Abstract: This invention relates to lactobacillus compositions and methods of employing said compositions for treating or preventing urinary tract infections. More particularly, this invention relates to the ability of certain strains of lactobacilli to adhere to uroepithelial or vaginal epithelial cells and to exhibit inhibitory activity against the growth of pathogenic bacteria.

Abstract: The present invention is directed to compounds of the formula. ##STR1## useful as anti-cancer, anti-obesity, anti-hyperglycemic, anti-autoimmune and anti-hypercholesterolemic agent.

Abstract: Polymers which form ultrathin, chemically adherent, anisotropic films on substrate surfaces impart useful properties to the surface. The polymers can be functionalized with any of a wide array of side chains and groups to impart properties and/or uses to the substrate.

Abstract: A method of treating primary and recurrent atheromatous plaque development is provided. The method involves administering a therapeutically effective amount of SERP-1, admixed in a pharmaceutically acceptable carrier to the intimal or lumenal layer of arterial walls. Biologically active SERP-1 analogs are also provided.

Abstract: Polymers which form ultrathin, chemically adherent, anisotropic films on substrate surfaces impart useful properties to the surface. The polymers can be functionalized with any of a wide array of side chains and groups to impart properties and/or uses to the substrate.

Abstract: The present invention relates to compounds of the formula:R.sub.1 SCH(R.sub.2)CH(R.sub.3)CO-AA.sub.1 ?AA.sub.2 !.sub.m ?AA.sub.3 !.sub.n --X orHSCH.sub.2 ?CH.sub.2 CH(CH.sub.3).sub.2 !CO--Nal--NH.sub.2wherein Nal is L-3-(2-naphthyl)alanine;m is the integer 0 or 1; n is an integer from 0-2;AA.sub.1 is a non-polar hydrophobic aromatic amino acid;AA.sub.2 is alanine, glycine, leucine, isoleucine or phenylalanine;AA.sub.3 is one of the twenty naturally occurring amino acids, preferably glutamine or arginine;R.sub.1 is hydrogen, alkyl having from 1-10 carbon atoms, alkanoyl having from 2-10 carbon atoms, or aroyl having from 7-10 carbon atoms;R.sub.2 is hydrogen or alkyl having from 1-6 carbon atoms;R.sub.3 is hydrogen, alkyl having from 2-10 carbon atoms, cycloalkyl having from 3-6 carbon atoms, aryl or arylalkyl, wherein aryl moieties have from 6-10 carbon atoms;X is NH.sub.2, OH, OCH.sub.3 or OCH.sub.2 CH.sub.3 ;and salts thereof.

Abstract: The present invention provides single-stranded circular oligonucleotides each with at least one parallel binding (P) domain and/or at least one corresponding anti-parallel binding (AP) domain separated from each other by loop domains. When more than one P or AP domain is included in a circular oligonucleotide of the present invention, the additional P or AP domains can constitute loop domains for a pair of corresponding P and AP domains, and vice versa. The present invention further provides single-stranded circular oligonucleotides with at least one Hoogsten antiparallel (HAP) domain. Each P, AP and HAP domain has sufficient complementarity to bind to one strand of a defined nucleic acid target wherein the P domain binds in a parallel manner to the target and the HAP or AP domain binds in an anti-parallel manner to the target. Moreover, the present single-stranded circular oligonucleotides can bind to both single-stranded and double-stranded target nucleic acids.

Abstract: Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of .beta.-lactamases and are therefore useful in the treatment of penicillin resistant infections.

Abstract: The invention relates to a chiral selector useful in separating underivatized enantiomers of nonsteroidal anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such separation utilizing the chiral selector, which is also useful in achieving the enantiomeric separation of amines, alcohol derivatives, epoxides and sulfoxides. The invention is also directed to an apparatus which comprises the chiral selectors.

Abstract: The present invention provides stem-loop and circular oligonucleotides each with at least one Watson-Crick binding (WC) domain and at least one corresponding Hoogsteen binding (H) domain separated from each other by linker domains. Each WC domain has sufficient complementarity to bind to one strand of a defined nucleic acid target by Watson-Crick base pairing in an anti-parallel orientation. Each corresponding H domain is capable of binding to the WC domain by Hoogsteen base pairing in an anti-parallel manner. The present invention also provides methods of making and using these oligonucleotides as well as kits and pharmaceutical compositions containing these oligonucleotides.

