Abstract: The present invention concerns a method of purifying a biological liquid comprising antibodies corresponding to whole human or animal blood or to a product obtained from human or animal blood, by bringing a biological liquid into contact with at least one substrate comprising a solid phase onto which molecules of at least one oligosaccharide are grafted by covalent bonding, the molecules of the at least one oligosaccharide being capable of binding to one or more of said antibodies present in said biological liquid, in a manner such as to capture at least a portion of said antibodies present in said biological liquid by binding with at least certain of the molecules of oligosaccharide(s) grafted onto said solid phase, characterized in that said solid phase carries free aldehyde functions —CHO.
Type:
Grant
Filed:
May 3, 2016
Date of Patent:
August 25, 2020
Assignees:
ELICITYL, RESEARCH FOUNDATION FOR MEDICAL DEVICES
Abstract: The invention relates to a novel method of virally inactivating biological fluids by solvent/detergent treatment of the fluid, followed by oil extraction and filtration.
Type:
Application
Filed:
March 25, 2009
Publication date:
February 10, 2011
Applicant:
Research Foundation For Medical Devices
Inventors:
Thierry Burnouf, Magdy El-Ekiaby, Hadi Alphonse Goubran, Miryana Radosevich
Abstract: The invention relates to the use of polyoxyethylene (4-5) p-t-octyl phenol (t-Oct-C6H4—(OCH2CH2)x0H, x=˜5) or polyoxyethylene (20) sorbitan monooleate in solvent/detergent viral inactivation of biological fluids for the preparation of a virally inactivated biological fluid having a high alpha 2-antiplasmin content.
Type:
Application
Filed:
February 14, 2008
Publication date:
July 1, 2010
Applicant:
RESEARCH FOUNDATION FOR MEDICAL DEVICES
Inventors:
Thierry Burnouf, Magdy El-Ekiaby, Hadi Alphonse Goubran, Miryana Radosevich