splitting component that generates a reference beam from the LO; a signal component that generates a sample signal from a sample; a beam blocker that can turn off the sample signal to generate blank shots; a composite signal detection subsystem that detects a heterodyned signal that is a mix of the sample signal and a portion of the LO; a composite reference detection subsystem synchronized to the signal detection subsystem to detect a portion of the reference beam; and a processor that processes digital signals from the signal detection subsystem and the reference detection subsystem. A very versatile reference scheme is developed to treat different heterodyne spectroscopies in a unified way, which achieves optimal noise suppression.

Abstract: A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure.

Abstract: A security primitive for an integrated circuit comprises an array of floating-gate transistors monolithically integrated into the integrated circuit and coupled to one another in a crossbar configuration. The floating-gate transistors have instance-specific process-induced variations in analog behavior to provide one or more reconfigurable physically unclonable functions (PUFs).

Abstract: In one aspect, there is provided a display. The display may include a waveguide layer, a first active layer, a redirecting layer, and a lenset layer.

Abstract: A computer-implemented method according to one embodiment includes identifying a plurality of two-dimensional (2D) images illustrating a subject performing a rotation, selecting a representative image of the subject, cropping the plurality of 2D images, utilizing the representative image of the subject, to create a cropped plurality of 2D images, aligning each of the cropped plurality of 2D images, thereby creating an aligned plurality of 2D images, selecting a subset of the aligned plurality of 2D images that illustrate a predetermined amount of rotation of the subject, and creating a three-dimensional (3D) point cloud of the subject, utilizing the subset of the aligned plurality of 2D images.