Patents Assigned to Reliable Biopharmaceutical Corporation
  • Process for perparing fondaparinux sodium and intermediates useful in the synthesis thereof
    Patent number: 9255119
    Abstract: Processes for the synthesis of the Factor Xa anticoagulent Fondaparinux, and related compounds are described. Also described are protected pentasaccharide intermediates as well as efficient and scalable processes for the industrial scale production of Fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: February 9, 2016
    Assignee: RELIABLE BIOPHARMACEUTICAL CORPORATION
    Inventors: Sourena Nadji, James T. Smoot, Joseph A. Vanartsdalen
  • Efficient and scalable process for the manufacture of fondaparinux sodium
    Patent number: 8987430
    Abstract: The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: March 24, 2015
    Assignee: Reliable Biopharmaceutical Corporation
    Inventors: Payal Parth Patel, Chun Ma, Kevin K. Ohrr, Sourena Nadji
  • PROCESS FOR PERPARING FONDAPARINUX SODIUM AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
    Publication number: 20150018537
    Abstract: Processes for the synthesis of the Factor Xa anticoagulent Fondaparinux, and related compounds are described. Also described are protected pentasaccharide intermediates as well as efficient and scalable processes for the industrial scale production of Fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions.
    Type: Application
    Filed: April 18, 2014
    Publication date: January 15, 2015
    Applicant: Reliable Biopharmaceutical Corporation
    Inventors: Sourena NADJI, James T. Smoot, Joseph A. Vanartsdalen
  • Processes for the preparation of regadenoson and a new crystalline form thereof
    Patent number: 8859522
    Abstract: This disclosure relates to an improved process for the preparation of regadenoson, pharmaceutically acceptable salts thereof, and hydrates thereof, and for the preparation of intermediates useful in the synthesis of regadenoson. The disclosure also relates to a new crystalline form of regadenoson. Processes for the preparation of the crystalline form, compositions containing the crystalline form, and methods of use thereof are also described.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: October 14, 2014
    Assignee: Reliable Biopharmaceutical Corporation
    Inventors: Luzviminda T. Wooldridge, Chun Ma, Sourena Nadji
  • Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof
    Patent number: 8703923
    Abstract: Processes for the synthesis of the Factor Xa anticoagulent Fondaparinux, and related compounds are described. Also described are protected pentasaccharide intermediates as well as efficient and scalable processes for the industrial scale production of Fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: April 22, 2014
    Assignee: Reliable Biopharmaceutical Corporation
    Inventors: Sourena Nadji, James T. Smoot, Joseph A. Vanartsdalen
  • PROCESSES FOR THE PREPARATION OF REGADENOSON AND A NEW CRYSTALLINE FORM THEREOF
    Publication number: 20140045781
    Abstract: This disclosure relates to an improved process for the preparation of regadenoson, pharmaceutically acceptable salts thereof, and hydrates thereof, and for the preparation of intermediates useful in the synthesis of regadenoson. The disclosure also relates to a new crystalline form of regadenoson. Processes for the preparation of the crystalline form, compositions containing the crystalline form, and methods of use thereof are also described.
    Type: Application
    Filed: April 26, 2012
    Publication date: February 13, 2014
    Applicant: Reliable Biopharmaceutical Corporation
    Inventors: Luzviminda T Wooldridge, Chun Ma, Sourena Nadji
  • EFFICIENT AND SCALABLE PROCESS FOR THE MANUFACTURE OF FONDAPARINUX SODIUM
    Publication number: 20130261291
    Abstract: The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.
    Type: Application
    Filed: March 8, 2013
    Publication date: October 3, 2013
    Applicant: Reliable Biopharmaceutical Corporation
    Inventors: Payal Parth PATEL, Chun MA, Kevin K. OHRR, Sourena NADJI
  • PROCESS FOR PERPARING FONDAPARINUX SODIUM AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
    Publication number: 20130102764
    Abstract: Processes for the synthesis of the Factor Xa anticoagulent Fondaparinux, and related compounds are described. Also described are protected pentasaccharide intermediates as well as efficient and scalable processes for the industrial scale production of Fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions.
