Patents Assigned to Research and Development Institute, Inc.
  • Patent number: 6680860
    Abstract: Techniques for continuously programming a coherent transient spatial-spectral optical signal processor involve the repeated application of two or more spatially distinct optical programming pulses to a non-persistent hole-burning material to write an accumulated, spatial-spectral population grating with low intensity optical pulses as compared to single shot programming. An optical data stream is introduced on a processing beam, resulting in a processor output signal spatially distinct from all the processing pulses. Programming and processing take place simultaneously, asynchronously and continuously. For accumulated gratings, the frequency stability of the optical source is an important consideration.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: January 20, 2004
    Assignee: Research and Development Institute Inc.
    Inventors: Kristian Merkel, William Babbitt
  • Patent number: 6654394
    Abstract: Techniques for stabilizing a laser at a selectable frequency include splitting an output beam from an electrically adjustable laser into a first beam and a second beam. The second beam is transmitted through a modulator. Then the second beam is transmitted through a transient spectral hole burning material onto a detector. The laser is electronically adjusted in response to a detector output from the detector which senses the changes in the modulated second beam after it passes through the transient spectral hole burning material.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: November 25, 2003
    Assignee: The Research and Development Institute, Inc.
    Inventors: Peter B. Sellin, Nicholas M. Strickland, John L. Carlsten, Rufus L. Cone
  • Publication number: 20030072775
    Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.
    Type: Application
    Filed: February 14, 2002
    Publication date: April 17, 2003
    Applicant: The Research and Development Institute Inc.
    Inventors: Jim E. Cutler, Yongmoon Han, Pati M. Glee, Bruce L. Granger
  • Patent number: 6516014
    Abstract: Techniques for stabilizing a laser (110) at a selectable frequency include splitting an output beam from an electrically adjustable laser into a first beam (369) and a second beam (361). The second beam is transmitted through a modulator (112). Then the second beam is transmitted through a spectral hole burning material (310) onto a detector (120). The laser is electronically adjusted in response to a detector output from the detector which senses the changes in the modulated second beam after it passes through the spectral hole burning material.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: February 4, 2003
    Assignee: The Research and Development Institute, Inc.
    Inventors: Peter B. Sellin, Nicholas M. Strickland, John L. Carlsten, Rufus L. Cone
  • Patent number: 6407831
    Abstract: A method for optimizing the interaction of a resonant material having generalized crystal symmetry with a beam or beams of radiation. The invention includes determining a special direction relative to the axes of crystal symmetry of the material and polarizing the interaction radiation beam along this direction. The polarized radiation beam is propagated through the material perpendicular to this special direction. The method and system are used in any application which involves the coherent interaction of optical radiation beams or fields with resonant ion-doped or molecular crystals of various types. Coherent interaction of optical radiation beams or fields with resonant ion-doped or molecular crystals of various types includes the phenomena of optical coherent transients, spectral hole burning, and spatial-spectral holography (also called time and space domain holography) and provides the basis for optical-electronic devices. Such applications include computer and communications networks.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: June 18, 2002
    Assignee: Research and Development Institute, Inc.
    Inventors: Rufus L. Cone, Guanrring Wang, Yongchen Sun, Randy W. Equall
  • Patent number: 6403090
    Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.
    Type: Grant
    Filed: June 17, 1999
    Date of Patent: June 11, 2002
    Assignee: The Research and Development Institute Inc.
    Inventors: Jim E. Cutler, Yongmoon Han
  • Publication number: 20020054886
    Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans. Monoclonal antibodies for use in passive immunization against candidal infections.
    Type: Application
    Filed: December 11, 2000
    Publication date: May 9, 2002
    Applicant: The Research and Development Institute Inc.
    Inventors: Jim E. Cutler, Yongmoon Han
  • Patent number: 6309642
    Abstract: A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: October 30, 2001
    Assignee: The Research and Development Institute, Inc.
