Patents Assigned to RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH
  • Patent number: 11118954
    Abstract: A system and a method for a constant micro dosing of powder material include a control device, a cylinder with a first opening and a piston movably arranged inside the cylinder and controllable by the control device. The piston is movable in the direction to or away from the first opening along a piston stroke direction. The cylinder stores the powder material between the piston and the first opening. The piston pushes the powder material through the first opening by moving along the piston stroke direction. Further the system and the method include a removing device for removing the powder material which is pushed out of the first opening of the cylinder. The control device controls the piston and the removing device in a synchronized manner such that a predetermined amount of powder material pushed through the first opening is removable by the removing device.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: September 14, 2021
    Assignee: Research Center Pharmaceutical Engineering GmbH
    Inventors: Johannes Khinast, Eyke Slama, Sara Fathollahi, Thomas Klein, Maximilian Besenhard
  • Patent number: 11119041
    Abstract: A method of monitoring a property of a dissolution of an at least partially solid dosage form during a dissolution process is disclosed. The method includes at least partially dissolving the dosage form, and during the dissolution of the dosage form, simultaneously monitoring the property of the dissolution of the dosage form in progress by low coherence interferometry.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: September 14, 2021
    Assignee: Research Center Pharmaceutical Engineering GmbH
    Inventors: Massimo Bresciani, Daniel Markl, Annalisa Mercuri, Johannes Khinast, Thomas Klein
  • Publication number: 20190391076
    Abstract: A method of monitoring a property of a dissolution of an at least partially solid dosage form during a dissolution process is disclosed. The method includes at least partially dissolving the dosage form, and during the dissolution of the dosage form, simultaneously monitoring the property of the dissolution of the dosage form in progress by low coherence interferometry.
    Type: Application
    Filed: March 21, 2017
    Publication date: December 26, 2019
    Applicant: Research Center Pharmaceutical Engineering GmbH
    Inventors: Massimo BRESCIANI, Daniel MARKL, Annalisa MERCURI, Johannes KHINAST, Thomas KLEIN
  • Patent number: 9649256
    Abstract: A method and a device for monitoring a property of a coating of a solid dosage form during a coating process forming the coating of the solid dosage form are provided. The device comprises a coating apparatus configured for forming the coating on the solid dosage form, and a monitoring apparatus configured for monitoring the property of the coating of the solid dosage form in process, wherein at least a part of the monitoring apparatus is located so as to have insight in an interior of the coating apparatus, the interior accommodating the solid dosage form to be coated and a precursor for forming the coating, and wherein the monitoring apparatus is configured for monitoring the property of the coating of the solid dosage form simultaneously with and during a coating process using low coherence interferometry.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: May 16, 2017
    Assignees: Research Center Pharmaceutical Engineering GmbH, Research Center for Non Destructive Testing GmbH
    Inventors: Daniel Markl, Guenther Hannesschlaeger, Michael Leitner, Stephan Sacher, Daniel Koller, Johannes Khinast
  • Publication number: 20140322429
    Abstract: A method and a device for monitoring a property of a coating of a solid dosage form during a coating process forming the coating of the solid dosage form are provided. The device comprises a coating apparatus configured for forming the coating on the solid dosage form, and a monitoring apparatus configured for monitoring the property of the coating of the solid dosage form in process, wherein at least a part of the monitoring apparatus is located so as to have insight in an interior of the coating apparatus, the interior accommodating the solid dosage form to be coated and a precursor for forming the coating, and wherein the monitoring apparatus is configured for monitoring the property of the coating of the solid dosage form simultaneously with and during a coating process using low coherence interferometry.
    Type: Application
    Filed: April 29, 2014
    Publication date: October 30, 2014
    Applicants: Research Center Pharmaceutical Engineering GmbH, Research Center for Non Destructive Testing GmbH
    Inventors: Daniel Markl, Guenther Hannesschlaeger, Michael Leitner, Stephan Sacher, Daniel Koller, Johannes Khinast
  • Publication number: 20110156315
    Abstract: An apparatus for manufacturing a medication comprising an ejector unit adapted for ejecting a predefined amount of a drug having a liquid component to a solid carrier substrate. The ejector unit comprises a capillary and a tubular piezoelectric actuator surrounding at least a part of the capillary. The apparatus further comprises a control unit adapted for applying an electric signal to the piezoelectric actuator which, in response to the electric signal, is adapted to generate a compressional wave in the capillary for ejecting the predefined amount of the drug via an orifice of the capillary. Moreover, a method of manufacturing a medication is provided, the method comprising ejecting a predefined amount of a drug having a liquid component to a solid carrier substrate. Furthermore, a medication is provided comprising a solid carrier substrate, and a predefined amount of a drug ejected with a liquid component to the solid carrier substrate by an ejector unit.
    Type: Application
    Filed: July 30, 2009
    Publication date: June 30, 2011
    Applicant: RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH
    Inventors: Johannes Khinast, Günter Brenn, Andreas Zimmer, Rudolf Eichinger, Wolfgang Bauer