Abstract: A blister collation system includes a blister packager with a blister seal station which seals a blister package with a medicament inside and a blister package stacker connected to the blister packager via a conveyor which moves individual blister packages. The blister package stacker has a nest inlet for reception of the blister packages from the conveyor, a nest assembly for holding one of the blister packages, and a first blister package collection tower for storing a stack of the blister packages. The nest assembly is configured to insert one blister package at a time upward into a bottom of the first collection tower. The stacker further has a tower gate holding the inserted blister packages and a mechanism for pushing the stack of the blister packages from the first collection tower into a storage container.

Abstract: Disclosed herein is a method of treating an aqueous solution containing impurities including a perfluoroalkyl substance and/or a polyfluoroalkyl substance, comprising introducing the aqueous solution into a batch or semi-batch photocatalytic reactor with a microparticulate catalyst configured to reduce chain length of the perfluoroalkyl substance and/or polyfluoroalkyl substance, forming a treated aqueous stream, the reactor including a catalyst flow controller configured to automatically increase the catalyst concentration in the reactor while agitating the catalyst-containing solution during reaction, and removing catalyst particles from the treated aqueous stream to form a purified aqueous stream. In some cases, the feed to the reactor is atomized.

Abstract: The present inventive concept provides a voltage generating apparatus for X-rays including a console that receives an X-ray irradiation signal to generate a control signal and detects the X-ray irradiation signal to generate a first detection signal, a pulse control unit that receives the control signal and the first detection signal from the console to generate a second detection signal and generates a pulse signal according to the control signal and the second detection signal, and a high voltage generating unit that generates a high voltage according to the pulse signal from the pulse control unit, and an X-ray generating apparatus having the same.

Abstract: A package insert module that includes a turntable configured to rotate about a central post and an insert assembly mounted on the turntable and including a finger arrangement configured to offload a plurality of packages arranged in an array on a nest.

Abstract: A method of remediation of soil and groundwater containing hydrocarbons and halogenated compounds. The method includes introducing a remediation composition into the soil that includes: (a) a first bioremediation material including a first blend of organisms capable of degrading the hydrocarbons; (b) a second bioremediation material including a second blend of organisms differing from the first blend of organisms that is chosen for degrading the halogenated compounds; (c) an organic compound such as a complex carbohydrate (e.g., food grade starch); and (d) a third blend of organisms degrading the organic compound. The degrading of the organic compound breaks the complex carbohydrate into smaller molecules that are utilized by the microorganisms of at least one of the first and second bioremediation materials during the degrading of the hydrocarbons and the halogenated compounds.

Abstract: Disclosed are methods of treating a subject having a disease or disorder by administering a monoamine oxidase inhibitor in combination with a serotonin receptor agonist, which in some embodiments is a deuterated serotonin receptor agonist. In some aspects, the disclosure further relates to pharmaceutical compositions and kits comprising a monoamine oxidase inhibitor and a serotonin receptor agonist. In some embodiments, the monoamine oxidase inhibitor is a MAO-A-selective inhibitor such as CX157, and the serotonin receptor agonist is a serotonin 2A receptor agonist such as N,N-dimethyltryptamine (DMT), or deuterated DMT.

Abstract: According to the present inventive concept, there is provided an X-ray generating apparatus including a voltage generating apparatus that generates a pulse signal according to an X-ray irradiation signal and generates a predetermined voltage according to the pulse signal, and an X-ray tube that generates X-rays according to the voltage from the voltage generating apparatus, wherein the voltage generating apparatus detects arc discharge by detecting a current of the X-ray tube.

Abstract: An automation apparatus for dispensing groups of individually packaged products including a storage module including a first storage bin configured to slidably receive a storage tube inserted therein; a first storage tube configured to store therein a plurality of products each contained in an individual package, the first storage tube including an end cap including a release slot to allow movement of a first individual package along a direction transverse to a longitudinal axis of the first storage tube for removal of the first individual package from the storage tube, the end cap including a retention slot configured to engage with a registration pin of the first storage bin and prevent the first storage tube from sliding out of the first storage bin; and a pick device configured to retrieve the first individual package from the first storage tube disposed in the end cap via the release slot.

Abstract: A blister collation system includes a blister packager with a blister seal station which seals a blister package with a medicament inside and a blister package stacker connected to the blister packager via a conveyor which moves individual blister packages. The blister package stacker has a nest inlet for reception of the blister packages from the conveyor, a nest assembly for holding one of the blister packages, and a first blister package collection tower for storing a stack of the blister packages. The nest assembly is configured to insert one blister package at a time upward into a bottom of the first collection tower. The stacker further has a tower gate holding the inserted blister packages and a mechanism for pushing the stack of the blister packages from the first collection tower into a storage container.

Abstract: System for guiding an instrument within a vascular network of a patient are disclosed. In some embodiments, the system receives a medical image from a medical imaging device and identifies a distal tip and a direction the instrument in the image. The system may then determine a waypoint for the distal tip of the instrument based at least in part on the position and direction of the distal tip of the instrument. The system may then generate a trajectory command for moving the instrument through the vascular network from the current position to the waypoint. The system may operate in a closed loop. The system may provide the trajectory command to a robotic medical system configured to move the instrument according to the command.

