Abstract: The present invention provides for a composition and formulations comprising an extract from Clerodendrum viscosum, and a method of obtaining the extract. The present invention also provides for a method of treating any disease where uncontrolled cellular proliferation occurs, such as cancers. In particular, the present invention provides a method for treating cervical cancer. The present invention also provides methods to inhibit proliferation and induce apoptosis of cancer cells.
Type:
Grant
Filed:
November 13, 2013
Date of Patent:
August 28, 2018
Assignee:
RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
Abstract: A method of delivering a transgene to a cell is provided. The method uses a vector that contains a T-cell receptor alpha locus control region (TCR?LCR) derived gene regulatory cassette having fewer than 5.0-kb. The method delivers the transgene with spatiotemporally specific gene expression and silencing-prevention controls to a cell such that a predetermined subset of progeny cell-types express a gene product from the transgene. Other progeny of the cell diminish, or silence, the expression of the gene product.
Type:
Grant
Filed:
May 11, 2015
Date of Patent:
August 21, 2018
Assignee:
Research Foundation of the City University of New York
Abstract: Self-suspending proppants including proppant particles coated with a CO2-philic coating are provided. The CO2-philic coating may be lightly crosslinked and may have a physical structure that constrains CO2 molecules. Methods of making self-suspending proppants may include coating a proppant particle with a polymerizable precursor material of a CO2-philic material and polymerizing the polymerizable precursor material to form a self-suspending proppant are also provided. Additionally, hydraulic fracturing fluids that may include a CO2-based fluid and the self-suspending proppants and methods of treating subterranean formations by contacting a subterranean formation with hydraulic fracturing fluid and propagating at least one subterranean fracture are provided.
Type:
Application
Filed:
September 12, 2017
Publication date:
August 16, 2018
Applicants:
Aramco Services Company, Research Foundation of The City University of New York
Inventors:
Feng Liang, Ghaithan A. Al-Muntasheri, Leiming Li, B. Raghava Reddy, George John, Vidyasagar Adiyala
Abstract: Self-suspending proppants including proppant particles coated with a CO2-philic coating are provided. The CO2-philic coating may be lightly crosslinked and may have a physical structure that constrains CO2 molecules. Methods of making self-suspending proppants may include coating a proppant particle with a polymerizable precursor material of a CO2-philic material and polymerizing the polymerizable precursor material to form a self-suspending proppant are also provided. Additionally, hydraulic fracturing fluids that may include a CO2-based fluid and the self-suspending proppants and methods of treating subterranean formations by contacting a subterranean formation with hydraulic fracturing fluid and propagating at least one subterranean fracture are provided.
Type:
Application
Filed:
March 15, 2018
Publication date:
August 16, 2018
Applicants:
Aramco Services Company, Research Foundation of The City University of New York
Inventors:
Feng Liang, Ghaithan A. Al-Muntasheri, Leiming Li, B. Raghava Reddy, George John, Vidyasagar Adiyala
Abstract: Self-suspending proppants including proppant particles coated with a CO2-philic coating are provided. The CO2-philic coating may be lightly crosslinked and may have a physical structure that constrains CO2 molecules. Methods of making self-suspending proppants may include coating a proppant particle with a polymerizable precursor material of a CO2-philic material and polymerizing the polymerizable precursor material to form a self-suspending proppant are also provided. Additionally, hydraulic fracturing fluids that may include a CO2-based fluid and the self-suspending proppants and methods of treating subterranean formations by contacting a subterranean formation with hydraulic fracturing fluid and propagating at least one subterranean fracture are provided.
Type:
Application
Filed:
March 15, 2018
Publication date:
August 16, 2018
Applicants:
Aramco Services Company, Research Foundation of The City University of New York
Inventors:
Feng Liang, Ghaithan A. Al-Muntasheri, Leiming Li, B. Raghava Reddy, George John, Vidyasagar Adiyala
Abstract: A method for isomerizing a double bond is provided. A substrate is exposed to an isomerase enzyme, wherein the isomerase enzyme comprises a redox-regulated ligand switch and heme b cofactor. A reducing agent is added which changes iron (III) to iron (II). The enzyme isomerizes double bonds in the iron (II) state but not in the iron (III) state. In one embodiment, the enzyme is homologous with 15-cis-?-carotene isomerase (Z-ISO).
