Abstract: A laser source includes a topological cavity for nonreciprocal lasing, a magnetic material and an optical waveguide. The magnetic material is arranged to interact with the topological cavity. The optical waveguide is arranged to receive light extracted from the topological cavity upon breaking of time-reversal symmetry in the topological cavity.

Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.

Abstract: Methods, devices and systems are described for digitally creating new scents or digitally dispensing gas, vapor, or liquid substances.

Abstract: Continuously monitoring heart rhythm can include grouping, using computer hardware, a plurality of inter-beat intervals (IBI) data for a user into a plurality of epochs, wherein each epoch includes a subset of the IBI data corresponding to a predetermined time span. For each epoch, a selected feature set selected from a plurality of feature sets is extracted based on a determination of temporal consistency of the epoch. A plurality of epoch classifications may be generated for the epochs using a selected feature processor, wherein each epoch classification indicates whether arrhythmia is detected for the epoch from which the epoch classification is generated. The selected feature processor is selected from a plurality of different feature processors on a per-epoch basis based on the selected feature set extracted from the epoch. An indication of arrhythmia may be output, via an output device of the computer hardware, based on the epoch classifications.

Abstract: The present disclosure provides methods for the treatment of a mammal having a neurological condition, disease, or injury. The methods involve increasing the number of functional GABAergic interneurons at or near the site of the neurological disease, injury, or condition.

Abstract: An all-optical hologram reconstruction system and method is disclosed that can instantly retrieve the image of an unknown object from its in-line hologram and eliminate twin-image artifacts without using a digital processor or a computer. Multiple transmissive diffractive layers are trained using deep learning so that the diffracted light from an arbitrary input hologram is processed all-optically to reconstruct the image of an unknown object at the speed of light propagation and without the need for any external power. This passive diffractive optical network, which successfully generalizes to reconstruct in-line holograms of unknown, new objects and exhibits improved diffraction efficiency as well as extended depth-of-field at the hologram recording distance. The system and method can find numerous applications in coherent imaging and holographic display-related applications owing to its major advantages in terms of image reconstruction speed and computer-free operation.

Abstract: The disclosed embodiments relate to multimodal imaging system comprising a fiber-coupled fluorescence imaging system, which operates based on ultra-violet (UV) excitation light, and a fiber-coupled optical coherence tomography (OCT) imaging system. The multimodal imaging system also includes a fiber optic interface comprising a single optical fiber, which facilitates light delivery to a sample-of-interest and collection of returned optical signals for both the fluorescence imaging system and the OCT imaging system. During operation of the system, the single optical fiber carries both UV light and coherent infrared light through two concentric light-guiding regions, thereby facilitating generation of precisely co-registered optical data from the fluorescence imaging system and the OCT imaging system.

Abstract: The present invention provides benzamide compounds, compositions containing the benzamides, and use of the benzamides for inhibiting androgen receptor (AR) and/or aldo-keto reductase family 1 member C3 (AKR1C3). Also described herein methods for the treatment of hormone-mediated diseases and conditions, including hormone-related cancers such as castration resistant prostate cancer.

Abstract: The present disclosure provides synthetic modular polypeptide libraries and nucleic acids encoding such synthetic modular polypeptide libraries. Also provided are methods of making synthetic modular polypeptide libraries and nucleic acids encoding synthetic modular polypeptide libraries. Methods of screening a synthetic modular polypeptide library to identify a selected phenotype associated with a member of a synthetic modular polypeptide library are also provided where such methods find use in both in vitro and in vivo assays.

Abstract: A catalyst composition including nickel foam and a plurality of carbon-doped nickel oxide nanorods disposed on the nickel foam.

Abstract: Disclosed herein are a sulfide-based all-solid-state battery and a method of manufacturing the same, wherein the sulfide-based all-solid-state battery includes a positive electrode active material coated with a lithium niobate precursor, which is manufactured by a polyol process having low production cost, such that it improves safety and increases capacity of the sulfide-based all-solid-state battery.