    Type: Application
    Filed: September 14, 2012
    Publication date: April 25, 2013
    Applicant: Reliable Biopharmaceutical Corporation
    Inventors: Sourena NADJI, James T. Smoot, Joseph A. Vanartsdalen
  • Efficient and scalable process for the manufacture of Fondaparinux sodium
    Patent number: 8420790
    Abstract: The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: April 16, 2013
    Assignee: Reliable Biopharmaceutical Corporation
    Inventors: Payal Parth Patel, Chun Ma, Kevin K. Ohrr, Sourena Nadji
  • Process for preparing Fondaparinux sodium and intermediates useful in the synthesis thereof
    Patent number: 8288515
    Abstract: Processes for the synthesis of the Factor Xa anticoagulent Fondaparinux, and related compounds are described. Also described are protected pentasaccharide intermediates as well as efficient and scalable processes for the industrial scale production of Fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: October 16, 2012
    Assignee: Reliable Biopharmaceutical Corporation
    Inventors: Sourena Nadji, James T. Smoot, Joseph A. Vanartsdalen
  • EFFICIENT AND SCALABLE PROCESS FOR THE MANUFACTURE OF FONDAPARINUX SODIUM
    Publication number: 20120116066
    Abstract: The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.
    Type: Application
    Filed: October 29, 2010
    Publication date: May 10, 2012
    Applicant: Reliable Biopharmaceutical Corporation
    Inventors: Payal P. Patel, Chun Ma, Kevin K. Ohrr, Sourena Nadji
  • PROCESS FOR PREPARING FONDAPARINUX SODIUM AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
    Publication number: 20110105418
    Abstract: Processes for the synthesis of the Factor Xa anticoagulent Fondaparinux, and related compounds are described. Also described are protected pentasaccharide intermediates as well as efficient and scalable processes for the industrial scale production of Fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions.
    Type: Application
    Filed: July 30, 2010
    Publication date: May 5, 2011
    Applicant: Reliable Biopharmaceutical Corporation
    Inventors: Sourena Nadji, James T. Smoot, Joseph A. Vanartsdalen
  • Process for the production of pentostatin aglycone and pentostatin
    Patent number: 7393954
    Abstract: A novel, scaleable and improved process for preparing pentostatin and its analogs is disclosed. The method comprises the diastereospecific synthesis of the nucleobase from commercially available L-Dialkyl tartarates.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: July 1, 2008
    Assignee: Reliable Biopharmaceutical Corporation
    Inventors: Sourena Nadji, James Smoot, UmaShanker Sampath
  • Sulfated acid amides having anticoagulant properties
    Patent number: 5714598
    Abstract: A sulfated acid amide having heparin-like properties of the formula:(R.sub.1)--NH--R--NH--(R.sub.1)where R.sub.1 is a di-, tri- or tetra-saccharide acid selected from cellobiose, cellotriose, cellotetrose, maltose, maltotriose and maltotetrose or mixtures thereof, and R is an alkylene of from 3 to 12 carbons, and is optionally substituted with one or more hydroxyls.
    Type: Grant
    Filed: October 4, 1995
    Date of Patent: February 3, 1998
    Assignee: Reliable Biopharmaceutical Corporation
    Inventor: Joseph A. Toce
  • Sulfated acid amides having anticoagulant properties
    Patent number: 5589588
    Abstract: A sulfated acid amide having heparin-like properties of the formula:(R.sub.1)--NH--R--NH--(R.sub.1)whereR.sub.1 is a di-, tri- or tetra-saccharide acid selected from cellobiose, cellotriose, cellotetrose, maltose, maltotriose and maltotetrose or mixtures thereof, andR is an alkylene of from 3 to 12 carbons, and is optionally substituted with one or more hydroxyls.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: December 31, 1996
    Assignee: Reliable Biopharmaceutical Corporation
    Inventor: Joseph A. Toce