Abstract: Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.

Abstract: Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators occur, or during events that do induce or have the potential for inducing abnormal production of pro-inflammatory or anti-inflammatory stimulators or mediators. The devices, systems, and methods serve to prevent, control, reduce, or alleviate the severity of the inflammatory response and disease states that are associated with abnormal levels of or unregulated or excessive interaction among pro-inflammatory or anti-inflammatory stimulators or mediators.

Abstract: A method of peritoneal dialysis includes introducing a dialysis solution into a peritoneal cavity; allowing the dialysis solution to dwell in the peritoneal cavity for a period of time to provide diffusion through an inner lining of an abdominal cavity with exchange of components between a microcirculation of a peritoneum and a dialysis fluid; withdrawing the dialysis solution from the peritoneal cavity with toxins; passing the dialysis solution with toxins through an absorbent polymeric material which has a size, shape, and structure selected so as to remove the toxins in a molecular range of 300-30,000 Dalton from the spent dialysis solution; and returning the thusly purified peritoneal dialysis solution to the patient.

Abstract: A method of producing a device for purifying blood from toxins includes providing a container with an inlet and outlet, preparing a mixture of a porous beaded adsorbent polymeric material with a liquid, and supplying the mixture under the pressure through the inlet into the interior of the container so that liquid is squeezed out of the mixture and leaves the container through the outlet, while the beads of the beaded polymeric material are homogeneously and densely packed in an interior of the container.