Abstract: The invention relates to retinoid compounds of the formula (I): wherein V is a hydrophobic group; W is a non-polyenic linker; and X is a polar group comprising a hydrogen bond donor; or a salt thereof, and to the use of such compounds in the control of cell differentiation.
Type:
Grant
Filed:
August 28, 2007
Date of Patent:
October 23, 2012
Assignee:
Reinnervate Limited
Inventors:
Stefan Przyborski, Andrew Whiting, Todd Marder
Abstract: The invention relates to retinoid compounds of the formula (I): wherein V is a hydrophobic group; W is a non-polyenic linker; and X is a polar group comprising a hydrogen bond donor; or a salt thereof, and to the use of such compounds in the control of cell differentiation.
Type:
Application
Filed:
August 28, 2007
Publication date:
April 15, 2010
Applicant:
REINNERVATE LIMITED
Inventors:
Stefan Przyborski, Andrew Whiting, Todd Marder
Abstract: We describe a cell culture substrate comprising a polymerised high internal phase emulsion polymer adapted and modified for use in the routine culture of cells in three dimensions; typically mammalian cells and the use of the substrate in a cell culture system for investigation and analysis of proliferation, differentiation and function of cells.
Type:
Application
Filed:
April 24, 2007
Publication date:
February 25, 2010
Applicant:
REINNERVATE LIMITED
Inventors:
Stefan Alexander Przyborski, Neil Cameron