Patents Assigned to Replidyne, Inc.
  • Antibacteriall heterocyclic ureas
    Patent number: 8716320
    Abstract: The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: May 6, 2014
    Assignee: Replidyne, Inc.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun
  • BACTERIAL REPLICATION SYSTEMS AND METHODS
    Publication number: 20100028862
    Abstract: Reconstituted bacterial replication assemblies and methods for their use are provided.
    Type: Application
    Filed: April 26, 2005
    Publication date: February 4, 2010
    Applicant: Replidyne,Inc.
    Inventors: Thale Cross Jarvis, Charles S. McHenry, Nebojsa Janjic, Garry Dallmann, James M. Bullard, Stacie Bell, Glenn Sanders, Frank Dean
  • Transition metal catalyzed cross-coupling of 1-halo-1-haloalkene compounds
    Publication number: 20090054667
    Abstract: Methods for introducing a 1-halo-1-haloalkene compound onto an aromatic or heteroaromatic ring are provided, including processes for the production of certain 1-halovinyl aryl or heteroaryl derivatives in which the 1-halovinyl group is either 1-fluoro or 1-chlorovinyl and the aromatic species phenyl or thiophene, the processes including coupling an arylmagnesium species with a dihalo olefin in the presence of a nickel or iron catalyst.
    Type: Application
    Filed: August 9, 2006
    Publication date: February 26, 2009
    Applicant: Replidyne, Inc.
    Inventors: Joseph W. Guiles, Jian Qiu, Theodore M. Tarasow
  • Antibacterial heterocyclic ureas
    Publication number: 20080207703
    Abstract: The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same.
    Type: Application
    Filed: July 23, 2007
    Publication date: August 28, 2008
    Applicant: Replidyne, Inc.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun
  • Methionyl tRNA synthetase polynucleotides
    Patent number: 7361476
    Abstract: The invention provides metS polypeptides and DNA (RNA) encoding metS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: April 22, 2008
    Assignee: Replidyne, Inc.
    Inventor: Elizabeth Jane Lawlor
  • tRNA synthetase
    Patent number: 7335499
    Abstract: The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: February 26, 2008
    Assignee: Replidyne, Inc.
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • tRNA synthetases, metRS
    Publication number: 20070292921
    Abstract: The invention relates to metRS polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques. Also disclosed are methods for utilizing metRS polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: August 2, 2006
    Publication date: December 20, 2007
    Applicant: Replidyne, Inc.
    Inventors: Philip Hayes, Daniel Gentry, Stephanie Van Horn
  • metRS2
    Patent number: 7304152
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: December 4, 2007
    Assignee: Replidyne, Inc.
    Inventors: Daniel R Gentry, David J Holmes, Karen A Ingraham
  • 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY
    Publication number: 20070213362
    Abstract: A method of inhibiting MetRS activity comprises administering to a patient in need thereof a MetRS inhibiting effective amount of a compound of the formula (I). A method of treating a resistant or multiply-resistant E. faecalis infection, a resistant or multiply-resistant S. aureus infection, and/or a resistant or multiply-resistant S. epidermidis infection comprises administering to a patient in need thereof an antibacterially effective amount of a compound of the formula (I).
    Type: Application
    Filed: May 21, 2007
    Publication date: September 13, 2007
    Applicant: Replidyne, Inc.
    Inventors: John Berge, Andrew Forrest, Dieter Hamprecht, Richard Jarvest
  • Compositions and methods for topical administration of 2-NH-heteroarylimidazoles
    Patent number: 7220757
    Abstract: Compounds of formula (I): are inhibitors of bacterial methionyl tRNA synthetase and are of use in treating bacterial infections.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: May 22, 2007
    Assignee: Replidyne, Inc.
    Inventors: John Berge, Andrew Forrest, Dieter Hamprecht, Richard Jarvest
  • metRS2
    Publication number: 20070009993
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.
    Type: Application
    Filed: June 16, 2006
    Publication date: January 11, 2007
    Applicant: Replidyne, Inc.
    Inventors: Daniel Gentry, David Holmes, Karen Ingraham
  • metRS2
    Patent number: 7128920
    Abstract: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infestations in materials.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: October 31, 2006
    Assignee: Replidyne, Inc.
    Inventors: Daniel R Gentry, David J Holmes, Karen A Ingraham
  • tRNA synthetases, metRS
    Patent number: 7087417
    Abstract: The invention relates to metRS polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques. Also disclosed are methods for utilizing metRS polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: August 8, 2006
    Assignee: Replidyne, Inc.
    Inventors: Philip David Hayes, Daniel R Gentry, Stephanie Van Horn
  • Substituted thiophenes with antibacterial activity
    Patent number: 7030137
    Abstract: Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: April 18, 2006
    Assignee: Replidyne, Inc.
    Inventors: John Berge, Richard Jarvest, Catherine Simone Victoire Frydrych, Joseph Guiles, Jian Qiu, Theodore M. Tarasow
  • Methionyl tRNA synthetase polypeptides from Staphylococcus aureus
    Patent number: 6989255
    Abstract: The invention provides methionyl tRNA synthetase (tRS) enzymes from Staphylococcus aureus and methods of producing such tRS by recombinant techniques. Also provided are methods for utilizing tRS for the protection against infection, particularly bacterial infection, most particularly Staphylococcus aureus infection.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: January 24, 2006
    Assignee: Replidyne, Inc.
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • 2-NH-heteroarylimidazoles with antibacterial activity
    Patent number: 6943175
    Abstract: Compounds of formula (I): are inhibitors of bacterial methionyl tRNA synthetase and are of use in treating bacterial infections.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: September 13, 2005
    Assignee: Replidyne, Inc.
    Inventors: John Berge, Andrew Forrest, Dieter Hamprecht, Richard Jarvest
  • Polynucleotides encoding methionyl tRNA synthetase from Staphylococcus aureus, related products and methods
    Patent number: 6903204
    Abstract: The invention provides Staphylococcus aureus methionyl tRNA synthetase polypeptides and DNA (RNA) encoding Staphylococcus aureus methionyl tRNA synthetase polypeptides and methods for producing such poypeptides by recombinant techniques. Also provided are methods for utilizing Staphylococcus aureus methionyl tRNA synthetase polypeptides for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: June 7, 2005
    Assignee: Replidyne, Inc.
    Inventors: John Edward Hodgson, Elizabeth Jane Lawlor
  • 2-NH-heteroarylimidazoles with antibacterial activity
    Publication number: 20040147548
    Abstract: Compounds of formula (I): 1
    Type: Application
    Filed: December 5, 2003
    Publication date: July 29, 2004
    Applicant: Replidyne, Inc.
    Inventors: John Berge, Andrew Forrest, Dieter Hamprecht, Richard Jarvest
  • Thermophilic polymerase III holoenzyme
    Patent number: 6677146
    Abstract: The present invention relates to gene and amino acid sequences encoding DNA polymerase III holoenzyme subunits and structural genes from thermophilic organisms. In particular, the present invention provides DNA polymerase III holoenzyme subunits and accessory proteins of T. thermophilus. The present invention also provides antibodies, primers, probes, and other reagents useful to identify DNA polymerase III molecules.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: January 13, 2004
    Assignee: Replidyne, Inc.
    Inventors: Nebojsa Janjic, James M. Bullard, Charles S. McHenry, Vladimir Kery