Abstract: The invention relates to a method for increasing the production level of isoprenoids in an algal cell. The method includes increasing expression of a polynucleotide sequence that encodes 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (IDS) in the algal cell. In another aspect, the invention relates to a method for increasing the production level of carotenoids in an algal cell. The method includes increasing expression of polynucleotide sequence that encodes phytoene desaturases (PDS) in the algal cell. In a further aspect, the invention relates to an algal cell having a polynucleotide sequence that is genetically engineered to express a higher level of IDS or PDS than a corresponding wild type algal cell, wherein the cell produces an increased level of isoprenoids or carotenoids, respectively, than a corresponding wild type algal cell.
Type:
Application
Filed:
April 24, 2009
Publication date:
March 1, 2012
Applicant:
The City University of New York represented by the Research Foundation of the City University of NY
Abstract: The present invention provides multi-arm siloxane-based molecules suitable for use as a drug delivery vehicle comprising a central core molecule that comprises a cyclic or cubic siloxane, and a plurality of arms attached to the central core molecule, wherein each arm comprises an organic moiety. The multi-arm siloxane-based molecules described herein are suitable for encapsulation of a therapeutic agent. The invention further includes pharmaceutical compositions comprising the claimed multi-arm siloxane-based molecules and an encapsulated therapeutic agent in combination with a pharmaceutically acceptable carrier. Methods of making and using the multi-arm siloxane-based molecules are also provided.
Type:
Grant
Filed:
August 7, 2006
Date of Patent:
June 29, 2010
Assignees:
Becton, Dickinson and Company, Research Foundation of the City University of NY
Inventors:
Andrew Auerbach, Bhanu P. S. Chauhan, Richard P. Clarke, M. Ishaq Haider, Umar Latif