Patents Assigned to Repros Therapeutics Inc.
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Patent number: 10561624Abstract: The present invention relates to the use of compositions comprising trans-clomiphene for treating men with hypogonadism. The invention is also directed to methods for treating males with hypogonadism.Type: GrantFiled: August 17, 2016Date of Patent: February 18, 2020Assignee: REPROS THERAPEUTICS INC.Inventor: Joseph S. Podolski
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Patent number: 10328022Abstract: The subject matter of the present invention is pertinent to the field of vaginal delivery of pharmaceutically active agents. Embodiments of the instant invention disclose methods for treating a variety of progesterone related disorders by vaginal administration of a pullulan capsule comprising one or more antiprogestins.Type: GrantFiled: May 30, 2013Date of Patent: June 25, 2019Assignee: REPROS THERAPEUTICS INC.Inventors: Joseph S. Podolski, Kuang Hsu
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Patent number: 9981906Abstract: The present invention relates to substantially pure metabolites of irara-clomiphene. The invention is also directed to pharmaceutical compositions comprising these metabolites and their use in treating disorders including secondary hypogonadism, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostate hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.Type: GrantFiled: August 3, 2012Date of Patent: May 29, 2018Assignee: Repros Therapeutics Inc.Inventors: Joseph S. Podolski, Ronald D. Wiehle
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Patent number: 9914696Abstract: The present invention provides a one-pot method for synthesizing clomiphene (a mixture of the isomers cis-clomiphene and trans-clomiphene) utilizing a single solvent. In a preferred embodiment, the single solvent is dichloromethane (DCM, also known as methylene chloride). The present invention provides an improved method for synthesizing clomiphene and purifying clomiphene isomers.Type: GrantFiled: March 9, 2015Date of Patent: March 13, 2018Assignee: Repros Therapeutics Inc.Inventors: Joseph S. Podolski, Kuang Hsu
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Publication number: 20170189421Abstract: The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention concerns methods of treating estrogen-dependent conditions such as endometrial hyperplasia and endometrial cancer in a female undergoing estrogen and/or selective estrogen receptor modulator (SERM) therapy. The instant invention is also relevant to the suppression of endometrial proliferation. The instant invention is also relevant to the treatment of pain associated with endometriosis. The compositions for practicing the methods, comprising progesterone antagonists are also disclosed. Embodiments of the instant invention also disclose methods for identifying new selective progesterone receptor modulators for practicing disclosed methods of treatment.Type: ApplicationFiled: March 21, 2017Publication date: July 6, 2017Applicant: REPROS THERAPEUTICS INC.Inventor: Joseph S. Podolski
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Publication number: 20170181965Abstract: The subject matter of the present invention is pertinent to the field of vaginal delivery of pharmaceutically active agents. Embodiments of the instant invention disclose methods for treating a variety of progesterone related disorders by vaginal administration of a pullulan capsule and a fill formulation comprising one or more antiprogestins dispersed in a mixture of isopropyl palmitate or isopropyl myristate and a polyethylene glycol.Type: ApplicationFiled: April 22, 2015Publication date: June 29, 2017Applicant: REPROS THERAPEUTICS INC.Inventors: Joseph S. PODOLSKI, Kuang HSU
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Patent number: 9687458Abstract: The present invention relates to the administration of compositions comprising an antiestrogen, preferably a selective estrogen receptor modulator (SERM) such as trans-clomiphene, for treating cancer and associated diseases. The invention is also directed to methods for reducing IGF-1 levels in a subject in need thereof by administering a composition comprising an antiestrogen, preferably a SERM such as trans-clomiphene.Type: GrantFiled: October 22, 2013Date of Patent: June 27, 2017Assignee: Repros Therapeutics Inc.Inventors: Joseph S. Podolski, Ronald D. Wiehle, Kuang Hsu, Greg Fontenot
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Patent number: 9616034Abstract: The present invention relates to the administration of compositions comprising trans-clomiphene or an analog or salt thereof, for inhibiting bone resorption and bone turnover in a subject. The invention is also directed to methods for increasing bone mineral density in a subject and preventing or treating a bone related disorder in a subject comprising administering to the subject an effective amount of trans-clomiphene or an analog or salt thereof.Type: GrantFiled: June 3, 2014Date of Patent: April 11, 2017Assignee: REPROS THERAPEUTICS INC.Inventors: Joseph S. Podolski, Kuang Hsu, Ronald D. Wiehle, Greg Fontenot, Jaye Thompson
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Patent number: 9616074Abstract: The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention concerns methods of treating estrogen-dependent conditions such as endometrial hyperplasia and endometrial cancer in a female undergoing estrogen and/or selective estrogen receptor modulator (SERM) therapy. The instant invention is also relevant to the suppression of endometrial proliferation. The instant invention is also relevant to the treatment of pain associated with endometriosis. The compositions for practicing the methods, comprising progesterone antagonists are also disclosed. Embodiments of the instant invention also disclose methods for identifying new selective progesterone receptor modulators for practicing disclosed methods of treatment.Type: GrantFiled: April 11, 2014Date of Patent: April 11, 2017Assignee: REPROS THERAPEUTICS INC.Inventor: Joseph S. Podolski
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Publication number: 20170073302Abstract: The present invention provides a one-pot method for synthesizing clomiphene (a mixture of the isomers cis-clomiphene and trans-clomiphene) utilizing a single solvent. In a preferred embodiment, the single solvent is dichloromethane (DCM, also known as methylene chloride). The present invention provides an improved method for synthesizing clomiphene and purifying clomiphene isomers.Type: ApplicationFiled: March 9, 2015Publication date: March 16, 2017Applicant: REPROS THERAPEUTICS INC.Inventors: Joseph S. PODOLSKI, Kuang HSU
