Patents Assigned to Requis Pharmaceuticals
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Publication number: 20220133741Abstract: The present invention provides for novel combinations comprising an antihistamine with selected pharmaceutical and nutraceutical agents which alleviate some of the symptoms experienced by menopausal women, optionally combined further with a range of indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin. These mixtures may be enriched further with pharmaceutically acceptable calcium and magnesium salts as well as selected B vitamins. These combinations have utility in providing a medicament for improving health in mammals, especially for the improvement of menopausal symptoms as well as sleep in women.Type: ApplicationFiled: January 17, 2022Publication date: May 5, 2022Applicant: Requis PharmaceuticalsInventors: Lars Jacob Stray Knutsen, Judith Lois Knutsen, Mark A. Pimley
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Patent number: 11224603Abstract: The present invention provides for novel combinations comprising an antihistamine with selected pharmaceutical and nutraceutical agents which alleviate some of the symptoms experienced by menopausal women, optionally combined further with a range of indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin. These mixtures may be enriched further with pharmaceutically acceptable calcium and magnesium salts as well as selected B vitamins. These combinations have utility in providing a medicament for improving health in mammals, especially for the improvement of menopausal symptoms as welt as sleep in women.Type: GrantFiled: December 13, 2014Date of Patent: January 18, 2022Assignee: REQUIS PHARMACEUTICALS, INC.Inventors: Lars Jacob Stray Knutsen, Judith Lois Knutsen, Mark A. Pimley
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Publication number: 20190008188Abstract: The present invention provides combinations comprising a sedating antihistamine and selected indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin, along with pharmaceutically acceptable calcium and magnesium salts and selected B vitamins. These combinations are useful in providing a medicament for improving sleep in mammals, especially humans.Type: ApplicationFiled: September 13, 2018Publication date: January 10, 2019Applicant: Requis PharmaceuticalsInventors: Lars Jacob Stray Knutsen, Judi Lois Knutsen
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Publication number: 20170280749Abstract: The present invention provides combinations comprising a sedating antihistamine and selected indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin, along with pharmaceutically acceptable calcium and magnesium salts and selected B vitamins. These combinations are useful in providing a medicament for improving sleep in mammals, especially humans.Type: ApplicationFiled: June 12, 2017Publication date: October 5, 2017Applicant: Requis PharmaceuticalsInventors: Lars Jacob Stray Knutsen, Judi Lois Knutsen, James M HAND
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Patent number: 9700548Abstract: The present invention provides combinations comprising a sedating antihistamine and selected indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin, along with pharmaceutically acceptable calcium and magnesium salts and selected B vitamins. These combinations are useful in providing a medicament for improving sleep in mammals, especially humans.Type: GrantFiled: June 8, 2012Date of Patent: July 11, 2017Assignee: REQUIS PHARMACEUTICALS INC.Inventors: Lars Jacob Stray Knutsen, Judi Lois Knutsen
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Publication number: 20160317554Abstract: The present invention provides for novel combinations comprising an antihistamine with selected pharmaceutical and nutraceutical agents which alleviate some of the symptoms experienced by menopausal women, optionally combined further with a range of indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin. These mixtures may be enriched further with pharmaceutically acceptable calcium and magnesium salts as well as selected B vitamins. These combinations have utility in providing a medicament for improving health in mammals, especially for the improvement of menopausal symptoms as welt as sleep in women.Type: ApplicationFiled: December 13, 2014Publication date: November 3, 2016Applicant: Requis Pharmaceuticals, Inc.Inventors: Lars Jacob Stray Knutsen, Judith Lois Knutsen, Mark A. Pimley
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Publication number: 20160008334Abstract: The present invention is directed to combinations of sedating antihistamines and at least one, and preferably two or more dietary supplements, which can be indole-based, such as tryptophan, 5-hydroxytryptophan, serotonin, N-acetyl-5-hydroxytryptamine and melatonin, and to their use for treating and thereby improving the health and quality of life of those suffering from sleep-related respiratory disorders, characterized by abnormal breathing during sleep. These include snoring, sleep disordered breathing, sleep apneas, upper airway resistance syndrome, obstructive sleep apnea, central sleep apnea and obesity hypoventilation syndrome and associated ailments.Type: ApplicationFiled: March 5, 2014Publication date: January 14, 2016Applicant: REQUIS PHARMACEUTICALS INC.Inventors: Lars Jacob Stray Knutsen, James M. Hand
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Publication number: 20150125548Abstract: The present invention is directed to nutritional and nutraceutical compositions which comprise novel mixtures of two or more indole-based dietary supplements such as L-tryptophan and melatonin, together with selected minerals and vitamins that stimulate tryptophan metabolism in the direction of serotonin and melatonin, and to their use in a preferred embodiment of the invention in a readily ingested beverage form, optionally combined with a range of other natural ingredients designed to improve the health and state of mind of human subjects. Alternative dosage forms, such as tablets for oral dosing, and dosage forms for buccal and sublingual administration, including thin films, are also incorporated in the present invention. Health improvements include the treatment of disorders of circadian rhythm, such as shift work disorder and jet lag, the induction of relaxation and a restful frame of mind, as well as providing restorative sleep function.Type: ApplicationFiled: November 13, 2012Publication date: May 7, 2015Applicant: Requis Pharmaceuticals Inc.Inventors: Lars Jacob Stray Knutsen, Judi Lois Knutsen
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Publication number: 20140199417Abstract: The present invention provides combinations comprising a sedating antihistamine and selected indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin, along with pharmaceutically acceptable calcium and magnesium salts and selected B vitamins. These combinations are useful in providing a medicament for improving sleep in mammals, especially humans.Type: ApplicationFiled: June 8, 2012Publication date: July 17, 2014Applicant: Requis Pharmaceuticals Inc.Inventors: Lars Jacob Stray Knutsen, Judi Lois Knutsen