Patents Assigned to Research Corporation Technologies
  • Patent number: 5637739
    Abstract: Methods of using chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed. In accordance with one aspect of the invention, the catalyst used is a salen derivative which has the following general structure: ##STR1## In accordance with another aspect of the present invention is a method of producing an epoxychroman using a chiral catalyst. In accordance with this method, a chromene derivative, an oxygen atom source, and a chiral catalyst are reacted under such conditions and for such time as is needed to epoxidize said chromene derivative. In accordance with yet another aspect of this invention is a method of enantioselectively epoxidizing a cis-cinnamate derivative to make taxol or an analog thereof. In accordance with another aspect a method of disproportionation of hydrogen peroxide using the catalysts of the present invention is disclosed.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: June 10, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Eric N. Jacobsen, Wei Zhang, Li Deng
  • Patent number: 5635506
    Abstract: This invention relates to a compound useful for the treatment of tumors having the formula: ##STR1##
    Type: Grant
    Filed: November 18, 1993
    Date of Patent: June 3, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: David S. Alberts, Robert T. Dorr, William A. Remers, Salah M. Sami
  • Patent number: 5631374
    Abstract: The present invention is directed to derivatives of aroyl-2-quinoline-carboxaldehyde and their use in detection and quantification of minute amounts of primary amines.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: May 20, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Milos V. Novotny, Donald Wiesler, Jinping Liu, You-Zung Hsieh
  • Patent number: 5629306
    Abstract: Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of .beta.-lactamase enzymes.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: May 13, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: John D. Buynak, Brian Bachmann
  • Patent number: 5627048
    Abstract: The present invention is directed to use of Aedes aegypti densonucleosis virus (Aedes DNV or AeDNV) as a heterologous gene expression system. The invention described herein provides promoters from the Aedes aegypti genome such as the p.05, p7 and p61 promoters to generate expression vectors with cloning sites for insertion of heterologous genes. The invention further provides expression vectors comprising an AeDNV promoter operably linked to a heterologous gene and insect host cells comprising the vectors of the invention. Methods of producing recombinant proteins utilizing the vectors of the invention are also provided. The present invention further provides a kit containing the vectors of the invention for production of a recombinant protein.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: May 6, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Boris N. Afanasiev, Jonathan O. Carlson, Barry Beaty, David R. Higgins, Kelly J. Thibault
  • Patent number: 5616253
    Abstract: The present invention relates to various methods, such as an above-ground method and an in-ground method, of using a palladized iron bimetallic system for the dechlorination of chlorinated organic compounds from various effluents or contaminated soil containing the same. The use of palladized iron bimetallic system results in the dechlorination of the chlorinated organic compound into environmentally safe reaction products.
    Type: Grant
    Filed: March 25, 1996
    Date of Patent: April 1, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Quintus Fernando, Rosy Muftikian, Nic Korte
  • Patent number: 5611936
    Abstract: The present invention relates to various methods, such as an above-ground method and an in-ground method, of using a palladized iron bimetallic system for the dechlorination of chlorinated organic compounds from effluents containing the same. The use of palladized iron bimetallic system results in the dechlorination of the chlorinated organic compound into environmentally safe reaction products. The present invention also provides kits, devices, and other instruments that use the above-mentioned palladized iron bimetallic system for the dechlorination of chlorinated organic compounds.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: March 18, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Quintus Fernando, Rosy Muftikian, Nic Korte
  • Patent number: 5610413
    Abstract: Group II-VI compound semiconductor light emitting devices which include at least one II-VI quantum well region of a well layer disposed between first and second barrier layers is disclosed. The quantum well region is sandwiched between first and second cladding layers of a II-VI semiconductor material. The first cladding layer is formed on and lattice matched to the first barrier layer and to a substrate of a III-V compound semiconductor material. The second cladding layer is lattice matched to the second barrier layer. The quantum well layer comprises a II-VI compound semiconductor material having the formula A.sub.x B.sub.(1-x) C wherein A and B are two different elements from Group II and C is at least one element from Group VI. When the second cladding layer has a p-type conductivity, a graded bandgap ohmic contact according to the present invention can be utilized.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 11, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Yongping Fan, Jung Han, Arto V. Nurmikko, Robert L. Gunshor, Li He
  • Patent number: 5610196
    Abstract: A method to inhibit microbial growth is provided comprising topically administering to a mammal afflicted with a pathology associated with microbial growth, such as a dermatological condition, an effective amount of a linear (C.sub.12 -C.sub.22) 3-alken-2-one or 3,.omega.-alkadien-2-one.