    Inventors: Jim E. Cutler, Pati M. Glee
  • Patent number: 6180389
    Abstract: A virion-constrained nanoparticle of the invention comprises a shell of a virion coat protein(s) that encapsulates a core non-viral material, which is organic, inorganic or organometallic in nature. A particularly preferred virion coat is that of cowpea chlorotic mottle virus (CCMV). Encapsulation of a desired particle is effected by adjusting reaction conditions, e.g., by lowering the pH of a solution containing the virion protein and the non-viral substance. Processes for producing the virion-constrained nanoparticles of the invention are also described.
    Type: Grant
    Filed: January 3, 1997
    Date of Patent: January 30, 2001
    Assignee: The Research and Development Institute, Inc.
    Inventors: Trevor Douglas, Mark J. Young
  • Patent number: 6151337
    Abstract: The present invention provides a means to generate a Raman-shifted output from a pump laser source. Multiple embodiments all provide a manner of producing an off-resonant, continuous wave, Raman laser by using a pump laser source having a low power. This is accomplished by using a Raman medium within a cavity having a high finesse.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: November 21, 2000
    Assignee: The Research and Development Institute, Inc.
    Inventors: John Carlsten, Kevin Repasky, Jason Brasseur
  • Patent number: 5981264
    Abstract: An isolated substantially pure pseudomonas culture, exemplified by pseudomonas syringae MSU 16H (ATCC No. 67028), produces the substantially pure peptide pseudomycin which has broad spectrum anti-fungal characteristics.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: November 9, 1999
    Assignee: The Research and Development Institute, Inc. at Montana State University
    Inventors: Gary A. Strobel, Leslie A. Harrison, David B. Teplow
  • Patent number: 5885791
    Abstract: An assay and test kit for testing and quantifying fungal inhibition by an antifungal agent. In the assay, inhibition is measured by a reduction in substrate uptake (such as glucose) as compared to uninhibited controls. A minimum inhibitory concentration value for each antifungal agent is obtained from the assay.
    Type: Grant
    Filed: November 16, 1995
    Date of Patent: March 23, 1999
    Assignees: The Research and Development Institute, Inc., The University of Virginia Patent Foundation
    Inventors: Jim E. Cutler, Marcia H. Riesselman, Kevin C. Hazen
  • Patent number: 5837685
    Abstract: Peptide antimycotics, termed pseudomycins, display broad spectrum antibiotic activity, and in particular are highly effective, non-toxic antibiotics against fungal pathogens of human and animal disease. The peptide antimycotics (pseudomycins) may be used in the treatment of the fungal pathogen Candida albicans. Also disclosed is a method of purification and isolation, including characterization, of the pseudomycins.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: November 17, 1998
    Assignee: Research and Development Institute Inc. at Montana State University
    Inventors: Gary A. Strobel, Leslie A. Harrison, David B. Teplow
  • Patent number: 5756095
    Abstract: The present invention involves monoclonal antibodies which recognize a common determinant found on separate and distinct adhesion molecules. The monoclonal antibodies are used for blocking cellular adhesion. Monoclonal antibodies are also described that are capable of binding to a common determinant expressed on separate and distinct selectins and in particular antibodies that bind to both E-selectin (also known as ELAM-1) and L-selectin (also known as LAM-I, LECAM-1, Leu-8, TQ-1, gp 90 MEL-14 and peripheral lymph node homing receptor). The monoclonal antibodies are useful in the diagnosis, treatment and prevention of diseases associated with inflammation. The monoclonal antibodies are used for detecting cells bearing selectins. Cell lines capable of producing the above described antibodies are also described.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 26, 1998
    Assignee: The Research and Development Institute, Inc.