Type:
Grant
Filed:
June 1, 2016
Date of Patent:
July 31, 2018
Assignee:
Research Foundation of the City University of New York
Abstract: The present invention discloses novel compounds derived from NSAIDs and pharmaceutically acceptable salts thereof. Other aspects of the invention relate to use of the NSAID derivatives in treating inflammatory diseases and pharmaceutical compositions thereof.
Type:
Grant
Filed:
February 7, 2014
Date of Patent:
July 17, 2018
Assignee:
RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
Abstract: A system and method to treat neuromuscular conditions, including spinal cord injury, by what is characterized as dipole (two point) cortico-muscular stimulation. Two-point stimulation, with oppositely charged electrodes, allows pulsed, direct current to pass through the cortico-muscular pathway. The electrodes are placed on nerves, muscles, or a combination of both, that are on opposite sides of the spinal column, forming a current that passes across the spinal column. Further, an active electrode can be placed on the spinal column and a reference electrode can be placed outside the central nervous system. These methods improve functional recovery of the motor pathway.
Type:
Grant
Filed:
May 25, 2016
Date of Patent:
June 26, 2018
Assignee:
THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
Abstract: A method for forming a superhydrophobic surface is disclosed. A surface of a first substrate is bonded to a surface of a second substrate to form a stacked material. The stacked material is peeled apart to form a fracture line and provide a superhydrophobic surface.
Type:
Grant
Filed:
January 16, 2015
Date of Patent:
June 5, 2018
Assignee:
Research Foundation of the City University of New York
Abstract: A system and method to treat neuromuscular conditions, including spinal cord injury, by what is characterized as dipole (two point) cortico-muscular stimulation. Two-point stimulation, with oppositely charged electrodes, allows pulsed, direct current to pass through the cortico-muscular pathway. The electrodes are placed on nerves, muscles, or a combination of both, that are on opposite sides of the spinal column, forming a current that passes across the spinal column. Further, an active electrode can be placed on the spinal column and a reference electrode can be placed outside the central nervous system. These methods improve functional recovery of the motor pathway.
Type:
Grant
Filed:
October 11, 2016
Date of Patent:
May 22, 2018
Assignee:
THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
Abstract: An electrode assembly includes a substantially porous element configured to be coupled to an electrode for delivery of electrical current to a patient in a neurostimulation procedure. The substantially porous material defining a contact surface, of which at least a portion contacts the patient during the neurostimulation procedure. A first insulating member is coupled to the substantially porous element and exposed at the contact surface to prevent a portion of the contact surface from contacting the patient to deliver the electrical current during the neurostimulation procedure.
Type:
Grant
Filed:
October 19, 2011
Date of Patent:
May 1, 2018
Assignee:
RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
Abstract: Fluorescent proteins (Chlopsid FP I from Kaupichthys hyoproroides and Chlopsid FP II from Kaupichthys n. sp.) are used in a method for detecting bilirubin. The proteins are based on transcriptome analysis of the false moray eels, Kaupichthys hyoproroides and Kaupichthys n. sp., the later representing a heretofore undescribed species.
Type:
Grant
Filed:
November 10, 2016
Date of Patent:
April 24, 2018
Assignees:
Research Foundation of the City University of New York, John B. Pierce Laboratory
Inventors:
David F. Gruber, Jean P. Gaffney, Vincent A. Pieribone
Abstract: A system for producing a public ring that is fully homomorphically encrypted. The system comprises a processor which generates a first presentation G of a ring, where G=x,y|x2=0,y2=0,xy+(p+1)yx=1, where x and y are generators and p is a first private prime number. The system further generates a second presentation H of the ring. H is defined as follows: H=x,y,t|x2=0,y2=0,t=m1yx,xy+m2yx+t=1. In addition, m1 and m2 are positive integers and p+1=m1+m2, wherein t is a generator and the first presentation G and the second presentation H are isomorphic. The system further produces a public ring ? that is fully homomorphically encrypted, where: H ^ = ? x , y , t ? N · 1 = 1 , x 2 = 1 , y 2 = 0 , xyx = x , yxy = y , tx = 0 , yt = 0 , t 2 = t + m 2 2 - m 2 m 1 ? tyx ? , N=pq and further, q is a second private prime number, and the public ring ? is further, publically available. A corresponding method is also disclosed.
