Patent number: 7268157
Abstract: Disclosed is the preparation and pharmaceutical use of substituted arylalcanoic acid derivatives of Formula I, wherein ring A, ring B, R1, R2, R3, R4, R5, X, Alk1, Alk2, Ar1, and Ar2 are as defined in the specification. These compounds, as selective agonists activating peroxisome proliferator-activated receptors (PPAR), in particularly the RXR/PPARalpha, RXR/PPARgamma, and RXR/PPARdelta heterodimers, are useful in the treatment and/or prevention of type 2 diabetes and associated metabolic syndrome such as hypertension, obesity, insulin resistance, hyperlipidemia, hyperglycemia, hypercholesterolemia, atherosclerosis, coronary artery disease, and other cardiovascular disorders with improved side effects profile commonly associated with conventional PPARgamma agonists.
Type:
Grant
Filed:
November 18, 2003
Date of Patent:
September 11, 2007
Assignees:
Shenzhen Chipscreen Biosciences, Ltd., Research Institute of Tsinghua University
Inventors:
Xian-Ping Lu, Zhibin Li, Chenzhong Liao, Leming Shi, Zhende Liu, Baoshun Ma, Zhiqiang Ning, Song Shan, Tuo Deng