Patents Assigned to Regents, University of California
  • Carrier tests for polycystic kidney disease in the cat
    Publication number: 20060110742
    Abstract: The present invention provides compositions and methods for detecting mutations associated with polycystic kidney disease in the cat.
    Type: Application
    Filed: May 28, 2004
    Publication date: May 25, 2006
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Leslie Lyons, Robert Grahn, Carolyn Erdman
  • Synthetic pheromone compositions
    Publication number: 20060110420
    Abstract: The present invention provides compounds useful for preparing synthetic pheromone compositions that can be used as attractants or inhibitors of insect species. The compositions are useful in the control of navel orangeworm or meal moth insect pests.
    Type: Application
    Filed: November 24, 2004
    Publication date: May 25, 2006
    Applicants: The Regents of the University of California, Bedoukian Research, Inc
    Inventors: Walter Leal, Douglas Pesak
  • Fluorescent protein sensors for detection of analytes
    Publication number: 20060112440
    Abstract: Fluorescent indicators including a binding protein moiety, a donor fluorescent protein moiety, and an acceptor fluorescent protein moiety are described. The binding protein moiety has an analyte-binding region which binds an analyte and causes the indicator to change conformation upon exposure to the analyte. The donor moiety and the acceptor moiety change position relative to each other when the analyte binds to the analyte-binding region. The donor moiety and the acceptor moiety exhibit fluorescence resonance energy transfer when the donor moiety is excited and the distance between the donor moiety and the acceptor moiety is small. The indicators can be used to measure analyte concentrations in samples, such as calcium ion concentrations in cells.
    Type: Application
    Filed: January 17, 2006
    Publication date: May 25, 2006
    Applicant: The Regents of the University of California
    Inventors: Roger Tsien, Atsushi Miyawaki
  • Biomarkers for prostate cancer metastasis
    Publication number: 20060110759
    Abstract: The present invention provides genomic markers for determining the predisposition of prostate cancer to become metastasized.
    Type: Application
    Filed: November 4, 2005
    Publication date: May 25, 2006
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Pamela Paris, Colin Collins
  • System and method of all optical label swapping using two-stage optical wavelength converters
    Patent number: 7050717
    Abstract: The present invention disclosed herein therefore provides systems and methods of optical packet switching. The present invention further enables systems and methods of all-optical label swapping (AOLS) with optical subcarrier multiplexed addressing for WDM-IP networks.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: May 23, 2006
    Assignee: The Regents of the University of California
    Inventor: Daniel J. Blumenthal
  • Codoped direct-gap semiconductor scintillators
    Patent number: 7048872
    Abstract: Fast, bright inorganic scintillators at room temperature are based on radiative electron-hole recombination in direct-gap semiconductors, e.g. CdS and ZnO. The direct-gap semiconductor is codoped with two different impurity atoms to convert the semiconductor to a fast, high luminosity scintillator. The codopant scheme is based on dopant band to dopant trap recombination. One dopant provides a significant concentration of carriers of one type (electrons or holes) and the other dopant traps carriers of the other type. Examples include CdS:In,Te; CdS:In,Ag; CdS:In,Na; ZnO:Ga,P; ZnO:Ga,N; ZnO:Ga,S; and GaN:Ge,Mg.
