Abstract: A particle size sensor for metallic powder includes a microwave cavity or waveguide, the microwave cavity or waveguide including a microwave source for generating microwaves within the microwave cavity or waveguide, a microwave receiver for detecting microwaves generated within the cavity or waveguide, a sample insertion point for receiving a sample of the metallic powder and an analyser arranged to determine a particle size for the metallic powder from receiver signals generated by the receiver.

Abstract: A method of monitoring an additive manufacturing process, in which an object is built in a layer-by-layer manner by directing a laser beam using at least one movable guiding element of a scanner to solidify selected regions of a material bed. The method includes recording position values generated from a transducer measuring positions of the at least one movable guiding element, recording sensor values generated from a sensor for detecting radiation emitted from the material bed and transmitted to the sensor by the movable guiding element of the scanner, and associating each sensor value with a corresponding one of the position values.

Abstract: An additive manufacturing apparatus for building objects by layerwise consolidation of material. The apparatus includes a build chamber containing a working area, a plurality of high energy beams for consolidating material deposited in the working area in layers and an optical unit for controlling transmission of the high energy beams onto material in the working area. The optical unit includes a plurality of independently controllable optical elements each optical element for controlling transmission of at least one of the high energy beams onto the material in the working area, the optical unit movable in the build chamber.

Abstract: A machine tool is provided with a toolsetting probe mounted on a bed or table, and a workpiece-sensing probe which can be mounted in a movable spindle. Both probes are calibrated by using them to make measurements against each other. The arbitrary length of the workpiece-sensing probe is used to calibrate the toolsetting probe, rather than using a pre-calibrated artefact of known length mounted in the spindle. A stylus disc of the toolsetting probe has a pre-calibrated size or dimension, and the workpiece-sensing probe is calibrated with respect to that. This obviates the need for skilful manual calibration procedures using pre-calibrated artefacts and manual measurement tools.

Abstract: A selective laser solidification apparatus including; a powder bed onto which powder layers can be deposited, at least one laser module for generating a plurality of laser beams for solidifying the powder material deposited onto the powder bed, a laser scanner for individually steering each laser beam to solidify separate areas in each powder layer, and a processing unit. A scanning zone for each laser beam is defined by the locations on the powder bed to which the laser beam can be steered by the laser scanner. The laser scanner is arranged such that each scanning zone is less than the total area of powder bed and at least two of the scanning zones overlap. The processing unit is arranged for selecting, for at least one powder layers, which laser beam to use to scan an area of the powder layer located within a region wherein the seaming zones overlap.

Abstract: A method of manufacturing an article including taking an article in an initial state formed using an additive manufacturing process, the article including at least one set of mounting features; performing a second manufacturing process to transform the article into a second state, which includes mounting, via the at least one set of mounting features, the article in a holding device of a machine for operating on the article, wherein the position and orientation of the article in three linear and three rotational degrees of freedom within the machine operating volume is known and defined by virtue of the interaction of the mounting features with the holding device, and processing at least one feature on the article. The at least one mounting feature includes kinematic mount features which engage with corresponding kinematic mount features on the holding device of the machine.

Abstract: A method for delivering fluid to the brain of a subject using an intraparenchymal catheter, the method comprising the step of inserting the catheter into the brain using a posterior to anterior approach and methods of treating neurodegenerative disorders using this delivery method, as well as methods for delivering fluid to an elongate structure of the brain using an intraparenchymal catheter, the method comprising the step of inserting a catheter into the brain along an insertion axis that is substantially aligned with a long axis of the elongate structure.

Abstract: The invention concerns a cranial drill system comprising one or more surgical drill elements for drilling into the brain. The invention also concerns a cranial drilling system comprising a surgical drill element for drilling into the skull and an element for penetrating the dura. The surgical drill element may comprise a profile that forms an opening in the skull having a narrower diameter portion and a wider diameter portion and the piercing element may be arranged to be a close fit in the narrower diameter portion of the opening. The invention also concerns a cranial drill system comprising a guiding element to be located in a hole formed through the skull and a piercing element for piercing the dura. The guiding element may have a passageway or channel therein for receiving the piercing element such that the piercing element is movable relative to the guide element to pierce the dura.

Abstract: This invention concerns spectroscopy apparatus comprising a light source arranged to generate a light profile on a sample, a photodetector having at least one photodetector element for detecting characteristic light generated from interaction of the sample with light from the light source, a support for supporting the sample, the support movable relative to the light profile, and a processing unit. The processing unit is arranged to associate a spectral value recorded by the photodetector element at a particular time with a point on the sample predicted to have generated the characteristic light recorded by the photodetector element at the particular time based on. relative motion anticipated to have occurred between the support and the light profile.

Abstract: A selective laser solidification apparatus including; a powder bed onto which powder layers can be deposited, at least one laser module for generating a plurality of laser beams for solidifying the powder material deposited onto the powder bed, a laser scanner for individually steering each laser beam to solidify separate areas in each powder layer, and a processing unit. A scanning zone for each laser beam is defined by the locations on the powder bed to which the laser beam can be steered by the laser scanner. The laser scanner is arranged such that each scanning zone is less than the total area of powder bed and at least two of the scanning zones overlap. The processing unit is arranged for selecting, for at least one powder layers, which laser beam to use to scan an area of the powder layer located within a region wherein the scanning zones overlap.

