Abstract: Described are compositions containing quinones that show activity in enhance DNA repair and/or prevent damage to DNA and/or upregulate genes associated with wound healing. The quinones are thymoquinone, lapachol, myrtucommulone C, or mixtures thereof, and can be formulated into cosmetic compositions for topical administration to a subject in need thereof. The cosmetic compositions can also include sunscreens, surfactants, sunless tanning agents, desquamation agents, antiperspirants, colorants, preservatives and mixtures; and a cosmetically acceptable carrier. The compositions should find use in methods for treating the signs of ageing in mammals, dermatitis and wound healing via topical application to a site in need thereof, such as the skin or hair of the mammals or a wound site.
Type:
Grant
Filed:
May 3, 2018
Date of Patent:
May 25, 2021
Assignees:
Repairogen Corp., University of Louisville Research Foundation, Inc., Cornell University
Inventors:
Michael Boice, Frank Borchetta, Albert Cunningham, John Trent, Pengbo Zhou, Chenyi Yang
Abstract: Described are compositions containing quinones that show activity in enhance DNA repair and/or prevent damage to DNA. The quinones are thymoquinone, lapachol, myrtucommulone C, or mixtures thereof, and can be formulated into cosmetic compositions for topical administration to a subject in need thereof. The cosmetic compositions can also include sunscreens, surfactants, sunless tanning agents, desquamation agents, antiperspirants, colorants, preservatives and mixtures; and a cosmetically acceptable carrier. The compositions should find use in methods for treating the signs of ageing in mammals via topical application to the skin or hair of the mammals.
Type:
Grant
Filed:
November 3, 2017
Date of Patent:
September 22, 2020
Assignees:
REPAIROGEN CORP., UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC., CORNELL UNIVERSITY
Inventors:
Michael Boice, Frank Borchetta, Albert Cunningham, John Trent, Pengbo Zhou, Chenyi Yang