    Type: Grant
    Filed: September 15, 2003
    Date of Patent: May 23, 2006
    Assignee: The Regents of the University of California
    Inventors: Stephen E. Derenzo, Edith Bourret-Courchesne, Marvin J. Weber, Mattias K. Klintenberg
  • High-efficiency spectral purity filter for EUV lithography
    Patent number: 7050237
    Abstract: An asymmetric-cut multilayer diffracts EUV light. A multilayer cut at an angle has the same properties as a blazed grating, and has been demonstrated to have near-perfect performance. Instead of having to nano-fabricate a grating structure with imperfections no greater than several tens of nanometers, a thick multilayer is grown on a substrate and then cut at an inclined angle using coarse and inexpensive methods. Effective grating periods can be produced this way that are 10 to 100 times smaller than those produced today, and the diffraction efficiency of these asymmetric multilayers is higher than conventional gratings. Besides their ease of manufacture, the use of an asymmetric multilayer as a spectral purity filter does not require that the design of an EUV optical system be modified in any way, unlike the proposed use of blazed gratings for such systems.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: May 23, 2006
    Assignee: The Regents of the University of California
    Inventor: Henry N. Chapman
  • Method of defining features on materials with a femtosecond laser
    Patent number: 7049543
    Abstract: The invention relates to a pulsed laser ablation method of metals and/or dielectric films from the surface of a wafer, printed circuit board or a hybrid substrate. By utilizing a high-energy ultra-short pulses of laser light, such a method can be used to manufacture electronic circuits and/or electro-mechanical assemblies without affecting the material adjacent to the ablation zone.
    Type: Grant
    Filed: November 7, 2003
    Date of Patent: May 23, 2006
    Assignee: The Regents of the University of California
    Inventors: Edward Victor Roos, Franklin Roeske, Ronald S. Lee, Jerry J. Benterou
  • Nucleic acids that control seed and fruit development in plants
    Patent number: 7049488
    Abstract: The invention provides methods of controlling endosperm development in plants.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: May 23, 2006
    Assignee: The Regents of the University of California
    Inventors: Robert L. Fischer, Nir Ohad, Tomohiro Kiyosue, Ramin Yadegari, Linda Margossian, John Harada, Robert B. Goldberg
  • Solid phase microextraction fiber cleaning and conditioning apparatus and method
    Patent number: 7047661
    Abstract: A SPME-fiber cleaning and conditioning apparatus and method having an elongated heating chamber with first and second opposite ends. The first end is capable of insertably receiving a SPME fiber portion of a SPME device, and the second end is a fluid outlet. A heater is provided for heating the chamber and heat-treating an inserted SPME fiber. Contaminants and other particles are agitated, desorbed and purged from the inserted SPME fiber by flowing a fluid through the chamber from the first end to the second end, away from the SPME device. Additionally, turbulence may be produced in the flow at a location adjacent the first end, to enhance agitation, desorption, and purging. A holder may also be provided extending from the first end for supporting the SPME device in a substantially horizontal orientation when the SPME fiber is positioned in the chamber.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: May 23, 2006
    Assignee: The Regents of the University of California
    Inventors: Armando Alcaraz, Michael H. Wiefel
  • Color and shape changing polymeric ribbons and sheets
    Patent number: 7049152
    Abstract: The present invention herein provides the design, synthesis and characterization of compositions comprising asymmetric bolaamphiphilic lipids that form extended polymeric ribbons and wide sheets. These compositions may be doped, or interspersed, with various compounds to fine-tune the fluidity and rigidity of the bolaamphiphilic lipid composition, and promote other morphologies of the composition, including fluid vesicles and truncated flat sheets. Upon an increase in pH these compositions undergo a calorimetric and morphological transformation.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: May 23, 2006
    Assignee: The Regents of the University of California
    Inventors: Raymond C. Stevens, Quan Cheng, Jie Song
  • Genes from the 20Q13 amplicon and their uses
    Patent number: 7049424
    Abstract: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: May 23, 2006
    Assignee: The Regents of the University of California
    Inventors: Joe W. Gray, Colin Collins, Soo-in Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
  • Manipulation of live cells and inorganic objects with optical micro beam arrays
    Patent number: 7049579
    Abstract: One or more microbeams derived from a corresponding number of Vertical Cavity Surface Emitting Lasers (VCSELs) are used to manipulate and to transport inorganic and organic objects. The optical tweezing apparatus and method is compact size, and suitable to manipulate multiple objects in an array concurrently, and in parallel.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: May 23, 2006
    Assignee: The Regents of the University of California
    Inventors: Mihrimah Ozkan, Sadik Esener, Mark Wang
  • Minimally invasive glaucoma surgical instrument and method
    Publication number: 20060106370
    Abstract: Apparatuses and methods for the treatment of glaucoma are provided. The instrument uses either cauterization, a laser to ablate, sonic or ultrasonic energy to emulsify, or mechanical cutting of a portion of the trabecular meshwork. The instrument may also be provided with irrigation, aspiration, and a footplate. The footplate is used to enter Schlemm's canal, serves as a guide, and also protects Schlemm's canal.
