Patents Assigned to Research Development
  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20180028601
    Abstract: Provided are compositions and methods of targeting imaging or therapeutic agents to cancer sites using Fap2. Also provided are methods of treating cancer by inhibiting the complexing of Fusobacterium nucleatum Fap2 and Gal-GalNAc molecules expressed on cancer cells.
    Type: Application
    Filed: July 25, 2017
    Publication date: February 1, 2018
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Gilad Benjamin BACHRACH, Ofer MANDELBOIM, Jawad ABED
  • Pixel circuit
    Patent number: 9881968
    Abstract: A pixel arrangement includes a photodiode, a reset transistor configured to be controlled by a reset signal and coupled to a reset input voltage, a transfer gate transistor configured to transfer charge from the photodiode to a node, wherein the transfer gate transistor is controlled by a transfer gate voltage, and a source follower transistor controlled by the voltage on the node and coupled to a source follower voltage. A capacitor is coupled between the node and an input voltage. During a read operation the input voltage is increased to boost the voltage at the node. The increased input voltage may, for example, be one the reset input voltage, said source follower voltage, said transfer gate voltage and a boosting voltage.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: January 30, 2018
    Assignees: STMicoelectronics (Grenoble 2 ) SAS, STMicroelectronics (Research & Development) Limited
    Inventors: Graeme Storm, Christophe Mandier, Laurence Stark
  • SYSTEM AND METHOD FOR SINGLE CELL GENETIC ANALYSIS
    Publication number: 20180023128
    Abstract: Provided are methods and systems for parallel analysis of a single cell's nucleic acid.
    Type: Application
    Filed: February 4, 2016
    Publication date: January 25, 2018
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Itai YANAI, Uri SIVAN, Elad BROD, Tamar HASHIMSHONY, Anatoly SENDEROVICH
  • Motor unit contactless passive operation time counter
    Patent number: 9875582
    Abstract: An apparatus is provided that measures usage of a motor unit having a motor and a motor cable leading to the motor to provide operational power to the motor. The apparatus includes a housing that attaches to the motor cable such that the motor cable passes through an interior region of the housing. A sensor is situated in the interior region of the housing and is operable to sense current that flows in the motor cable. The apparatus has a counter that logs accumulated time of operation of the motor based on an amount of time that current is sensed by the sensor to be flowing in the motor cable.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: January 23, 2018
    Assignee: Liko Research & Development AB
    Inventors: Andreas Bolin, Karin Olsson, Göran Eriksson, Nicolas Thenault, Håkan Lindholm
  • Optical module and method
    Patent number: 9876973
    Abstract: An optical module for use in a device includes an array of pixels configured to capture image data and a memory. The memory is configured to store identification information associated with said optical module. The identification information enables retrieval of information for controlling said optical module from a source outside said device.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: January 23, 2018
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventor: Andy Price
  • Pro-angiogenic peptides and peptide conjugates
    Patent number: 9873724
    Abstract: Short bioactive sequences derived from the 2nd loop of the 7-transmembranal receptor of endothelial differentiation gene 3 (EDG3) useful in stimulation of angiogenesis, and peptide conjugates comprising a permeability enhancing moiety, are provided. Also provided are pharmaceutical compositions comprising the peptides and methods of use in conditions were insufficient blood-supply occurs, or which are associated with endothelia dysfunction such as peripheral vascular diseases, coronary artery diseases, cerebrovascular diseases, diabetes and delayed wound healing, pulmonary disease, eye diseases and pathological condition related to severe infection.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: January 23, 2018
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Shmuel Ben-Sasson, Hadas Reuveni
  • EXPANDABLE VERTEBRAL BODY REPLACEMENT DEVICE AND METHOD
    Publication number: 20180014942
    Abstract: An expandable vertebral body device, system, instrument, and methods of assembly and using the device, system, and instrument are disclosed. The vertebral body device includes a body with a first end and a second end, a first rotating member rotatably coupled to the first end, a second rotating member rotatably coupled to the second end, a first extension member moveably coupled to the first end, and a second extension member moveably coupled to the second end. The expandable cage system comprises a vertebral body device and an insertion instrument. Methods for assembling and using the vertebral body device and instrument are also disclosed.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 18, 2018
    Applicant: MUSC Foundation for Research Development
    Inventors: Mark Evald SEMLER, Bruce FRANKEL, Joseph RUSCITO
  • SPIROFURANONE COMPOUNDS, DERIVATIVES THEREOF AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20180016221
    Abstract: The present invention provides compounds comprising fused tricyclic backbone structure and processes for their preparation. The invention further provides compounds and compositions useful in the treatment of pain and any type of disorder or symptom associated therewith.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 18, 2018
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Dmitry TSVELIKHOVSKY, Avi PRIEL
  • Ladostigil therapy for immunomodulation
    Patent number: 9867798
    Abstract: Methods for treating individuals suffering from inflammation, specifically systemic inflammation including septic shock and inflammatory conditions affecting the gastrointestinal, myocardial and endocrine systems with ladostigil.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: January 16, 2018
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Marta Weinstock-Rosin
  • Vascular delivery systems
    Patent number: 9867884
