Abstract: A device for removing fluid from a body, the device comprising an array of microneedles and a housing; the array of microneedles being disposed within the housing and the housing defining a chamber. The microneedles are moveable between a disengaged position and an engaged position where, in use in the engaged position, the microneedles penetrate the surface of a body. The chamber is adapted to surround the surface of the body through which the microneedles penetrate when in the engaged position. The chamber is configured for connection to a vacuum device such that negative pressure can be applied to the chamber.

Abstract: A device for removing fluid from a body, the device comprising an array of microneedles and a housing; the array of microneedles being disposed within the housing and the housing defining a chamber. The microneedles are moveable between a disengaged position and an engaged position where, in use in the engaged position, the microneedles penetrate the surface of a body. The chamber is adapted to surround the surface of the body through which the microneedles penetrate when in the engaged position. The chamber is configured for connection to a vacuum device such that negative pressure can be applied to the chamber.

Abstract: A fluid extraction or filtration device for removing fluid from a body, the device comprising an array of microneedles for contacting fluid in said body and an absorbent gel matrix in fluid communication with said array of microneedles. There is further provided a combined fluid extraction and sampling device and methods employing the device(s), for example in determining the level of a target species in a sample of fluid, transdermal dialysis and renal replacement therapy. There is further provided an absorbent gel matrix for use in the treatment of uraemia and a haemodialysis filter comprising an absorbent gel matrix. Use of such a matrix is described in the context of methods including haemodialysis, transdermal dialysis and gastrointestinal dialysis.

Abstract: A fluid extraction or filtration device for removing fluid from a body, the device comprising an array of microneedles for contacting fluid in said body and an absorbent gel matrix in fluid communication with said array of microneedles. There is further provided a combined fluid extraction and sampling device and methods employing the device(s), for example in determining the level of a target species in a sample of fluid, transdermal dialysis and renal replacement therapy. There is further provided an absorbent gel matrix for use in the treatment of uraemia and a haemodialysis filter comprising an absorbent gel matrix. Use of such a matrix is described in the context of methods including haemodialysis, transdermal dialysis and gastrointestinal dialysis.

Abstract: A fluid extraction or filtration device for removing fluid from a body, the device comprising an array of microneedles for contacting fluid in said body and an absorbent gel matrix in fluid communication with said array of microneedles. There is further provided a combined fluid extraction and sampling device and methods employing the device(s), for example in determining the level of a target species in a sample of fluid, transdermal dialysis and renal replacement therapy. There is further provided an absorbent gel matrix for use in the treatment of uraemia and a haemodialysis filter comprising an absorbent gel matrix. Use of such a matrix is described in the context of methods including haemodialysis, transdermal dialysis and gastrointestinal dialysis.