Patents Assigned to Rempex Pharmaceuticals, Inc.
  • Tetracycline compositions
    Patent number: 9084802
    Abstract: The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: July 21, 2015
    Assignee: REMPEX PHARMACEUTICALS, INC.
    Inventors: David C. Griffith, Serge Boyer, Scott Hecker, Michael N. Dudley
  • METHODS OF TREATING BACTERIAL INFECTIONS
    Publication number: 20150119363
    Abstract: The present invention relates to compounds, compositions and methods for treating bacterial infections. Embodiments of the present invention include antibiotics and ?-lactamase inhibitors to treat resistant infections.
    Type: Application
    Filed: February 11, 2013
    Publication date: April 30, 2015
    Applicant: Rempex Pharmaceuticals, Inc..
    Inventors: Michael N. Dudley, Scott Hecker, Olga Rodny
  • Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 9012491
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronate compounds and their use as therapeutic agents.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: April 21, 2015
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Raja K. Reddy, Serge Henri Boyer, Maxim Totrov, Scott Hecker
  • Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
    Patent number: 8933018
    Abstract: Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: January 13, 2015
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Tomasz Glinka, Robert Higuchi, Scott Hecker, Brian Eastman, Olga Rodny
  • Aminoglycoside derivatives
    Patent number: 8906868
    Abstract: The present invention relates to antimicrobial agents. Some embodiments include compounds, compositions, methods of preparation, and methods of treatment using new aminoglycosides and aminoglycoside derivatives.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: December 9, 2014
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Tomasz W. Glinka, Olga Rodny
  • HETEROCYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20140206648
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronate compounds and their use as therapeutic agents.
    Type: Application
    Filed: August 30, 2012
    Publication date: July 24, 2014
    Applicant: REMPEX PHARMACEUTICALS, INC.
    Inventors: Raja K. Reddy, Serge Henri Boyer, Maxim Totrov, Scott Hecker
  • BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20140194381
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
    Type: Application
    Filed: March 14, 2013
    Publication date: July 10, 2014
    Applicant: Rempex Pharmaceuticals, Inc.
    Inventor: Rempex Pharmaceuticals, Inc.
  • TETRACYCLINE COMPOSITIONS
    Publication number: 20140194393
    Abstract: The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.
    Type: Application
    Filed: March 11, 2014
    Publication date: July 10, 2014
    Applicant: Rempex Pharmaceuticals, Inc.
    Inventors: David C. Griffith, Serge Boyer, Scott Hecker, Michael N. Dudley
  • Cyclic boronic acid ester derivatives and therapeutic uses thereof
    Patent number: 8680136
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: March 25, 2014
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20130345172
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: July 29, 2013
    Publication date: December 26, 2013
    Applicant: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF
    Publication number: 20130316943
    Abstract: Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.
    Type: Application
    Filed: February 6, 2012
    Publication date: November 28, 2013
    Applicant: REMPEX PHARMACEUTICALS, INC.
    Inventors: Tomasz Glinka, Robert Higuchi, Scott Hecker, Brian Eastman, Olga Rodny
  • AMINOGLYCOSIDE DERIVATIVES
    Publication number: 20130059808
    Abstract: The present invention relates to antimicrobial agents. Some embodiments include compounds, compositions, methods of preparation, and methods of treatment using new aminoglycosides and aminoglycoside derivatives.
    Type: Application
    Filed: May 12, 2011
    Publication date: March 7, 2013
    Applicant: Rempex Pharmaceuticals, Inc.
    Inventors: Tomasz W. Glinka, Olga Rodny
  • TETRACYCLINE COMPOSITIONS
    Publication number: 20130040918
    Abstract: The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.
    Type: Application
    Filed: October 17, 2012
    Publication date: February 14, 2013
    Applicant: Rempex Pharmaceuticals, Inc.
    Inventor: Rempex Pharmaceuticals, Inc.
  • Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof
    Patent number: 8268865
    Abstract: Disclosed are compounds having at least one quaternary alkyl ammonium functionality. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
    Type: Grant
    Filed: May 6, 2008
    Date of Patent: September 18, 2012
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Tomasz Glinka, Olga Lomovskaya, Keith Bostian, David M. Wallace
  • Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
    Patent number: 8178490
    Abstract: Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: May 15, 2012
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Tomasz Glinka, Olga Rodny, Keith A. Bostian, David M. Wallace, Robert I. Higuchi, Chun Chow, Chi Ching Mak, Gavin Hirst, Brian Eastman
  • CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20120040932
    Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.
    Type: Application
    Filed: August 8, 2011
    Publication date: February 16, 2012
    Applicant: Rempex Pharmaceuticals, Inc.
    Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
  • Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
    Patent number: 7994225
    Abstract: Efflux pump inhibitors are co-administered with antimicrobial agents for the treatment of ophthalmic or otic infections. The agents may be co-administered directly to the site of infection (e.g., the eye or ear).
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: August 9, 2011
    Assignee: Rempex Pharmaceuticals, Inc.
    Inventors: Keith Bostian, Tomasz Glinka, Olga Lomovskaya, Mark Surber, Neil Berkley, David Griffith