Abstract: This invention relates to a novel process for the preparation of Erythromycin aldobionates and novel Erythromycin maltobionates, Erythromycin Cellobionate and Erythromycin mellibionate. The said process comprises converting an alkali metal salt of aldobionic acid into free aldobionic acid, neutralizing the obtained aldobionic acid with Erythromycin base and finally recovering the Erythromycin aldobionate.