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Patent number: 9545411Abstract: The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. Methods for treating these conditions are provided comprising systemically administering an antiprogestin and contemporaneously locally administering an antiprogestin. Embodiments of the instant invention disclose methods for treating endometriosis, dysmenorrhea, breast cancer, uterine fibroids and endometrial hyperproliferation.Type: GrantFiled: October 22, 2013Date of Patent: January 17, 2017Assignee: REPROS THERAPEUTICS INC.Inventors: Joseph S. Podolski, Ronald D. Wiehle
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Publication number: 20160354325Abstract: The present invention relates to the use of compositions comprising trans-clomiphene for treating men with hypogonadism. The invention is also directed to methods for treating males with hypogonadism.Type: ApplicationFiled: August 17, 2016Publication date: December 8, 2016Applicant: REPROS THERAPEUTICS INC.Inventor: Joseph S. PODOLSKI
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Publication number: 20160346295Abstract: The present invention relates to the long-term administration of a selective estrogen receptor modulator (SERM) with a short half-life for the treatment of a variety of estrogen receptor-mediated conditions. The SERM may be administered at a concentration at or below that of a SERM with a long half-life in order to achieve an equivalent therapeutic effect.Type: ApplicationFiled: August 12, 2016Publication date: December 1, 2016Applicant: REPROS THERAPEUTICS INC.Inventors: Joseph S. PODOLSKI, Ronald D. WIEHLE
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Publication number: 20160128953Abstract: The present invention relates to the administration of compositions comprising trans-clomiphene or an analogue or salt thereof, for inhibiting bone resorption and bone turnover in a subject. The invention is also directed to methods for increasing bone mineral density in a subject and preventing or treating a bone related disorder in a subject comprising administering to the subject an effective amount of trans-clomiphene or an analogue or salt thereof.Type: ApplicationFiled: June 3, 2014Publication date: May 12, 2016Applicant: REPROS THERAPEUTICS INC.Inventors: Joseph S. PODOLSKI, Kuang HSU, Ronald D. WIEHLE, Greg FONTENOT, Jaye THOMPSON
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Patent number: 9283234Abstract: The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention concerns methods of treating estrogen-dependent conditions such as endometrial hyperplasia and endometrial cancer in a female undergoing estrogen and/or selective estrogen receptor modulator (SERM) therapy. The instant invention is also relevant to the suppression of endometrial proliferation. The instant invention is also relevant to the treatment of pain associated with endometriosis. The compositions for practicing the methods, comprising progesterone antagonists are also disclosed. Embodiments of the instant invention also disclose methods for identifying new selective progesterone receptor modulators for practicing disclosed methods of treatment.Type: GrantFiled: October 24, 2007Date of Patent: March 15, 2016Assignee: REPROS THERAPEUTICS INC.Inventor: Joseph S. Podolski
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Publication number: 20160038506Abstract: The present invention relates to the long-term administration of a selective estrogen receptor modulator (SERM) with a short half-life for the treatment of a variety of estrogen receptor-mediated conditions. The SERM may be administered at a concentration at or below that of a SERM with a long half-life in order to achieve an equivalent therapeutic effect.Type: ApplicationFiled: October 19, 2015Publication date: February 11, 2016Applicant: REPROS THERAPEUTICS INC.Inventors: Joseph S. Podolski, Ronald D. Wiehle
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Publication number: 20150297612Abstract: The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. Methods for treating these conditions are provided comprising systemically administering an antiprogestin and contemporaneously locally administering an antiprogestin. Embodiments of the instant invention disclose methods for treating endometriosis, dysmenorrhea, breast cancer, uterine fibroids and endometrial hyperproliferation.Type: ApplicationFiled: October 22, 2013Publication date: October 22, 2015Applicant: REPROS THERAPEUTICS INC.Inventors: Joseph S. PODOLSKI, Ronald D. WIEHLE
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Patent number: 9161940Abstract: The present invention relates to the long-term administration of a selective estrogen receptor modulator (SERM) with a short half-life for the treatment of a variety of estrogen receptor-mediated conditions. The SERM may be administered at a concentration at or below that of a SERM with a long half-life in order to achieve an equivalent therapeutic effect.Type: GrantFiled: February 14, 2013Date of Patent: October 20, 2015Assignee: REPROS THERAPEUTICS INC.Inventors: Joseph S. Podolski, Ronald D. Wiehle
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Publication number: 20150283099Abstract: The present invention relates to the administration of compositions comprising an antiestrogen, preferably a selective estrogen receptor modulator (SERM) such as trans-clomiphene, for treating cancer and associated diseases. The invention is also directed to methods for reducing IGF-1 levels in a subject in need thereof by administering a composition comprising an antiestrogen, preferably a SERM such as trans-clomiphene.Type: ApplicationFiled: October 22, 2013Publication date: October 8, 2015Applicant: REPROS THERAPEUTICS INC.Inventors: Joseph S. Podolski, Ronald D. Wiehle, Kuang Hsu, Greg Fontenot
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Publication number: 20150265553Abstract: The present invention relates to the use of compositions comprising trans-clomiphene for treating men with hypogonadism. The invention is also directed to methods for treating males with hypogonadism.Type: ApplicationFiled: June 9, 2015Publication date: September 24, 2015Applicant: REPROS THERAPEUTICS INC.Inventor: Joseph S. Podolski