Abstract: The present invention relates to heparanase-neutralizing monoclonal antibodies (m Abs), pharmaceutical composition comprising same, and use thereof for treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, diabetes and related complications. The present invention further provides combined therapies comprising the heparanase-neutralizing m Ab and an anti-cancer treatment such as chemotherapy or radiation, for treating a proliferative disease in a subject.

Abstract: Provided herein are methods for the diagnosis, assessment, and treatment of cancer. In some aspects, detection of intracellular or cytoplasmic PD-L1, or measuring the ratio of cytoplasmic to surface PD-L1, can be used to identify cancers that may respond to immunotherapies or a DDR inhibitor such as, e.g., a Chk1 inhibitor, a PARP inhibitor, an ATM inhibitor, or an ATR inhibitor.

Abstract: A Doppler radar sensor includes a radar and a bondwire interconnection. The bondwire interconnection is connected to a signal generator and an antenna of the radar and configured to transmit a radio frequency signal generated by the signal generator to the antenna and transmit a reflected signal received by the antenna to a demodulator of the radar. A metal strip, a first shunt bondwire and a second shunt bondwire of the bondwire interconnection can be used as a matching circuit of the antenna to decrease the transmission loss and increase the detection distance of the radar.

Abstract: There is provided an ultrasound device comprising: ultrasound transducer(s), memory storing code, hardware processor(s) coupled to the ultrasound transducer(s) and the memory for executing stored code comprising: activating the transducer(s) for simultaneously transmitting at least one line with a predefined focus width, and receiving an indication of a plurality of narrow-focused received lines, inputting the indication of the narrow-focused received lines into a convolutional neural network (CNN) trained on pairs of ultrasound imaging data capturing rapid motion of the certain tissue of sample patient(s), including a single-line ultrasound imaging data captured based on a single line in response to a transmitted single narrow-focused pulse, and a multiple-line ultrasound imaging data captured based on receiving narrow-focused lines in response to simultaneously transmitted at least one line, outputting adjusted narrow-focused received lines, and computing an adjusted ultrasound image according to the adjust

Abstract: A system for generating light, comprises a spectral light source, characterized by a spectral line shape described by a visibility function; and a multimode waveguide, characterized by an optical path difference distribution described by a standard deviation. The standard deviation typically matches, within a predetermined tolerance, a location of a zero point of the visibility function at which a contrast of the visibility function is less than 0.1.

Abstract: The present invention provides an implant which includes: (a) an autologous engineered tissue; and (b) a vasculature, wherein the engineered tissue is a porous scaffold embedded with endothelial cell, a fibroblast, a myoblast, a mesenchymal cell, an adipocyte, or any combination thereof, wherein the vasculature feeds the cells. Further, the invention provides a method for treating a subject afflicted with a large soft tissue defect by implanting the implant of the invention.

Abstract: Systems and methods are provided for moving replicas of a target data object between a plurality of storage nodes that store multiple replicated data objects, by setting new applications to a move mode, waiting for prior applications to exit before moving the target data object, determining that an indication of access to the target data object is done, and responsively copying the replicas of the target data object from first locations among the plurality of data storage nodes to second locations among the plurality of storage nodes.

Abstract: Exemplary embodiments of the present disclosure include systems and methods capable of imaging, manipulating, and analyzing tissue using light, including for example, coagulating and breaking the molecular bonds (e.g. cutting) tissue.

Abstract: A system comprising: at least one hardware processor; and a non-transitory computer-readable storage medium having stored thereon program instructions, the program instructions executable by the at least one hardware processor to: receive spectral data acquired from a plurality of fruits, wherein the spectral data is obtained within a specified range of wavelengths, at a training stage, train a machine learning model on a training set comprising: (i) the spectral data, and (ii) labels indicating, with respect to each of the fruits, a drop status within a specified time period subsequent to the acquiring, and at an inference stage, apply the machine learning model to target spectral data acquired from a target fruit, to predict the drop status of the target fruit within a specified time range subsequent to the acquiring.

Abstract: A sensing device that may include sensing elements that elements comprise a first sensing element, a second sensing element; wherein each sensing element comprises one or more piezoresistive materials; and a sensing circuit that is coupled to the sensing elements, wherein the sensing circuit is configured to sense a resistance of the first sensing element and of the second sensing element, and to determine, based on the resistance of the first sensing element and of the second sensing element, a first parameter of a cardiac waveform of a living being, wherein the cardiac waveform (a) is sensed by the first sensing element, and (ii) is not sensed by the second sensing element.

