Abstract: Virion-constrained nanoparticles comprising a shell of virion coat protein(s) surrounding an organic, inorganic and/or organo-metallic non-viral nanoparticle and methods of making and using.
Type:
Grant
Filed:
December 12, 2000
Date of Patent:
January 10, 2006
Assignee:
The Research & Development Institute, Inc.
Abstract: Virion-constrained nanoparticles comprising a shell of virion coat protein(s) surrounding an organic, inorganic and/or organo-metallic non-viral nanoparticle and methods of making and using.
Type:
Application
Filed:
December 12, 2000
Publication date:
November 4, 2004
Applicant:
The Research & Development Institute, Inc.
Abstract: Autoinducer compounds which enhance gene expression in a wide variety of microorganisms, therapeutic compositions and therapeutic methods wherein gene expression within microorganisms is regulated are disclosed.
Type:
Grant
Filed:
March 13, 2002
Date of Patent:
June 29, 2004
Assignee:
The Research & Development Institute, Inc.
Abstract: The present invention pertains, in general, to the identification, isolation and use of Telomerase Reverse Transcriptase (TERT) genes and the proteins encoded by such genes. In particular, the present invention pertains to the identification, isolation and use of TERT genes and TERT proteins from several genetically diverse and economically important organisms, including two human pathogens, Candida albicans and Plasmodium falciparum and an agronomic crop species, Oryza sativa.
Type:
Grant
Filed:
October 13, 1999
Date of Patent:
April 1, 2003
Assignee:
Research & Development Institute, Inc.
Inventors:
David M. Long, Anneke M. Metz, Ruschelle A. Love
Abstract: This invention relates to new vaccines against microorganisms based on antigenically mimetic peptides. The invention also relates to methods of discovering such mimetic peptides by first screening peptide-display phage libraries with antibodies against the microbial carbohydrates(s) of interest to locate antigenically mimetic peptides. Vaccines against Group B Streptococcus, or Streptococcus Agalactiae, are preferably produced using this method.
Abstract: Autoinducer compounds which enhance gene expression in a wide variety of microorganisms, therapeutic compositions and therapeutic methods wherein gene expression within microorganisms is regulated are disclosed.
Type:
Grant
Filed:
June 18, 1998
Date of Patent:
January 8, 2002
Assignee:
The Research & Development Institute, Inc.
Abstract: A rapid method for the detection, identification and enumeration of specific respiring microorganisms. The method includes steps of a) passing a microbial sample through a collecting device to capture the cells; b) adding to the collecting device a fluorochrome dye specific for the detection of respiring cells and allowing the dye to incubate; c) treating the collecting device with a reactive fluorescent antibody which reacts with a target microorganism of interest present in said microbial sample; d) mounting the collecting device for examination by fluorescence microscopy in which a suitable light system is used to excite the fluorochrome dye and fluorescent antibody to fluoresce; and e) quantifying the respiring cells. Alternative embodiments include the use of immunomagnetic beads and other means of cell capture, and employing fluorescent oligonucleotide probes rather than fluorescent antibodies.
Type:
Grant
Filed:
May 19, 1997
Date of Patent:
October 13, 1998
Assignee:
The Research & Development Institute, Inc.
Abstract: The isotopes of boron, .sup.10 B and .sup.11 B, are separated by means of a gas-liquid chemical exchange reaction involving the isotopic equilibrium between gaseous BF.sub.3 and a liquid BF.sub.3 . donor molecular addition complex formed between BF.sub.3 gas and a donor chosen from the group consisting of: nitromethane, acetone, methyl isobutyl ketone, or diisobutyl ketone.