Abstract: A method of encapsulating a solid sample in a droplet, the method including flowing a continuous phase through a first fluid channel at a first flow rate; flowing a dispersed phase through a second fluid channel at a second flow rate, the dispersed phase including a plurality of particles, cells or beads; trapping the plurality of particles, cells or beads in a mixing region that receives the dispersed phase and the continuous phase; and reducing the first flow rate to encapsulate the trapped particles, cells or beads in droplets of the dispersed phase generated when the dispersed phase and the continuous phase exit the mixing region through an orifice.

Abstract: The present disclosure provides compounds, pharmaceutical compositions, and methods for the treatment of cancer and fibrosis. The disclosed pharmaceutical compositions may include one or more pyrazolyl-containing compounds, or a derivative thereof.

Abstract: The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.

Abstract: Articles of manufacture, including an apparatus for acoustic wave based agglomeration, are provided. The apparatus may include a well and an acoustic wave device. The well may be configured to hold a suspension that includes a plurality of particles. The acoustic wave device may be configured to generate a plurality of acoustic waves. The plurality of acoustic waves inducing acoustic streaming within the suspension. The acoustic streaming agitating the suspension to form an agglomerate comprising at least a portion of the plurality of particles. Methods for acoustic wave based agglomeration are also provided.

Abstract: Divalent ions are extracted from solids by leaching to form a divalent ion-containing solution. The divalent ion-containing solution is subjected to concentration to form a concentrated divalent ion-containing solution. Precipitation of a divalent ion hydroxide salt is induced from the concentrated divalent ion-containing solution. In other cases, the concentrated divalent ion-containing solution is exposed to carbon dioxide to induce precipitation of a divalent ion carbonate salt.

Abstract: The present invention provides methods for improving or accelerating wound healing in a subject comprising administering to a wound of the subject in need thereof an agent that suppresses expression of a clock gene, wherein the clock gene is neuronal PAS domain protein 2 (Npas2). This invention also relates to methods for regenerating alveolar bone, regenerating connective tissue at a wound site, and for decreasing wound area size comprising administering to a bone loss site or a wound site, in particular, an open wound site, of a subject an agent that suppresses expression of Npas2.

Abstract: A terahertz scanner for detecting irregularities, such as chemical or structural variations, in a sample and methods of use thereof are described. The described terahertz scanner and algorithms allow for direct, high-sensitivity, high-throughput, and non-invasive detection of irregularities that range from chemical contaminant to material defects in a variety of substrates and settings.

Abstract: A delivery device or patch is disclosed that includes a detachable hybrid microneedle depot (d-HMND) for cell delivery. The system includes, in one embodiment, an array of microneedles formed from an outer PLGA shell and an internal gelatin methacryloyl (GelMA)-mesenchymal stem cells (MSC) mixture (GMM). The array of microneedles project from a base substrate layer that may be flexible. The therapeutic device may be applied to a tissue site of interest and the base substrate layer is removed leaving the hybrid microneedles in the tissue at the site of application to deliver MSCs. Other stem/therapeutic cells may also be delivered with the hybrid microneedles.

Abstract: A solid state battery is described, which has a negative electrode having a negative electrode active material layer including silicon (Si) as a negative electrode active material. The Si may be present as particles, e.g., microparticles, having an average particle size (D50) of 0.1 ?m to 10 ?m. The negative electrode active material layer may include the silicon (Si) in an amount of 75 wt % or more, 95 wt % or more, 99 wt % or more, or 99.9 wt % or more, based on 100 wt % of the negative electrode active material layer. The negative electrode active material layer can be free or substantially free of conductive material, carbon, solid state electrolyte, and/or binder. Preferably, after charge/discharge cycles, the negative electrode active material layer forms densified and interconnected large particles of Li—Si alloy, e.g., the Li—Si alloy may have at least one columnar structure and at least one void.