    Inventor: Mark A. Jutila
  • Patent number: 5591435
    Abstract: Preparations from aromatic plants that are insecticidal or are insect behaviorally active, are used to control the development of insect populations. Leaves are milled or out drying to a small average particle size. Extracts and vapors may also be used. The resultant preparation, when contacted dry commodities or structures such as books or carpets, grain bins feed/flour mills, equipment, greenhouse or ornamental plants infested storage insects or insect infested perishable produce after harvest will reduce the insect population. In addition, soil may be fumigated the extracts.
    Type: Grant
    Filed: April 25, 1994
    Date of Patent: January 7, 1997
    Assignee: The Research and Development Institute, Inc.
    Inventors: Florence Vaccarello-Dunkel, David K. Weaver, Theodore W. Weaver, III
  • Patent number: 5578309
    Abstract: A composition, pharamaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannoprotein which contains adhesins from C. albicans.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 26, 1996
    Assignee: The Research and Development Institute, Inc.
    Inventors: Jim E. Cutler, Yongmoon Han
  • Patent number: 5576298
    Abstract: Peptide antimycotics, termed pseudomycins, display broad spectrum antibiotic activity, and in particular are highly effective, non-toxic antibiotics against fungal pathogens of human and animal disease. The peptide antimycotics (pseudomycins) may be used in the treatment of the fungal pathogen Candida albicans. Also disclosed is a method of purification and isolation, including characterization, of the pseudomycins.
    Type: Grant
    Filed: September 15, 1994
    Date of Patent: November 19, 1996
    Assignee: Research and Development Institute, Inc. at Montana State University
    Inventors: Gary A. Strobel, Leslie A. Harrison, David B. Teplow
  • Patent number: 5570279
    Abstract: PWM converters provide buck, boost, buck-boost, flyback, and Cuk configurons for three phase AC-AC power control. In an AC-DC embodiment, only a single power conversion circuit is used in a configuration including a pair of series connected gate turn off devices which are oppositely poled and oppositely timed, are connected directly to an AC input source, and provide an output to a high frequency isolating transformer. The transformer provides an output to a rectifier, which thus provides the DC output.
    Type: Grant
    Filed: September 21, 1994
    Date of Patent: October 29, 1996
    Assignee: The Research and Development Institute, Inc. at Montana State University
    Inventor: Giri Venkataramanan
  • Patent number: 5538890
    Abstract: A broad spectrum biological herbicide comprises a mammal-sparing bioherbicide fungal mutant, e.g., a S. sclerotiorum mutant, of limited survival time and geographical dissemination characteristics under standard agricultural conditions. The invention also relates to a method of obtaining herbicides of the invention comprising obtaining viable wild type bioherbicide fungal spores, subjecting these to UV light to reduce the number of viable fungi to less than 5% the initial number of spores, selecting mutants which differ from the wild type in at least one characteristic such as altered phenotype or morphology, and further selecting a mammal-sparing bioherbicide fungal mutant of reduced survival time and geographical dissemination characteristics under agricultural conditions when compared with the wild type. The invention also relates to a method of using the broad spectrum biological herbicide to reduce the number of weeds in an area.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: July 23, 1996
    Assignee: Research and Development Institute, Inc. at Montana State University
    Inventors: David C. Sands, Roger V. Miller, Eugene Ford, Gregory Kennett
  • Patent number: 5343155
    Abstract: A system for detecting and locating faults on a power system includes the e of fault detection and transmitting devices on each pole of the system. The fault detection apparatus includes detecting coils mounted on the static line on either side of each pole, and a third detecting coil positioned so as to detect an orthogonal magnetic flux due to a phase-to-phase fault. A microprocessor on each pole analyzes the type of fault from the output of the three coils, and transmits the identification of the pole and pertinent fault data, when appropriate, to a repeater system. Thus, fault information from an entire power system can be fed through the repeater system into a central location.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: August 30, 1994
    Assignee: The Research and Development Institute, Inc. at Montana State University
    Inventors: Murari L. Kejariwal, Baldev Thapar, Victor Gerez, Daniel March