Patents Assigned to Relypsa, Inc.
  • METHODS AND COMPOSITIONS FOR SELECTIVELY REMOVING POTASSIUM ION FROM THE GASTROINTESTINAL TRACT OF A MAMMAL
    Publication number: 20140044804
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
    Type: Application
    Filed: October 15, 2013
    Publication date: February 13, 2014
    Applicant: Relypsa, Inc.
    Inventors: Michael J. Cope, Paul Mansky, Futian Liu, Han-Ting Chang, Dominique Charmot, Eric Connor, Kalpesh Biyani, Mingjun Liu, Tony Kwok-Kong Mong, Yan Chen
  • Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
    Patent number: 8617609
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: December 31, 2013
    Assignee: Relypsa, Inc.
    Inventors: Michael J. Cope, Paul Mansky, Futian Liu, Han-Ting Chang, Dominique Charmot, Eric Connor, Kalpesh Biyani, Mingjun Liu, Tony Kwok-Kong Mong, Yan Chen
  • Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
    Patent number: 8586097
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: November 19, 2013
    Assignee: Relypsa, Inc.
    Inventors: Futian Liu, Han-Ting Chang, Dominique Charmot, Eric Connor, Paul Mansky, Mingjun Liu
  • METHODS AND COMPOSITIONS FOR SELECTIVELY REMOVING POTASSIUM ION FROM THE GASTROINTESTINAL TRACT OF A MAMMAL
    Publication number: 20130259949
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
    Type: Application
    Filed: May 24, 2013
    Publication date: October 3, 2013
    Applicant: Relypsa, Inc.
    Inventors: Michael J. Cope, Paul Mansky, Futian Liu, Han-Ting Chang, Dominique Charmot, Eric Connor, Kalpesh Biyani, Mingjun Liu, Tony Kwok-Kong Mong, Yan Chen
  • CONTINUOUS PROCESS FOR PREPARING POLYFLUOROACRYLATE PARTICLES
    Publication number: 20130197170
    Abstract: The present invention is directed to a continuous process for preparing a crosslinked polymer comprising a fluoro group.
    Type: Application
    Filed: March 18, 2011
    Publication date: August 1, 2013
    Applicant: RELYPSA, INC.
    Inventor: George Tyson
  • POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS
    Publication number: 20130189215
    Abstract: The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
    Type: Application
    Filed: February 24, 2011
    Publication date: July 25, 2013
    Applicant: RELYPSA, INC.
    Inventors: Inez Lees, Kalpesh Biyani, Eric Connor, Scott Hecker, Hongmin Zhang, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao, Xinnan Zhang
  • LINEAR POLYOL STABILIZED POLYFLUOROACRYLATE COMPOSITIONS
    Publication number: 20130189216
    Abstract: The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
    Type: Application
    Filed: March 12, 2013
    Publication date: July 25, 2013
    Applicant: RELYPSA, INC.
    Inventor: Relypsa, Inc.
  • Ion binding polymers and uses thereof
    Patent number: 8475780
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: July 2, 2013
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han-Ting Chang, Gerrit Klaerner, Jerry M. Buysse, Mingjun Liu
  • LINEAR POLYOL STABILIZED POLYFLUOROACRYLATE COMPOSITIONS
    Publication number: 20130131202
    Abstract: The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
    Type: Application
    Filed: December 18, 2012
    Publication date: May 23, 2013
    Applicant: RELYPSA, INC.
    Inventor: Relypsa, Inc.
  • Ion binding compositions
    Patent number: 8445014
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: May 21, 2013
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han-Ting Chang, Eric Connor, Mingjun Liu, Gerrit Klaerner
  • Methods and compositions for treatment of ion imbalances
    Patent number: 8409561
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: April 2, 2013
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han-Ting Chang, Mingjun Liu, Futian Liu, Gerrit Klaerner
  • CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS
    Publication number: 20130022570
    Abstract: The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
    Type: Application
    Filed: February 24, 2011
    Publication date: January 24, 2013
    Applicant: RELYPSA, INC.
    Inventors: Jordan Kopping, Kalpesh Biyani, Eric Connor, Scott Hecker, Inez Lees, Grace Quaker, Faleh Salaymeh, Hongmin Zhang, David Bergbreiter, Paul Mansky, YongQi Mu, Michael James Cope, Elizabeth Goka, Angela Lee, Deidre Madsen, Jun Shao
  • Linear polyol stabilized polyfluoroacrylate compositions
    Patent number: 8337824
    Abstract: The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
    Type: Grant
    Filed: August 22, 2009
    Date of Patent: December 25, 2012
    Assignee: Relypsa, Inc.
    Inventors: Detlef Albrecht, Michael Burdick, Han-Ting Chang, Dominique Charmot, Ramakrishnan Chidambaram, Eric Connor, Sherin Halfon, I-Zu Huang, Mingjun Liu, Jonathan Mills, Werner Strüver
  • Ion binding polymers and uses thereof
    Patent number: 8287847
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: October 16, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han-Ting Chang, Mingjun Liu, Gerrit Klaerner
  • Ion binding polymers and uses thereof
    Patent number: 8282913
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: October 9, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han-Ting Chang, Mingjun Liu, Gerrit Klaerner
  • Ion binding compositions
    Patent number: 8282960
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: October 9, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, John Fordtran, Han Ting Chang, Eric Connor, Mingjun Liu, Gerrit Klaerner
  • Ion binding polymers and uses thereof
    Patent number: 8216560
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: July 10, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han Ting Chang, John Fordtran, Gerrit Klaerner, Jerry M. Buysse, Robert Alpern, Mingjun Liu
  • Ion binding compositions
    Patent number: 8192758
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: June 5, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, John Fordtran, Han Ting Chang, Eric Connor, Mingjun Liu, Gerrit Klaerner
  • POWDER FORMULATIONS OF POTASSIUM-BINDING ACTIVE AGENTS
    Publication number: 20120107381
    Abstract: The present invention is directed to powder formulations of a potassium-binding active agent, a suspending agent, and a glidant; optionally, other excipients can be added to the formulations. These formulations can be in a powder form and are useful to bind potassium in the gastrointestinal tract.
    Type: Application
    Filed: May 13, 2010
    Publication date: May 3, 2012
    Applicant: RELYPSA, INC.
    Inventors: Dasharatha Reddy, George Tyson
  • Methods and compositions for treatment of ion imbalances
    Patent number: 8147873
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: April 3, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Mingjun Liu