Abstract: The invention relates to a method for the diagnosis of glaucoma based on the composition of autoantibodies against ocular antigens in body fluids of individuals. The method is characterized in that in a first step, autoantibodies against retinal and/or optic nerve head antigens are detected and measured in body fluids of an individual, and, in a second step, the auto-antibody pattern is correlated with corresponding patterns of healthy individuals and glaucoma patients. The invention further relates to a method for assessing an individual's risk for developing glaucoma, and to kits for use in the method of the invention.