Type:
Grant
Filed:
August 25, 2015
Date of Patent:
April 10, 2018
Assignee:
Research Foundation of the City University of New York
Inventors:
Delaram Kahrobaei, Ha T. Lam, Vladimir Shpilrain
Abstract: A method for tracking three-dimensional movement of an object and focusing thereon is provided. Software repeatedly detects three-dimensional locations of one or more objects and image quality by sampling images at many parameter settings as the objects move in three-dimensional environment. The images are ranked occurring to a fitness score and parameter settings for subsequent images to established using a biologically-inspired algorithm.
Type:
Grant
Filed:
September 14, 2015
Date of Patent:
March 27, 2018
Assignee:
Research Foundation of the City University of New York
Abstract: In one embodiment, the invention provides a method of purifying recombinant alpha-galactosidase A. The method includes obtaining a lysate from cells recombinantly expressing alpha-galactosidase A grown in a cell culture medium having non-precipitating phosphate; contacting said lysate with a first chromatography media that binds ?-D-mannopyranosyl or ?-D-glucopyranosyl; eluting alpha-galactosidase A from the first chromatography media to generate a first eluate having alpha-galactosidase A, wherein said eluting includes at least one elution pause between 4 and 16 hours; contacting the first eluate with a second chromatography media that binds galactose binding proteins; and eluting alpha-galactosidase A from said second chromatography media to generate a second eluate containing said recombinant alpha-galactosidase A.
Type:
Grant
Filed:
June 5, 2015
Date of Patent:
March 6, 2018
Assignee:
RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
Abstract: The subject matter disclosed herein pertains to the modulation of a bacterial invasion switch and the subsequent use of the bacterium to vaccinate an organism. In one embodiment, the bacterial invasion switch is modulated by changing the proteolysis of ExoR protein. In another embodiment, a mutated bacterium produces a mutant ExoR protein that resists proteolysis.
Type:
Grant
Filed:
September 14, 2015
Date of Patent:
February 13, 2018
Assignee:
Research Foundation of the City University of New York
Abstract: A time reversal optical tomography (TROT) method for near-infrared (NM) diffuse optical imaging of targets embedded in a highly scattering turbid medium is presented. TROT combines the basic symmetry of time reversal invariance and subspace-based signal processing for retrieval of target location. The efficacy of TROT is tested using simulated data and data obtained from NIR imaging experiments on absorptive, scattering and fluorescent targets embedded in Intralipid-20% suspension in water, as turbid medium, as well as, a realistic cancerous model breast assembled using ex vivo human breast tissues with two embedded tumors. The results demonstrate the potential of TROT for detecting and locating small targets in a turbid medium, such as, breast tumors in early stages of growth.
Type:
Grant
Filed:
October 22, 2013
Date of Patent:
January 16, 2018
Assignee:
Research Foundation of the City University of New York
Abstract: A method and device for extracting oil from food waste is disclosed. Food waste is introduced into an elongated cylinder that is immersed under hot water. A drive shaft is actuated that simultaneously presses the food waste against an interior wall and moves the food waste through the cylinder. The content of the cylinder is subjected to steam treatment using a steam inlet in the cylinder. The combination of hot water, steam treatment and pressing recovers a high content of oil from the food waste.
Type:
Application
Filed:
December 14, 2015
Publication date:
December 28, 2017
Applicant:
Research Foundation of the City University of New York
Abstract: A method for enhancing amidohydrolase activity of Fatty Acid Amide Hydrolase (FAAH) is disclosed. The method comprising administering a phenoxyacyl-ethanolamide that causes the enhanced activity. The enhanced activity can have numerous effects on biological organisms including, for example, enhancing the growth of certain seedlings.
Type:
Grant
Filed:
September 15, 2016
Date of Patent:
December 26, 2017
Assignees:
Research Foundation of the City University of New York, The Curators of the University of Missouri, University of North Texas
Inventors:
George John, Subbiah Nagarajan, Kent Chapman, Lionel Faure, Peter Koulen
Abstract: PVT1 exon 9 is overexpressed in aggressively tumorigenic prostate cancer cell lines and prostate tumor tissues. This exon provides a diagnostic tool for the detection and monitoring of aggressive prostate cancer. Several small interfering ribonucleic acids (siRNAs) are disclosed that are useful for treating prostate cancer.
Type:
Grant
Filed:
November 7, 2016
Date of Patent:
December 19, 2017
Assignee:
Research Foundation of the City University of New York
Inventors:
Olorunseun O. Ogunwobi, Adeodat Ilboudo, Chunxiao Ying