    Type: Application
    Filed: November 14, 2005
    Publication date: May 18, 2006
    Applicant: The Regents of the University of California
    Inventors: George Baerveldt, Roy Chuck
  • Non-invasive gene targeting to ocular cells
    Publication number: 20060105982
    Abstract: Liposomes containing therapeutic genes are conjugated to multiple targeting agents to provide transport of the encapsulated gene across the blood-retinal barrier and the plasma membrane of ocular cells. Once across the blood-retinal barrier and ocular cell membrane, the encapsulated gene expresses the encoded therapeutic agent within the ocular cells to provide diagnosis and/or treatment of disease.
    Type: Application
    Filed: December 28, 2005
    Publication date: May 18, 2006
    Applicant: The Regents of the University of California
    Inventor: William Pardridge
  • Process for preparing a deuterated or tritiated compound
    Patent number: 7045642
    Abstract: A process for labeling organic compounds with deuterium and tritium is described using specific catalysts.
    Type: Grant
    Filed: May 25, 2004
    Date of Patent: May 16, 2006
    Assignee: The Regents of the University of California
    Inventors: Robert C. Bergman, Steven R. Klei
  • Process for scaled-up production of recombinant proteins using transgenic plant suspension cultures
    Patent number: 7045354
    Abstract: The present invention relates to methods for semi-continuous culture of plant cells in a nutrient medium. The pH of the medium is monitored during the cell culture as a way of monitoring the expression of a product of interest by the cells.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: May 16, 2006
    Assignee: The Regents of the University of California
    Inventors: Karen A. McDonald, Alan P. Jackman, Melody M. Trexler
  • Methods and reagents for targeting organic compounds to selected cellular locations
    Patent number: 7045305
    Abstract: The present invention provides methods and reagents for targeting probes to selected cellular locations, through the expression of specific binding partners to that probe within the cell. In one embodiment, the probes may comprise spectroscopic probe that can be used in a method for localizing a specific binding partner within a cell, and for creating assays for post-translational activities. The invention allows the monitoring of the location of such intracellular specific binding partners over time and in response to stimuli, such as test chemicals. The spectroscopic probes can be used for screening a test chemical for activity. The present invention also includes cells and transgenic organisms comprising the intracellular specific binding partner, wherein the specific binding partner can bind with the spectroscopic probe/ligand conjugate.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: May 16, 2006
    Assignee: The Regents of the University of California
    Inventor: Javier Farinas
  • Radial-radial single rotor turbine
    Patent number: 7044718
    Abstract: A rotor for use in turbine applications has a radial compressor/pump having radially disposed spaced apart fins forming passages and a radial turbine having hollow turbine blades interleaved with the fins and through which fluid from the radial compressor/pump flows. The rotor can, in some applications, be used to produce electrical power.
    Type: Grant
    Filed: July 8, 2003
    Date of Patent: May 16, 2006
    Assignee: The Regents of the University of California
    Inventor: David A. Platts
  • Method and apparatus for adjustably induced biaxial strain
    Patent number: 7044461
    Abstract: An apparatus comprising a shape memory alloy is configured as a ring shaped sample holder for a transmission electron microscope and imparts uniform biaxial strain on a thin film mounted within. The sample holder responds to a change in temperature by changing the inner diameter, which imparts biaxial strain. In other embodiments, the sample holder is configured to change the inner diameter and change the strain on a thin film reversibly and repeatedly. In further embodiments, the sample holder is non circular. In still further embodiments, the apparatus is configured as a prime mover of a reversible radial actuator. Methods for making and using the apparatus are included in other embodiments.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: May 16, 2006
    Assignee: The Regents of the University of California
    Inventors: Michael J. Vestel, Daryl Patrick Oshatz