Abstract: Provided are methods of increasing metabolic maturation of an immature hepatocyte, by contacting an immature hepatocyte which expresses alpha-fetoprotein (AFP) and albumin with an effective amount of a fatty acid or a small molecule selected from the group consisting of: an amphipathic carboxylic acid, Thiazolidinedione (TZD), WY-14643 (Pirinixic Acid), GW409544, GW6471, Leukotriene B4, GW 7647, Perfluorooctanesulfonic Acid, Perfluorooctanoic Acid, CP-775146, CP-865520, UNII-999KY5ZIGB, and Gemfibrozil. Also provided are isolated hepatocytes and uses thereof.
Type:
Grant
Filed:
March 15, 2017
Date of Patent:
September 15, 2020
Assignee:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
Inventors:
Yaakov Nahmias, Michal Zimerman, Gahl Levy, Yishai Avior
Abstract: The present invention is directed at stabilization of aqueous urea solutions containing organometallic catalyst precursors. Stabilization can be achieved by monitoring and controlling the solution pH.
Abstract: The present invention provides a dewatering device for an air-conditioning system of a plane, comprising: one or more filter plates disposed within a mixing cavity of an air-conditioning system of a plane, for filtering liquid-state water in mixed air in the mixing cavity, wherein the filter plates are configured to be inclinable relative to an axis of the mixing cavity, and an inclination angle thereof is adjustable so as to change a filtering amount of the mixed air.
Type:
Grant
Filed:
September 22, 2015
Date of Patent:
September 15, 2020
Assignees:
COMMERCIAL AIRCRAFT CORPORATION OF CHINA, LTD, COMMERCIAL AIRCRAFT CORPORATION OF CHINA, LTD SHANGHAI AIRCRAFT DESIGN AND RESEARCH INSTITUTE
Abstract: A wearable paper-based platform with simultaneous passive and active feedback for monitoring perspiration is provided. The sensor platform comprises two modules: a disposable wicking-based sweat collection patch with discrete colorimetric feedback, and a reusable electronic detachable module for active feedback. The disposable patch comprises a hygroscopic wicking material laminated between two polymeric films. The wicking material is patterned with a radial finger design that offers discretized visual readout of the sensor. The active module attaches to the film and alerts the user when the film collects a pre-determined volume of sweat. The multi-feedback system allows high-performance athletes who value objective quantification of perspiration to better assess their sweat loss during physical activities.
Type:
Grant
Filed:
October 2, 2017
Date of Patent:
September 15, 2020
Assignee:
Purdue Research Foundation
Inventors:
Babak Ziaie, Manuel P. Ochoa, Vaibhav Jain, Rahim Rahimi
Abstract: Disclosed is a quasi-circulator using an asymmetric directional coupler. The quasi-circulator using the asymmetric directional coupler according to an embodiment of the present invention may enhance a characteristic of isolating a transmitting signal from a receiving signal with the same characteristic as transmitting signal loss of a symmetric directional coupler in the related art by arranging impedance of each line of a directional coupler asymmetrically.
Type:
Grant
Filed:
August 22, 2018
Date of Patent:
September 15, 2020
Assignee:
RESEARCH COOPERATION FOUNDATION OF THE YEUNGNAM UNIVERSITY
Inventors:
Jong Ryul Yang, Bo Yoon Yoo, Ha Neul Lee, Ju Hee Son
Abstract: Optoelectronic devices that use very thin single-crystalline inorganic semiconductor films as phonon-absorbing layers in combination with non-lattice optical cavities are provided.