    Abstract: The site-specific expression of selectins on endothelial cells of blood vessels during angiogenesis provides an opportunity to target anti-cancer drugs to the vascular endothelium to extend the range of the therapeutic effect. This invention describes an innovative drug targeting strategy for the selective delivery of the anticancer drugs to endothelial cells by means of polymer-drug conjugates modified with a carbohydrate ligand for the vascular selectins. A model chemotherapeutic drug, doxorubicin, and the E-selectin ligand, sLex, are attached to a biocompatible polymer (HPMA). The selective binding, cellular uptake, intracellular fate, and cell cytotoxicity of the polymer-bound drug are investigated in human endothelial cells.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: January 16, 2018
    Assignee: Ben-Gurion University of Negev Research & Development Authority
    Inventors: Ayelet David, Gonen Ashkenasy, Yosi Shamay
  • Double balloon catheter
    Patent number: 9861795
    Abstract: A catheter including a plurality of balloons extending from the outer surface of the catheter that when inflated create a seal between the catheter and the patient's thereby eliminating leakage of fluids from around catheter during the procedure.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: January 9, 2018
    Assignee: MUSC Foundation for Research Development
    Inventors: Cephus Simmons, Rebecca Copenhaver DeLegge
  • Diagnostic and therapeutic methods and their application in amyotrophic lateral sclerosis (ALS)
    Patent number: 9861686
    Abstract: The present invention provides a method of treating, delaying the onset, delaying progression of, reducing the incidence of or reducing the severity of amyotrophic lateral sclerosis in a subject, the method comprising administering to a subject an agent, which interferes with IgG-A2BG2 expression, IgG-A2BG2 function or IgG-A2BG2 interaction with CD16 in said subject.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: January 9, 2018
    Assignee: Ben-Gurion University of the Negev Research & Development Authority
    Inventors: Angel Porgador, Rachel Lichtenstein
  • Vehicle comprising collision control system, collision control system and method
    Patent number: 9862402
    Abstract: Collision control system (40) for controlling deflection of an instrument cluster (30) in a vehicle during collision. Said collision control system (40) comprises a steering assembly (10) including a steering wheel (12) and a steering column (11), a cross car beam (20) comprising a first sliding surface (22), and an instrument panel assembly (35) including an instrument cluster (30) and a second sliding surface (32), which is arranged to abut and slide along said first sliding surface (22) during said collision. During collision said steering column (11) is configured to move forward in a controlled manner and said steering column assembly (10) is arranged to push said instrument cluster (30), such that said second sliding surface (32) of said instrument panel assembly (35) slides along the first surface (22) for controlled deflection of the instrument cluster (30).
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: January 9, 2018
    Assignee: Ningbo Geely Automobile Research & Development Co., Ltd.
    Inventors: Tony Earl, Urban Wendt
  • ANTI-MICROBIAL PEPTIDES AND USES OF SAME
    Publication number: 20180002376
    Abstract: A method of treating a bacterial infection in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a peptide being between 3 and 5 amino acids, wherein at least one amino acid of the 3 and 5 amino acids is selected from the group consisting of tryptophan, cysteine, proline and methionine.
    Type: Application
    Filed: September 7, 2017
    Publication date: January 4, 2018
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Noam ADIR, Sharon NAVON, Tali SCHWARTZMAN
  • LIQUID-CORE CAPSULES COMPRISING NON-CROSSLINKED ALGINATE
    Publication number: 20180001291
    Abstract: Provided are hydrocolloid core-shell capsules including a liquid core including a non-crosslinked alginate solution and a solid or semi-solid shell including a hydrocolloid other than alginate crosslinked with metal ions, which do not crosslink alginate. Further provided is a method for the preparation of the liquid-core capsules including non-crosslinked alginate. The subject matter further provides the use of the capsules, inter alia, in the water treatment technology.
    Type: Application
    Filed: December 29, 2015
    Publication date: January 4, 2018
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Amos NUSSINOVITCH, Orit DAGAN
  • Compositions and methods for promoting wound healing and tissue regeneration
    Patent number: 9855313
    Abstract: Provided herein are compositions and methods for use in promoting wound healing and tissue regeneration following tissue injury in a subject.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: January 2, 2018
    Assignee: MUSC Foundation for Research Development
    Inventors: Gautam Ghatnekar, Robert Gourdie, Jane Jourdan
  • Thiazole compounds, compositions and methods for treatment of degenerative diseases and disorders
    Patent number: 9850218
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: December 26, 2017
    Assignee: MUSC Foundation For Research Development
    Inventors: Craig C. Beeson, Christopher C. Lindsey, Yuri K. Peterson, Baerbel Rohrer
  • Vaccines and diagnostics for the ehrlichioses
    Patent number: 9850295
    Abstract: The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. chaffeensis VLPT are disclosed.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: December 26, 2017
    Assignee: Research Development Foundation
    Inventors: Jere W. McBride, Tian Luo
  • Method and apparatus for fiberscope employing single fiber bundle for co-propagation of image and illumination
    Patent number: 9848761
    Abstract: An exemplary embodiment providing one or more improvements includes an endoscope which utilizes a single coherent fiber bundle for simultaneously carrying imaging and illumination light.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 26, 2017
    Assignee: Research & Development International, Inc.
    Inventors: Joseph R. Demers, Marek Sekowski
  • Apparatus for use in luminescence applications
    Patent number: 9851302
    Abstract: Photoluminescence from a sample detector is detected using an array of photo-sensitive detectors. At least one first photo-sensitive detector of the array is provided with a first type of linear polarization filter and at least one second photo-sensitive detector is provided with a second type of linear polarization filter. The first type of linear polarization filter has a plane of polarization which is at angled with respect to a plane of polarization of said second type of polarization filter.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: December 26, 2017
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Francescopaolo Mattioli Della Rocca, John Kevin Moore