Abstract: Prothymosin expression is up-regulated in endometriotic tissue. This invention provides methods of diagnosing endometriosis by detecting up-regulation of a prothymosin gene product, and methods of treating endometriosis by down-regulating expression of prothymosin in ectopic or eutopic endometriotic tissue.
Type:
Grant
Filed:
December 27, 2000
Date of Patent:
June 22, 2004
Assignee:
Reprogen, Inc.
Inventors:
Patrick A. Schneider, Cynthia K. French, Karen K. Yamamoto
Abstract: This invention provides methods for diagnosing and treating endometriosis, and promoting implantation of an embryo. The methods involve determining or modulating antileukoprotease activity in a subject.
Abstract: The invention provides an endometriosis mouse model wherein severely compromised immune deficient (SCID) female mice are transplanted with human xenografts of normal endometrial tissue, but result in mice with human endometriosis. Typically, the xenografts are treated with a micronized estrogen source prior to transplantation or implantation and the endogenous progesterone of the mice is eliminated also prior to transplantation of the human xenograft. These diseased mice are useful in the study of endometriosis.
Type:
Grant
Filed:
March 25, 1998
Date of Patent:
August 6, 2002
Assignees:
Reprogen, Inc., The Trustees of the Universiy of Pennsylvania
Inventors:
Jeffrey Boyd, Jerome J. Strauss, Peter Van Deerlin, Karen K. Yamamoto
Abstract: Cathepsin S expression is up-regulated in endometriotic tissue. This invention provides methods of diagnosing endometriosis by detecting up-regulation of a cathepsin S gene product, and methods of treating endometriosis by down-regulating expression of cathepsin S in ectopic or eutopic endometriotic tissue.
Type:
Grant
Filed:
March 26, 2001
Date of Patent:
May 14, 2002
Assignee:
Reprogen, Inc.
Inventors:
Patrick Schneider, Karen K. Yamamoto, Cynthia K. French
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