Abstract: This invention concerns an additive manufacturing apparatus for building objects by layerwise consolidation of material. The apparatus includes a build chamber containing a working area, a high energy beam for consolidating material deposited in the working area in layers and a flow device for generating a gas flow across at least a part of the working area from a gas inlet to a gas outlet. The gas inlet and gas outlet are arranged to be movable within the build chamber.

Abstract: A method is described for measuring an object using a machine tool and a scanning probe. The scanning probe is driven along a scan path relative to the object whilst the scanning probe acquires probe data describing a series of positions on the surface of the object relative to the scanning probe. The scan path includes at least a first scan path segment for producing probe data that can be analysed to measure the object. The scan path is also arranged to impart a plurality of identifiable probe motions to the scanning probe that can be identified from the acquired probe data alone. Each identifiable probe motion is used to define a time stamp. This allows the probe data to be tied to commanded or nominal positions around the scan path.

Abstract: A percutaneous fluid access apparatus includes a percutaneous fluid access device. The percutaneous fluid access device has a base portion including a subcutaneous portion and at least one port for connection to one or more fluid conduits within a body of a patient. A housing has at least one fluid channel and at least one seal for sealing the at least one fluid channel, and the housing is removably attachable to the base portion. The at least one fluid channel is in fluid communication with the at least one port when the housing is attached to the base portion.

Abstract: A method of putting a feature of interest on an object and an optical inspection system of a non-contact probe mounted on a positioning apparatus in a desired relationship. The method includes: a) identifying a target point of interest on the object to be inspected by arranging the non-contact probe and object at a first relative configuration at which a marker feature, projected by the non-contact probe along a projector axis that is not coaxial with the optical inspection system's optical axis, identifies the target point of interest; and b) subsequently moving the non-contact probe and/or object so as to put them at a second relative configuration at which the target point of interest and optical inspection system are at the desired relationship, in which the positioning apparatus is configured to guide such motion in accordance with the control path.

Abstract: A non-Cartesian coordinate positioning machine that includes an extendable leg assembly for positioning a component such as a measurement probe within a working volume of the machine. The extendable leg assembly includes a first member and a second member which move relative to one another when the extendable leg assembly changes length. The first member including an axial arrangement of magnets forming part of a linear motor for extending and retracting the extendable leg assembly, and at least one resilient member for absorbing at least some of any axial thermal expansion or contraction of the magnets in use.

Abstract: An encoder apparatus comprising a scale comprising scale features in at least one track which define a series of incremental scale marks and at least one reference mark and a readhead comprising a light source, a diffraction grating, an incremental photodetector and a reference photodetector comprising at least two detector channels. The features defining the at least one reference mark are configured such that the at least one reference mark as resolvable by each of the at least two detector channels comprises a single feature. The optical arrangement of the encoder is such that a non-imaged representation of at least the track in which the at least one reference mark is contained falls onto the detector.

Abstract: A method of treating a CNS disorder. The method comprises providing a water-soluble histone deacetylase inhibitor, and administering the water-soluble histone deactylase inhibitor directly into a brain via convection enhanced delivery.

Abstract: A method for determining an attribute of an additive manufacturing apparatus including a plurality of scanners, each scanner including beam steering optics for directing a corresponding radiation beam to a working plane in which material consolidated in layers. The method may include controlling the beam steering optics of a pair of the scanners wherein a first scanner of the pair directs a radiation beam to form a feature in the working plane. The feature is within a field of view of a detector of the second scanner of the pair, the detecting radiation from the working plane is collected by the beam steering optics of the second scanner. Further including recording at least one detector value with the detector of the second scanner for the field of view and determining an attribute of the additive manufacturing apparatus from a comparison of the detector value with an expected detector value.

Abstract: An apparatus and methods for generating geometric data for use in an additive manufacturing process. The apparatus includes a processing unit. The processing unit may be arranged for receiving data defining surface geometry of a plurality of objects to be built together in an additive manufacturing process, providing a user interface that allows a user to define a location of each object within a common build volume and carrying out a slicing operation on at least one of the objects located in the common build volume independently from another one of objects located in the common build volume. The slicing operation determines sections of the at least one object to be built in the additive manufacturing process. In one embodiment, the objects are defined in a hierarchical data structure. Supports for supporting the objects during the build may be defined with reference to a 2-dimensional support cross-section.

Abstract: A method of inspecting an object with a camera probe for capturing an image of an object, the camera probe being movable along a path by a measurement apparatus, at least a part of the camera probe being rotatable about at least one axis. The method includes: a) the measurement apparatus moving the camera probe relative to the object along an inspection path and b) for at least one period as the camera probe moves along the inspection path: turning at least a part of the camera probe about the at least one axis thereby slowing the passage of a feature of interest on the object across the camera probe's field of view; and capturing at least one image of the feature of interest during at least a portion of the turning.