Patents Assigned to Research Corporation Tech., Inc.
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Patent number: 6162925Abstract: The present invention is directed to anti-bacterial and anti-tumor agents and the synthesis thereof.Type: GrantFiled: November 18, 1999Date of Patent: December 19, 2000Assignee: Research Corporation Tech., Inc.Inventors: Robert M. Williams, Chenguang Yuan
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Patent number: 6057116Abstract: Methods and compositions are provided for detecting antigens having a specific epitope associated with melanoma and prostatic carcinoma. The epitope is present in melanoma cells and prostatic cancer cells but is essentially absent from melanocytes and normal prostatic tissue. The antibody can be used in diagnostic methods for histochemical detection of human melanoma and prostate carcinoma, of various progression stages and in treatment of melanoma and prostate carcinoma.Type: GrantFiled: June 2, 1997Date of Patent: May 2, 2000Assignee: Research Corporation Tech., Inc.Inventor: Juergen R. Vielkind
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Patent number: 6048899Abstract: The present invention is directed to N-benzyl-2-amino-3-methoxypropionamide and stereoisomers the use thereof anti-convulsant and an intermediate in the preparation of other anti-convulsants.Type: GrantFiled: June 29, 1998Date of Patent: April 11, 2000Assignee: Research Corporation Tech., Inc.Inventors: Harold Kohn, Shridhar V. Andurkar
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Patent number: 5880158Abstract: The present invention is directed to a compound of the following formula: ##STR1## pharmaceutical compositions containing the same and the use thereof as an anticonvulsant.Type: GrantFiled: September 26, 1997Date of Patent: March 9, 1999Assignee: Research Corporation Tech., Inc.Inventor: Harold Kohn
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Patent number: 5767103Abstract: The present invention describes a method of sequestering nitric oxide from the bloodstream, endothelium or tissues of mammals by administering a cobalamin to such mammals. A method of treating diseases characterized by elevated nitric oxide levels in the bloodstream, endothelium or tissues is further provided. In particular, a method of treating sepsis by administering a therapeutic dose of hydroxocobalamin is described by the present invention. A method of alleviating systemic hypotension in a septic patient is further described by this invention. A pharmaceutical composition comprising a cobalamin in a concentration ranging from 0.5 to 50 mg composition/Kg body weight for mammals and is also provided.Type: GrantFiled: April 19, 1995Date of Patent: June 16, 1998Assignee: Research Corporation Tech., Inc.Inventors: Stanley S. Greenberg, Jianming Xie, Mark J. S. Miller, Judith Zatarian-Kuebel
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Patent number: 5698675Abstract: This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence of an effective amount of a compound having the formula: ##STR1## and N-oxides thereof and salts thereof.Type: GrantFiled: June 6, 1995Date of Patent: December 16, 1997Assignee: Research Corporation Tech., Inc.Inventor: Louis A. Carpino
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Patent number: 5656621Type: GrantFiled: February 15, 1994Date of Patent: August 12, 1997Assignee: Research Corporation Tech., Inc.Inventors: Arthur G. Schwartz, Marvin Louis Lewbart
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Patent number: 5616605Abstract: This invention is directed to a collagenase inhibitor of the formula: ##STR1##Type: GrantFiled: August 8, 1994Date of Patent: April 1, 1997Assignee: Research Corporation Tech., Inc.Inventors: Robert D. Gray, Arno F. Spatola, Krzysztof Darlak
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Patent number: 5589725Abstract: Monolithic, internally asymmetrically stress biased electrically active ceramic devices and a method for making same is disclosed. The first step in the method of the present invention is to fabricate a ceramic element having first and second opposing surfaces. Next, only the first surface is chemically reduced by heat treatment in a reducing atmosphere. This produces a concave shaped, internally asymmetrically stress biased ceramic element and an electrically conducting, chemically reduced layer on the first surface which serves as one of the electrodes of the device. Another electrode can be deposited on the second surface to complete the device. In another embodiment of the present invention two dome shaped ceramic devices can be placed together to form a completed clamshell structure or an accordion type structure. In a further embodiment, the clamshell or accordion type structures can be placed on top of one another.Type: GrantFiled: May 5, 1995Date of Patent: December 31, 1996Assignee: Research Corporation Tech., Inc.Inventor: Gene H. Haertling
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Patent number: 5562925Abstract: Malignant tumors in animals are treated by parenterally administering to an affected animal a solution containing a complex compound of platinum in an amount effective to cause regression of the tumor.Type: GrantFiled: June 2, 1994Date of Patent: October 8, 1996Assignee: Research Corporation Tech. Inc.Inventors: Barnett Rosenberg, Loretta Vancamp, Thomas Krigas
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Patent number: 5157020Abstract: Disclosed herein is a synthetic senescent cell antigen comprised of purified peptides immunoreactive with antibodies to the naturally occurring antigen. Preferably, the synthetic senescent cell antigen comprises two peptides with the amino acid sequences SKLIKIFQDHPLQKTYN and LFKPPKYHPDVPYVKR, respectively. The antigen and peptides may be used in compositions, diagnostic kits, and methods for detecting or measuring antibodies to senescent cell antigen, studying cellular aging and autoimmune mechanisms, separating anions from a gas or liquid, or treating certain diseases.Type: GrantFiled: May 24, 1990Date of Patent: October 20, 1992Assignee: Research Corporation Tech., Inc.Inventors: Marguerite M. B. Kay, John J. Marchalonis