Patents Assigned to Renopharm Ltd.
  • Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
    Patent number: 8134010
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: March 13, 2012
    Assignee: Renopharm Ltd.
    Inventor: Peter Assaf
  • Nitric oxide donors and uses thereof
    Patent number: 7968575
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: June 28, 2011
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having alkyl substituent(s) and uses thereof
    Patent number: 7579477
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: August 25, 2009
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof
    Patent number: 7498445
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: March 3, 2009
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based Nitric Oxide donors having Acyl substuent(s) and uses thereof
    Publication number: 20080233163
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: March 24, 2008
    Publication date: September 25, 2008
    Applicant: Renopharm Ltd.
    Inventor: Peter Assaf
  • Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
    Patent number: 7368577
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: May 6, 2008
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having acyl substituent(s) and uses thereof
    Patent number: 7332513
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: February 19, 2008
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof
    Patent number: 7189750
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: March 13, 2007
    Assignee: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Nitric oxide donors and uses thereof
    Publication number: 20070021382
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: May 5, 2005
    Publication date: January 25, 2007
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
    Publication number: 20060183718
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: November 4, 2005
    Publication date: August 17, 2006
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof
    Publication number: 20060183912
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: November 4, 2005
    Publication date: August 17, 2006
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having acyl substuent(s) and uses thereof
    Publication number: 20060183913
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: November 4, 2005
    Publication date: August 17, 2006
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors having alkyl substuent(s) and uses thereof
    Publication number: 20060069138
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: November 4, 2005
    Publication date: March 30, 2006
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh
  • Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof
    Publication number: 20060069139
    Abstract: Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.
    Type: Application
    Filed: November 4, 2005
    Publication date: March 30, 2006
    Applicant: Renopharm Ltd.
    Inventors: Peter Assaf, Elham Gazaleen-Mariee, Michael Naveh