Type:
Grant
Filed:
June 2, 2017
Date of Patent:
September 15, 2020
Assignees:
Wisconsin Alumni Research Foundation, The Research Foundation for the State University of New York
Abstract: An apparatus for generating broadcast signal frame according to an embodiment of the present invention includes a combiner configured to generate a multiplexed signal by combining a core layer signal and an enhanced layer signal; a power normalizer configured to reduce power of the multiplexed signal to a power level corresponding to the core layer signal; a time interleaver configured to generate a time-interleaved signal by performing time-interleaving that is applied to both the core layer signal and the enhanced layer signal; and a frame builder configured to generate a broadcast signal frame including a preamble for signaling start position information and size information for each of Physical Layer Pipes (PLPs). In this case, the Physical Layer Pipes include a core layer physical layer pipe corresponding to the core layer signal and an enhanced layer physical layer pipe corresponding to the enhanced layer signal.
Type:
Grant
Filed:
July 5, 2017
Date of Patent:
September 15, 2020
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Bo-Mi Lim, Sung-Ik Park, Sun-Hyoung Kwon, Jae-Young Lee, Heung-Mook Kim, Nam-Ho Hur
Abstract: Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.
Type:
Grant
Filed:
March 10, 2017
Date of Patent:
September 15, 2020
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: Methods of preventing or decreasing PEDv and/or Salmonella bacteria in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids, essential oils, and sodium bisulfate. The chemical mitigants are introduced to the feed or feed ingredients at inclusion rates selected so as to prevent or decrease PEDv and/or Salmonella bacteria in the animal feed, feed ingredients, or pet food. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.
Type:
Grant
Filed:
November 19, 2015
Date of Patent:
September 15, 2020
Assignee:
KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
Cassandra K. Jones, Roger A. Cochrane, Jason C. Woodworth, Steven S. Dritz
Abstract: The present invention discloses an improved process for the conversion of alkanes to alkenes in the presence of a recyclable mixed oxide and perovskite catalysts with high yield.
Type:
Grant
Filed:
November 8, 2017
Date of Patent:
September 15, 2020
Assignee:
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
Abstract: A distal radioulnar joint prosthesis for replacing the distal radioulnar joint and a method for its implantation is provided. Such a device includes an ulnar component, a radial component, and a motion liner. The ulnar component includes a stem, a collar, and a shell. The radial component includes a hemispherical ball and plate. The hemispherical ball of the radial component is secured with the radial plate and articulates with the ulnar shell via the motion liner. The prosthesis is designed to more accurately replicate the biomechanics of the distal wrist than currently used implants.
Type:
Grant
Filed:
April 29, 2016
Date of Patent:
September 15, 2020
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: An armor system for protecting vehicles and other equipment against projectiles and similar threats. A track is mounted on the equipment, and an upper sled and lower sled are moveably attached to the track. An armor panel is pivotally attached to one sled and is pivotally attached with arms to the other sled. The two sleds are independently actuated along the track, such that their relative positions determine both the translational and rotational position of the armor panel. The armor panel can be quickly rotated from an undeployed position against the vehicle through a desired arc outward from the vehicle, which increases the edge-on or nearly edge-on presentation of the armor panel to the projectile.
Type:
Grant
Filed:
April 26, 2018
Date of Patent:
September 15, 2020
Assignee:
Southwest Research Institute
Inventors:
James D. Walker, Daniel J. Pomerening, Kristopher C. Kozak, Nicholas J. Mueschke, Isaias S. Chocron, Gregory N. Wattis, Jesse A. Beavers, Oliver P. Harrison, Stephan J. Lemmer, Neal A. Seegmiller
Abstract: Methods for targeting apurinic/apyrimidinic endonuclease1/redox effector factor 1 (APE1/Ref-1) are disclosed. More particularly, methods for inhibiting APE1/Ref-1 and hypoxia-mediated signaling for decreasing survival and invasion of tumor cells exposed to hypoxic conditions are disclosed.