Abstract: A process for the enhanced production of antigenic particles consisting essentially of hepatitis B S protein and preS.sub.2 protein. Also disclosed are novel DNA molecules and hosts transformed with these molecules.

Abstract: The present invention provides human interleukin-8 (IL-8) analogs that are modified in the Glu4 Leu5 Arg6 region, and have a core structure corresponding to the IL-8 (7-51) sequence are provided. These neutrophil binding analogs display altered IL-8 activities that can be exploited for therapeutic and other purposes. Such antagonists include those in which, for example, the Leu5 and/or Arg6 residues are replaced, and in which the Glu4 and/or Leu5 residues are deleted. Also provided are biologically active human interleukin-8 (IL-8) analogs comprising a core sequence that includes IL-8 (1-51), IL-8 (3-51) or IL-8 (4-51). The invention also provides pharmaceutical compositions containing the aforementioned analogs.

Abstract: Two novel linear DNA plasmids are described. Also, novel fragments of the plasmids containing the autonomous replication sequence (ARS), and thus capable of self-maintenance as extra chromosomal elements are provided. These novel DNA sequences of the present invention are useful in a vector for self-maintenance in Pichia pastoris and are also useful as plasmid vectors which can be shuttled between yeast and bacteria.

Abstract: Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention, the catalyst is a salen derivative which has the following general structure: ##STR1## In accordance with another aspect of the present invention is a method of, producing an epoxychroman using a chiral catalyst. In accordance with this method, a chromene derivative, an oxygen atom source, and a chiral catalyst are reacted under such conditions and for such time as is needed to epoxidize said chromene derivative. In accordance with yet another aspect of this invention is a method of enantioselectively epoxidizing a cis-cinnamate derivative to make taxol or an analog thereof. In accordance with another aspect a method of disproportionation of hydrogen peroxide using the catalysts of the present invention is disclosed.

Abstract: Fabry disease results from an X-linked deficiency in the enzyme .alpha.-galactosidase A. The present invention is directed to recombinant human .alpha.-galactosidase A and provides baculovirus expression vectors and recombinant virus that provide stable expression of extracellular and intracellular levels of this enzyme in an insect cell culture. The recombinant-derived enzyme can be used in enzyme replacement therapy to treat Fabry patients. Composition useful in therapeutic administration of .alpha.-galactosidase A are also provided.

Abstract: The present invention relates to compounds of the formula ##STR1##

Abstract: A process for the enhanced production of antigenic particles consisting essentially of hepatitis B S protein and preS.sub.2 protein. Also disclosed are novel DNA molecules and hosts transformed with these molecules.

Abstract: Protein tyrosine kinase inhibitors are provided of formula (I): ##STR1## wherein R.sup.2 is H, OH, halo or O(C.sub.1 -C.sub.4)alkyl; R.sup.2 is OH, halo or O(C.sub.1 -C.sub.4)alkyl; R.sup.1 is ##STR2## wherein R.sup.4 is H, OH, halo, CH.sub.2 OH, C(O)CH.sub.3, C(O)N(R).sub.2 wherein each R is H or (C.sub.1 -C.sub.4)alkyl; or C(O)R wherein R.sup.6 is OH or O(C.sub.1 -C.sub.4)alkyl; and R.sup.5 is OH, CH.sub.2 OH, C(O)CH.sub.3, C(O)N(R).sub.2 or C(O)R.sup.6 ; or a pharmaceutically acceptable salt thereof, which inhibit the pathological proliferation or growth of mammalian cells, such as cancer cells.

Abstract: The present invention relates to bis-imidazolyl compounds of the formula: ##STR1## and polymers having the above-identified bis-imidazolyl compounds as a polymerizable unit. The present invention further relates to a method for scavenging trace quantities of metal ions from various effluents sources using the polymers of the instant invention. The instant invention also is directed to the use of the above-identified polymers as corrosion inhibiting agents and as a film for use in gel electrophoresis.