Abstract: The present invention is directed to a method of predicting the binding affinity between a first molecular entity and a second molecular entity. The method includes (1) calculating the free energy of binding ?Gbind between the first molecular entity and the second molecular entity according to the equation (17): ?Gbind=?0.82?X+/?+0.064?Xc/s?0.6Xsb?0.93Xhb?0.0007Xgap?0.06?Xtor?0.36??(17) where X+/? is the total number of exposed charged groups; Xc/s is the total number of exposed hydrophobic groups; Xsb is the total number of salt bridges; Xhb is the total number of hydrogen bonds; Xgap is the gap volume at the interface of the first molecular entity and the second molecular entity; Xtor is the total number of exposed side chain torsions; and where ? refers to the difference between the bound and unbound states; and (2) evaluating the free energy of binding to predict the binding affinity between the first and second molecular entities.

Abstract: A method of treating ras-transformed and ras-related cancer, including: administering to a plurality cells, including ras-transformed cancer cells and normal cells, a peptide material having a membrane resident peptide and a ras-p21 component, the membrane resident peptide attached to the carboxyl or amino terminal end of the ras-p21 component.

Abstract: The present invention discloses methods of preparing a continuous, porous metal oxide monolith in a container. The method involves providing a reaction mixture containing a metal salt or metal alkoxide compound, a solvent, and a porogenic reagent. Next, an epoxide is added to the reaction mixture under conditions effective to initiate condensation and polymerization of the reaction mixture. Then, a container is filled with the reaction mixture after epoxide addition to obtain a continuous, porous metal oxide monolith in the container. The present invention also discloses columns including a tubular container and a continuous, porous Group IV metal oxide monolith in contact with the inner walls of the tubular container, where the Group IV metal oxide monolith is free of any support or matrix material, and other articles including a continuous, porous Group IV metal oxide monolith, where the metal oxide monolith is free of any support or matrix material.

Abstract: A hybrid CMOL stack enables more efficient design of CMOS logical circuits. The hybrid CMOL structure includes a first substrate having a CMOS device layer on the substrate, a first interconnect layer with interface pins over the CMOS device layer of the first substrate, a first array of nanowires connected to the interface pins of the first interconnect layer, a layer of nanowire junction material over the first array of nanowires, a second array of nanowires over the nanowire junction material, a second interconnect layer having interface pins disposed over the second array of nanowires, the interface pins being connected to the second array of nanowires, and a second substrate, the second substrate including a second CMOS device layer disposed over the second interconnect layer.

Abstract: Systems and methods for digital detection of an analog tomographic signal are described. The methods include receiving an amplitude-modulated analog signal containing tomographic information, the analog signal having a modulation frequency, f?i; and converting the analog signal into a digital signal at a sampling frequency, fs, to produce a number of samples, K. The digital signal is multiplied by an in-phase reference signal to obtain an in-phase signal component, the in-phase reference signal having the frequency, f?i; and the digital signal is multiplied by a quadrature reference signal to obtain a quadrature signal component, the quadrature reference signal having the frequency, f?i. The in-phase signal component and the quadrature signal component are passed through the K-point averaging filter. A signal amplitude is computed based on the filtered in-phase signal component and the filtered quadrature signal component, the signal amplitude being representative of the tomographic information.

Abstract: The invention comprises a system and method for determining at least one material property of a material sample (such as a bone sample) at at least one point. The system includes a transmitting ultrasonic transducer and a receiving ultrasonic transducer, both transducers being confocal transducers. The transducers are configured to receive the material sample therebetween such that the confocal point of the transducers are located at the at least one point in the material sample. A processor initiates an ultrasonic signal from the transmitting transducers that is transmitted trough the at least one point of the material sample when positioned between the transducers. The ultrasonic signal is received by the receiving transducing and the processor in turn receives a signal reflecting one or more measures of the received ultrasonic signal. The processor determines at least one ultrasonic parameter for the at least one point of the material sample based upon the transmitted and received ultrasonic signals.

Abstract: The present invention relates to the isolation, purification, and use of novel mammalian DExH box helicases. In particular, the present invention relates to the isolation, purification and use of DHX29, a novel mammalian RNA helicase.

Abstract: A method for the formation of metallic nanoparticles, such as gold and silver nanoparticles, which involves, combining in a single solution, solvent, metal ions and copolymers under conditions such that metal nanoparticles are formed. The copolymers have both reducing components and stabilizing components. The method can be used to form metal nanoparticles having a desired shape and size.

Abstract: A portable, lightweight, rugged, easy-to-operate biosensor useful for rapidly detecting cells, viruses, antibodies, and other proteins. A capillary tube has a capture antibody immobilized on its interior surface. The specific capture antibody is selected based upon a desired target analyte to be detected. A sample potentially containing the target antigen is introduced into the capillary tube. Thereafter, a second antibody labeled with a fluorescent dye is introduced. Upon excitation by electromagnetic energy, typically supplied by a laser, the fluorescence of the sample is captured and analyzed. The apparatus is extremely compact and rugged making it ideal for field use. In addition, accurate results may be obtained by relatively unskilled operators directly from a self-contained readout. Optionally, an external device (e.g., a computer) may be connected to the apparatus via an optional interface.

