Abstract: The invention provides pharmaceutical compositions comprising TGF-? superfamily members and sugars, the compositions allowing improved recovery and/or increased biological activity of the TGF-? superfamily member incorporated therein. The invention also relates to uses of sugars to improve the recovery or increase the biological activity of TGF-? superfamily members in a pharmaceutical composition. Uses of the pharmaceutical compositions are also described, particularly with reference to wound healing and fibrosis. Furthermore, the invention discloses medicaments for the prevention or reduction of injection pain.

Abstract: The invention relates to the use of TGF-?3, or agents having TGF-?3 activity, to promote epithelial regeneration. Methods of manufacturing medicaments, and methods of promoting epithelial regeneration are both provided. In particular, the medicaments and methods of treatment of the invention are applicable to the promotion of epithelial regeneration in healthy patients, and/or in acute wounds.

Abstract: The invention provides pharmaceutical compositions comprising TGF-? superfamily members and sugars, the compositions allowing improved recovery and/or increased biological activity of the TGF-? superfamily member incorporated therein. The invention also relates to uses of sugars to improve the recovery or increase the biological activity of TGF-? superfamily members in a pharmaceutical composition. Uses of the pharmaceutical compositions are also described, particularly with reference to wound healing and fibrosis. Furthermore, the invention discloses medicaments for the prevention or reduction of injection pain.

Abstract: The use of Matrix Metalloproteinase Inhibitors in the prevention or treatment of connective tissue softening and also for the maintenance of sutures in such connective tissues. The connective tissue may be a tendon, ligament or cartilage.