Abstract: The present invention provides a recombinant expression vector comprising a gene encoding canine parvovirus 2a VP2 or 2b VP2 protein, a recombinant plant into which the vector is transformed, a vaccine composition against canine parvovirus, comprising canine parvovirus 2a VP2 or 2b VP2 protein obtained from the recombinant plant, and a composition for diagnosing canine parvovirus. When the recombinant plant of the present invention is used, canine parvovirus 2a VP2 or 2b VP2 antigen protein can be rapidly produced with high efficiency. Since the composition for diagnosing canine parvovirus according to the present invention uses a recombinant antigen protein, there is no possibility of contamination due to live virus handling, and thus the composition is safe, and the presence or absence of canine parvovirus infection can be rapidly diagnosed from a large amount of samples.
Type:
Grant
Filed:
April 17, 2020
Date of Patent:
April 16, 2024
Assignees:
REPUBLIC OF KOREA(ANIMAL AND PLANT QUARANTINE AGENCY), BIOAPPLICATIONS INC.
Inventors:
In-Ohk Ouh, Jae-Young Song, Ju-Yeon Lee, Soo Dong Cho, Jienny Lee, Yongjik Lee
Abstract: Provided is a swine fever antigen fused with a porcine Fc fragment, and more particularly, to a vaccine composition having an autoimmune-enhancing effect by binding the Fc fragment to a swine fever antigen, and a preparation method thereof.
Type:
Grant
Filed:
September 16, 2019
Date of Patent:
November 1, 2022
Assignees:
BIOAPPLICATIONS INC., REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE
AGENCY)
Inventors:
Yongjik Lee, Dong-Jun An, Se Eun Choe, Jae-Young Song, In-Soo Cho
Abstract: The present invention relates to a vaccine composition comprising a Staphylococcus aureus attenuated enterotoxin protein and cytotoxin protein, and more particularly to a Staphylococcus aureus enterotoxin protein, a Staphylococcus aureus cytotoxin protein, a vaccine composition for prevention of bovine mastitis, comprising the Staphylococcus aureus enterotoxin protein and Staphylococcus aureus cytotoxin protein and a method for preventing bovine mastitis comprising administering the vaccine composition to a bovine.
Type:
Application
Filed:
March 4, 2022
Publication date:
August 4, 2022
Applicants:
REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY), Mississippi State University
Inventors:
Dong Chan MOON, Suk Kyung LIM, Keum Chan JANG, Suk Chan JUNG, Hee Soo LEE, Bang Hun HYUN, Hyang Mi NAM, Heui Jin KIM, Keun Seok Seo
Abstract: The present invention relates to a vaccine composition comprising a Staphylococcus aureus attenuated enterotoxin protein and cytotoxin protein, and more particularly to a Staphylococcus aureus enterotoxin protein, a Staphylococcus aureus cytotoxin protein, a vaccine composition for prevention of bovine mastitis, comprising the Staphylococcus aureus enterotoxin protein and Staphylococcus aureus cytotoxin protein and a method for preventing bovine mastitis comprising administering the vaccine composition to a bovine.
Type:
Application
Filed:
December 13, 2018
Publication date:
June 10, 2021
Applicants:
REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY), Mississippi State University
Inventors:
Dong Chan MOON, Suk Kyung LIM, Keum Chan JANG, Suk Chan JUNG, Hee Soo LEE, Bang Hun HYUN, Hyang Mi NAM, Heui Jin KIM, Keun Seok Seo
Abstract: Provided is a swine fever antigen fused with a porcine Fc fragment, and more particularly, to a vaccine composition having an autoimmune-enhancing effect by binding the Fc fragment to a swine fever antigen, and a preparation method thereof.
Type:
Application
Filed:
September 16, 2019
Publication date:
September 17, 2020
Applicants:
BIOAPPLICATIONS INC., REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY)
Inventors:
Yongjik LEE, Dong-Jun AN, Se Eun CHOE, Jae-Young SONG, In-Soo CHO
Abstract: A recombinant vector for transforming a plant, a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein expressed in the plant and uses thereof is provided. By using a recombinant vector having a polynucleotide encoding a GP55 protein of CSFV according to the present invention; and a polynucleotide encoding a cellulose-binding domain protein; and a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein may be produced with high efficiency, and has higher safety and stability than those achieved by other production methods. Also, since the plant-derived classical swine fever virus antigen protein pmE2 has a cellulose-binding domain (CBD) protein, it may be usefully used as an effective marker to determine a virus exposure pathway and an antibody producing pathway.
Type:
Grant
Filed:
May 12, 2016
Date of Patent:
July 9, 2019
Assignees:
BIO APPLICATIONS INC., REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY)
Inventors:
Dong Jun An, Seong In Lim, Jae Young Song, Hye Young Jeoung, Eun Ju Sohn, In Hwan Hwang, Nam Jo Park, Yong Jik Lee, Nam Hyung Kim, Sung Min Gu
Abstract: A recombinant vector for transforming a plant, a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein expressed in the plant and uses thereof is provided. By using a recombinant vector having a polynucleotide encoding a GP55 protein of CSFV according to the present invention; and a polynucleotide encoding a cellulose-binding domain protein; and a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein may be produced with high efficiency, and has higher safety and stability than those achieved by other production methods. Also, since the plant-derived classical swine fever virus antigen protein pmE2 has a cellulose-binding domain (CBD) protein, it may be usefully used as an effective marker to determine a virus exposure pathway and an antibody producing pathway.
Type:
Application
Filed:
May 12, 2016
Publication date:
October 25, 2018
Applicants:
BIOAPPLICATIONS INC., REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY)
Inventors:
Dong Jun AN, Seong In LIM, Jae Young SONG, Hye Young JEOUNG, Eun Ju SOHN, In Hwan HWANG, Nam Jo PARK, Yong Jik LEE, Nam Hyung KIM, Sung Min GU