Abstract: A method for fabricating an electronic device comprises providing a substrate (501), direct writing a functional material by a thermal spray on the substrate (502) and removing a portion of the function material to form the electronic or sensory device (503).

Abstract: A composition which includes polymethylmethacrylate and an organoclay functionalized with an intercalation agent, wherein said intercalation agent is a reaction product of a polyamine and an alkyl halide in a polar solvent, preferably a di-methyl, di-tallow ammonium functionalized montmorillonite clay.

Abstract: Virtual navigation (2255) and examination of virtual objects are enhanced using methods of insuring that an entire surface to be examined has been properly viewed. A user interface (FIG. 23) identifies regions which have not been subject to examination and provides a mechanism (2250) to route the user to these regions in the 3D display. Virtual examination is further improved by the use of measuring disks (905) to enhance quantitative measurements such as diameter, distance, volume and angle. Yet another enhancement to the virtual examination of objects is a method of electronic segmentation, or cleaning, which corrects for partial volume effects occurring in an object.

Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.

Abstract: The present invention provides a method of treating diabetes, including administering to a mammal diagnosed with diabetes a purified recombinant reg I protein.

Abstract: Disclosed are compounds having the formula: wherein R21 is an alkyl, aryl, alkoxy, hydroxy, or amino group or a halogen atom; wherein R2 is hydrogen or an alkyl, aryl, alkoxy, or amino group; wherein R23 and R24 are independently selected from hydrogen, an alkyl, aryl, alkoxy, hydroxy, or amino group, and a halogen atom or wherein R23 and R24, taken together with the carbon atom to which they are bound, form a ring; wherein R25 is hydrogen, an alkyl, aryl, alkoxy, hydroxy, or O-silyl group or a halogen atom; wherein Z, taken together with the carbons to which it is bonded, forms a 5-12 membered ring; and wherein Y is an electron withdrawing group. These compounds can be used to prepare erogorgiaene congeners, such as erogorgiaene, pseudopterosin A, helioporin E, pseudopteroxazole, colombiasin A, elisapoterosin B, elisabethadione, p-benzoquinone natural products, ileabethin, sinulobtain B, sinulobtain C, and sinulobtain D.

Abstract: A process of making biodiesel from crude tall oil by reacting crude tall oil with a C1-C6 alkanol in the presence of an acid catalyst or by reacting crude tall oil with an acyl halide in the presence of a C1-C6 alkanol. The reaction product of either of these reactions is separated into a suspension liquid by the addition of a polar liquid. The biodiesel product is recovered from the suspension liquid by addition of an organic solvent which produces a polar liquid phase and an organic liquid phase. The biodiesel is recovered from the organic liquid phase by evaporating the organic solvent, which is recovered for use in subsequent separation processes, and vacuum distilling off the product biodiesel from the organic solvent-free organic liquid phase.

Abstract: The present invention relates to inhibiting angiogenesis with sulfur- or selenium-containing compounds, and polymeric forms thereof, in mammals including animals and humans. Sulfur- or selenium-containing compounds, and polymeric forms thereof, can be used alone or in combination with standard therapies to inhibit angiogenesis-mediated disorders. The present invention also relates to the combined use of sulfur- or selenium-containing compounds, and polymeric forms thereof, with other anti-angiogenesis agents, with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer, and with laser, photodynamic therapy for ocular-related disorders such as diabetic retinopathy or age-related macular degeneration.

Abstract: A method of preparing carbon-loaded, gold-based nanoparticle catalysts useful as anode catalysts for the electrocatalytic methanol oxidation reaction (MOR) as well as the oxygen reduction reaction (ORR). AumPtnM100-m-n catalysts may be prepared by either a two-phase protocol or by a thermal decomposition/reduction protocol. The prepared nanoparticles having different bimetallic ratios are assembled on carbon black support materials and activated by thermal treatment. This approach provides good control of nanoparticle size, composition and/or surface properties. Electrocatalytic MOR activities of the prepared and activated AuPt nanoparticle provided in accordance with the methods of the invention are present in both acidic and alkaline electrolytes.

Abstract: The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the metastatic potential of such cancer cells and drug screening assays for the identification of agents having anti-metastatic potential. The present invention further provides methods and compositions for inhibiting the metastatic potential of cancer cells by modulating the activity of serine integral membrane proteases [(SIMP) consisting of seprase and dipetidyl peptidase IV (DPPIV)] expressed on the surface of metastasizing cancer cells.

Abstract: The present invention is directed to compounds having the formula: In the formula, A2 represents N or C—X1a—R1 and A4 represents N or C—X2b—R2, provided that A2 and A4 are not both N. R1 and R2 independently represent H or a hydrocarbon group, provided that R1 and R2 are not both H. The hydrocarbon groups of R1 and R2 are preferably alkyl or alkenyl groups. More preferably, the hydrocarbon groups are alkyl groups. A1, A3, A6, and A8 independently represent CH or N. A5 and A9 independently represent CR3 or N, wherein R3 independently represents H, methyl, ethyl, or halo. A7 represents CR4 or N, wherein R4 represents H, methyl, ethyl, halo, nitro, hydroxy, amino, amido, or a methyl or ethyl group substituted independently with halo, nitro, hydroxy, amino, or amido. Not more than three of A5, A6, A7, A8, and A9 are N.