Abstract: An automation apparatus for dispensing groups of individually packaged products, the apparatus including a storage arrangement adapted to store a plurality of products each contained in an individual package. The storage arrangement includes a first module and a second module, where the first module is adapted to store products having a first frequency demand threshold and the second module is adapted to store products having a second frequency demand threshold that is lower than the first frequency demand threshold. The apparatus further includes a plurality of fixed first discharge assemblies adapted to move selected ones of the individual packages from the first module of the storage arrangement and a second discharge assembly comprising a moveable pick device adapted to move selected ones of the individual packages out of the second module of the storage arrangement.

Abstract: Disclosed herein is a method of remediating chromated copper arsenate (CCA) treated timber. Particularly, the method comprises contacting the CCA timber with an oxidative solvent and an acidic solvent which provides remediated timber and a variety of extracts containing amongst other things the metals of concern. One or more of the steps is conducted using continuous counter current extraction (CCE).

Abstract: Disclosed are compounds, methods, compositions, uses, and kits that modulate (e.g., inhibit) nicotinamide phosphoribosyltransferase (NAMPT), the production of nicotinamide mononucleotide (NMN), the production of nicotinamide adenine dinucleotide (NAD), NAMPT signaling, a NAMPT pathway, and/or cellular metabolism. In some embodiments, the compounds are used to treat diseases or disorders. The compounds may treat cancer by targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, lymphoma, liver cancer, endometrial cancer, leukemia, or multiple myeloma. Further provided are methods of manufacturing compounds of Formula (V).

Abstract: A method and apparatus is disclosed for separating an amount of a perfluoroalkyl or polyfluoroalkyl substance (PFAS) from water which is contaminated with the substance. The method comprises the steps of: admitting an amount of the water, which includes an initial concentration of the substance, into a chamber via an inlet thereinto, and introducing a flow of gas into the chamber. The introduced gas induces the water in the chamber to flow, and produces a froth layer which is formed at, and which rises above, an interface with the said flow of water and of introduced gas in the chamber. The froth layer includes an amount of water, and also a concentrated amount of the substance in comparison compared with its initial concentration. The step of removal of at least some of the froth layer from an upper portion of the chamber occurs.

Abstract: Systems and methods for vision-based position and orientation determination for endovascular tools are disclosed. In one example, a method includes receiving a two-dimensional medical image including a view of at least a distal portion of a medical instrument, the distal portion of the medical instrument including one or more fiducials positioned thereon, the one or more fiducials being radio-opaque and visible in the medical image. The method also includes detecting, within the medical image, a two-dimensional appearance of the one or more fiducials, and based on the two-dimensional appearance of the one or more fiducials, determining at least one of a roll angle of the distal portion of the medical instrument, and an incline of the distal portion of the medical instrument.

Abstract: A composition for remediation of soil and groundwater containing halogenated compounds. The remediation composition includes an elemental iron-based composition, which may include activated carbon capable of absorbing the halogenated compounds with numerous pores impregnated with elemental iron. The remediation composition further includes a first bioremediation material including a blend of one-to-many organisms capable of degrading the halogenated compounds. The remediation composition includes an organic compound or polymeric substance and a second bioremediation material including a blend of one-to-many organisms capable of degrading the organic compound or polymeric substance over time (e.g., 20 to 365 or more days to provide a time release substrate-creating material or platform) into smaller molecules or compounds used by the organisms in the first bioremediation material while degrading the halogenated compounds.

Abstract: A pharmacy system and methodology for individually packaged medications and/or supplements assembled into an order for each patient which can be delivered to a long-term care facility or other institution for patient consumption. The process may include receiving a patient's prescription order, automatically dispensing packaged unit doses, and assembling into individually packaged bags for each patient. Various safeguards and measures built into this system and method increase patient safety, eliminate waste, and increase labor efficiency by reducing and/or minimizing the disposal of unused medications and supplements.

Abstract: The present invention relates to a human MRPL15-derived cell-penetrating peptide and a cargo-molecule delivery system using the same, and provides a method for delivering cargo molecules into a cell, the method comprising a step for bringing a cargo-molecule transduction domain including the human MRPL15-derived RMMR1 or a variant resulting from substitution or deletion thereof and a recombinant cargo molecule fused with the cargo molecule transduction domain into contact with cells, wherein the cargo molecule transduction domain of the present invention not only can introduce cargo molecules into cells at a higher efficiency than existing cell-penetrating peptides, but is a polypeptide sequence derived from human proteins, and thus also has no risk of causing immune response problems. Thus the cargo molecule transduction domain is useful for delivering various polymer materials into human cells.

Abstract: The present invention relates to a human ADARB2-derived cell-penetrating peptide and a cargo-molecule delivery system using the same, and provides a method for delivering cargo molecules into a cell, the method comprising a step for bringing a cargo-molecule transduction domain including the human ADARB2-derived RMAD1 or a variant thereof and a recombinant cargo molecule fused with the cargo molecule transduction domain into contact with cells. The cargo molecule transduction domain of the present invention not only can introduce cargo molecules into cells at a higher efficiency than existing cell-penetrating peptides, but is a polypeptide sequence derived from human proteins, and thus also has no risk of causing immune response problems. Thus the cargo molecule transduction domain is useful for delivering various polymer materials into human cells.

Abstract: A package insert module that includes a turntable configured to rotate about a central post and an insert assembly mounted on the turntable and including a finger arrangement configured to offload a plurality of packages arranged in an array on a nest.