Abstract: Provided herein are chimeric polypeptides that may be used, e.g., for the diagnosis of or vaccination against Ehrlichia chaffeensis and/or Ehrlichia canis.

Abstract: There is provided a method of representing a three dimensional (3D) object using univariate curves, comprising: receiving an initial definition of a 3D object representation, calculate a covering set of univariate curves, the covering set comprising at least one non-planar univariate curve, wherein the covering set of univariate curves represent the volume of the 3D object within a tolerance requirement, and generating a representation of the 3D object based on the set of univariate curves, wherein the set of univariate curves represent the volume of the 3D object.

Abstract: A method comprising using one or more hardware processors for automatically receiving two or more data objects and two or more data storage addresses, wherein each data storage address directs to one of two or more non-transitory computer readable storage medium locations. The method comprises the action of computing two or more parameter values for each of the data objects. The method comprises the action of grouping the data objects based on the parameter values and two or more predefined rules, thereby producing two or more groups. The method comprises the action of assigning each of the groups to one of the data storage addresses based on the predefined rules. The method comprises the action of storing each of the objects of the groups at one of the non-transitory computer readable storage medium locations based on the assigning.

Abstract: A composite comprised of: (i) at least one inverse freezing material, and (ii) an additive in the form of at least one solid particle. Articles made of the composites, and uses of the composites or the articles incorporating same, particularly for reducing incoming shockwaves, are also disclosed.

Abstract: A modular robotic surgical system comprising: one or more tool-receiver units arranged as separate units, each tool-receiver unit operable to move a first elongate surgical tool received therein; a base comprising one or more motors, the base operable to move a second elongate surgical tool attached to the base or received therein, the base serving as a mounting for the one or more tool-receiver units; wherein each of the tool-receiver units is independently and interchangeably attachable to the base via a mechanical coupling interface which transfers one or more of: driving force for driving movement of the first elongate surgical tool received within the unit; electrical power supply to one or more components of the unit which drive movement of the first elongate surgical tool received within the unit; and data for controlling movement of the first elongate surgical tool received within the unit.

Abstract: A system for extracting water from the atmosphere is disclosed. The system has a vapor absorber vessel, an absorption cycle pump, a flash drum vapor desorber, a vapor condenser, an output conduit, and a heat exchanger. The vessel has an atmospheric air inlet and outlet ports, at least one liquid desiccant inlet port, at least two liquid desiccant outlet ports, and a surface on which the liquid desiccant flows between the at least one liquid desiccant inlet port and the at least two liquid desiccant outlet ports. The pump is adapted to circulate a first portion of the liquid desiccant from a first of the outlet ports to the at least one inlet port. The desorber is adapted to receive a second portion of the liquid desiccant from a second of the outlet ports, after passage through an expansion valve, the desorber incorporates a heat exchanger for supplying heat to liquid desiccant therein.

Abstract: Embodiments of the invention are directed to a method of separating and encapsulating an analyte on a microfluidic device in order to extract the analyte. A microfluidic device is provided having a main microchannel and a set of one or more auxiliary microchannels, each branching to the main microchannel at respective junctions therewith. A mixture is introduced as a single phase in the main microchannel in order to electrokinetically separate an analyte from the introduced mixture, and in order to confine the separated analyte in a microchannel portion of the main microchannel. The microchannel portion adjoins one of the junctions. One or more encapsulating volumes of an encapsulating phase are injected in the main microchannel via one or more of the auxiliary microchannels. The encapsulating phase is immiscible with said single phase. The encapsulated analyte is extracted from the main microchannel via one or more of the auxiliary microchannels.

Abstract: The present invention provides, in some embodiments, an isotachophoresis (ITP) apparatus, a kit comprising same and method of use thereof for the focusing analytes of interest from large sample volumes.

Abstract: Modified aminoglycoside compounds represented by Formula I as defined and described in the specification are provided. The modified aminoglycosides feature a diamine-containing functional moiety at one or more of positions 3?, 4? and 6?. Uses of the modified aminoglycosides as antimicrobial (e.g., antibacterial) agents, and in treating medical conditions associated with microorganisms, are also provided.

Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.