    Type: Grant
    Filed: December 11, 1995
    Date of Patent: March 11, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventor: William F. Wood
  • Patent number: 5605994
    Abstract: The present invention relates to bis-imidazolyl compounds of the formula: ##STR1## and polymers having the above-identified bis-imidazolyl compounds as a polymerizable unit. The present invention further relates to a method for scavenging trace quantities of metal ions from various effluents sources using the polymers of the instant invention. The instant invention also is directed to the use of the above-identified polymers as corrosion inhibiting agents and as a film for use in gel electrophoresis.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 25, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: J. Thomas Ippoliti, Gary A. Mabbott, Jeremy Hans, Michelle Stohlmeyer
  • Patent number: 5604262
    Abstract: A method to inhibit microbial growth is provided comprising topically administering to a mammal afflicted with a pathology associated with microbial growth, such as a dermatological condition, an effective amount of a linear (C.sub.12 -C.sub.22) 3-alken-2-one or 3,.omega.-alkadien-2-one.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: February 18, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventor: William F. Wood
  • Patent number: 5602313
    Abstract: A pink-flowered soybean plant which possesses large seeds and high protein seed content, without a concomitant decrease in yield. The pink-flowered soybean plant is easily distinguished from wild-type and domesticated cultivars by virtue of its unique flower color and appearance. The two commercially significant traits, large seed size and high protein seed content, cosegregate with the pink flower trait. Seed size and protein content of soybean cultivars are therefore efficiently and quickly increased by crossing with the pink-flowered plant, then selecting for pink-flowered progeny. Prior difficulties in tracking and monitoring increases in seed protein content are eliminated.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 11, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Cecil D. Nickell, Paul A. Stephens
  • Patent number: 5602007
    Abstract: This invention provides a DNA sequence coding for a mammalian granulocyte macrophage colony stimulating factor (GM-CSF), a method of obtaining same, vectors and hosts harboring same. The sequence is useful as a probe for identifying related sequences, selecting GM-CSF encoding mRNA from a mixture of mRNAs containing same, and a source of GM-CSF DNA for expression in an appropriate expression vector. The GM-CSF protein encoded by the sequence is useful for stimulating the production of granulocytes and macrophages from their respective progenitor cells.
    Type: Grant
    Filed: December 9, 1988
    Date of Patent: February 11, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Ashley R. Dunn, Nicholas M. Gough, Donald Metcalf
  • Patent number: 5599625
    Abstract: A protective monolayer is formed on e.g. silica gel and glass surfaces comprising a monolayer of silicon and oxygen atoms which is substituted with first and second hydrocarbyl substituents.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: February 4, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Mary J. Wirth, Hafeez O. Fatunmbi
  • Patent number: 5599899
    Abstract: A class of rigid rod and latter polymers having light emitting capability is provided. Included in this class of polymers are those having novel repeating structural units. These rigid rod and ladder polymers are employed in light emitting diodes.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: February 4, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Samson A. Jenekhe, John A. Osaheni
  • Patent number: 5597890
    Abstract: The present invention is directed to an exciplex formed from a .pi.-conjugated polymer and an electron donor or acceptor component. The present invention also relates to assemblies comprising said exciplex, their use in optoelectrical devices and method of enhancing optoelectrical properties of .pi.-conjugated polymers by forming said exciplex.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: January 28, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Samson A. Jenekhe
  • Patent number: 5595871
    Abstract: The present invention is directed to a rapid and sensitive method for detecting Mycoplasma hominis using M. hominis-specific probes, oligonucleotides or antibodies. In particular a target sequence can be amplified by in vitro nucleic acid amplification techniques, detected by nucleic acid hybridization using the subject probes and oligonucleotides or detected by immunoassay using M. hominis-specific antibodies. M. hominis-specific nucleic acids which do not recognize or hybridize to genomic nucleic acid of other Mycoplasma species are also provided.
    Type: Grant
    Filed: August 25, 1993
    Date of Patent: January 21, 1997
    Assignees: University of Scranton, Research Corporation Technologies, Inc.
    Inventors: Vito G. DelVecchio, Gary L. Gallia, Ferne K. McCleskey
  • Patent number: 5595562
    Abstract: A method of performing a gastrostomy by ischemia-induced tissue remodeling. To accomplish this, a small intragastric disk is magnetically coupled to a larger disk on the outside of the abdominal wall. The attractive magnetic force acting on the two disks occludes blood flow to the intervening tissue. The ensuing local ischemia results in infarction and resorption of that tissue. As the tissue is resorbed, the smaller intragastric disk is drawn toward the larger disk on the outside of the abdominal wall creating a stoma in its path and leaving the stomach adherent to the abdominal wall around the perimeter of the smaller disk.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: January 21, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Jonathan F. Grier
  • Patent number: 5593894
    Abstract: The present invention relates to the direct quantitative determination of cholesterol and involves the formation of a spectrophotometrically active product of cholesterol obtained by contacting cholesterol with an acyl compound and a perchlorate effective to form the spectrophotometrically active product.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 14, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Neil Purdie
  • Patent number: 5585575
    Abstract: An explosive detection screening system used for the detection of explosives and other controlled substances such as drugs or narcotics. The screening system detects the vapor and/or particulate emissions from the aforementioned substances and reports that they are present on an individual or object and the concentration of each substance detected. The screening system comprises a sampling chamber for the collection of the vapor and/or particulate emissions, a concentration and analyzing system for the purification of the collected vapor and/or particulate emissions and subsequent detailed chemical analysis of the emissions, and a control and data processing system for the control of the overall system.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 17, 1996
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Colin Corrigan, Lawrence Haley