Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
Type:
Grant
Filed:
March 14, 2017
Date of Patent:
July 19, 2022
Assignees:
Regentys Corporation, University of Pittsburgh—of the Commonwealth System of Higher Education
Inventors:
Marc Ramer, Stephen F. Badylak, Timothy Keane
Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration extracellular matrix hydrogel (ECMH) which stimulates stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
Type:
Application
Filed:
July 7, 2020
Publication date:
April 1, 2021
Applicants:
Regentys Corporation, University of Pittsburgh - Of the Commonwealth System of Higher Education
Inventors:
Marc Ramer, Stephen F. Badylak, Timothy Keane
Abstract: Described are methods and compositions for treatment of reproductive or urogenital mucosal tissue damage using Extracellular Matrix (ECM) solution and, particularly, Extracellular Matrix Hydrogel (ECMH) solution delivered to the target site for tissue repair, restoration, remodeling, or reconstruction.
Type:
Application
Filed:
August 18, 2017
Publication date:
June 20, 2019
Applicant:
Regentys Corporation
Inventors:
Richard Bulman, Christine Sapan, Scott Winston
Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
Type:
Application
Filed:
March 14, 2017
Publication date:
March 14, 2019
Applicants:
Regentys Corporation, University of Pittsburgh - Of the Commonwealth System of Higher Education
Inventors:
Marc Ramer, Stephen F. Badylak, Timothy Keane