Type:
Grant
Filed:
May 5, 2016
Date of Patent:
September 15, 2020
Assignee:
Indiana University Research and Technology Corporation
Abstract: Polymers containing nitrogen-halogen covalent bonds, i.e., N-halamine polymers, are provided for use in water treatment by reducing or removing microbes and toxic chemicals. Polymers containing one or more amide groups, guanidino groups, or groups derived from urethane or urea, are directly halogenated. The hydrolysis of N-halamine bonds is closely monitored by the presence of different electron-donating or electron-withdrawing groups adjacent to the nitrogen(s) of the N-halamine groups, and the resultant polymer can be facilely reloaded with halogen. Released halogen is in the form of an oxidative halogen or a hypohalous acid, in an effective amount and in an extended period of time, to significantly reduce the amount of a wide range of microbes including Escherichia coli and bacteriophage MS2 in contaminated water. Sponges, beads, resins, gel, and membranes made from these polymers are used in water treatment.
Abstract: Provided is an apparatus that can check in real time a process of removing light induced degradation using precise carrier injection through an AC power supply device (power unit). An apparatus for reduction of light induced degradation with carrier injection includes: a housing in which high-temperature heat treatment is performed on a solar battery cell; a heating unit that is formed in the housing, on which the solar battery cell is seated, and that heats the solar battery cell; a jig unit that is formed in the housing and fixes the solar battery cell to the heating unit by pressing the solar battery cell seated on the heating unit; an LED array unit that has a plurality of LED light sources and radiates light to the solar battery cell; and a driving unit that is coupled to the jig unit and the LED array unit and rotates the jig unit or the LED array unit.
Type:
Grant
Filed:
September 27, 2019
Date of Patent:
September 15, 2020
Assignee:
GUMI ELECTRONICS & INFORMATION TECHNOLOGY RESEARCH INSTITUTE
Inventors:
Jun Hee Kim, Soo Min Kim, Sang Hoon Jung, Sam Soo Kim, Gyu Seok Choi
Abstract: An apparatus and method for collecting an audit trail in a virtual machine boot process, the audit-trail-collecting apparatus including an event detection unit for detecting a software interrupt event, a register state information extraction unit for extracting state information of a CPU register corresponding to a detection time of the software interrupt event, a monitoring unit for monitoring a change in a vector value corresponding to the software interrupt event in an interrupt vector table, a threat occurrence detection unit for detecting a threat occurrence in a virtual machine boot process based on at least one of the CPU register state information and a monitored result, and an audit trail collection unit for storing an audit trail corresponding to at least one of the CPU register state information and the monitored result when the threat occurrence is detected in the virtual machine boot process.
Type:
Grant
Filed:
March 28, 2018
Date of Patent:
September 15, 2020
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Sung-Jin Kim, Hyunyi Yi, Seong-Joong Kim, Woomin Hwang, Byung-Joon Kim, Chulwoo Lee, Hyoung-Chun Kim
Abstract: Provided is a service request method performed by an SMF device, including receiving, by an AMF device, an N2 message including a service request message from an access network, and receiving an Nsmf_PDUSession_UpdateSMContext request message including a PDU session ID and location information and an access type of a UE from the AMF device; verifying selection criteria of a UPF device based on the received location information of the UE and determining whether to use a new UPF device or an old UPF device; and sending an Nsmf_PDUSession_UpdateSMContext response message including information on a PDU session ID with the new UPF device or the old PUF device based on the determining. The access network is configured to receive, from the AMF device, an N2 request message including an MM NAS service accept and the access network is configured to perform a service through an RRC connection reconfiguration with the UE.
Type:
Grant
Filed:
August 16, 2018
Date of Patent:
September 15, 2020
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Soohwan Lee, Dongmyoung Kim, Myung Ki Shin
Abstract: The present disclosure relates to a novel method of laser-based fabrication of a carbon nanotube (CNT)-metal composite on a flexible substrate, and the fabricated CNT-metal composite that is bonded with the flexible substrate, and that has a high electrical conductivity, and that has a longer bending-fatigue life than the laser-sintered metal of the same type without CNTs onto the flexible substrate.
Abstract: The present invention discloses compounds of Formula I, wherein each of R1, R2, R3, R4, R5, R6, R7 and R8 are independently selected from H, OBn, OH, CH2OBn, CH2OH, CH3; R9 is selected from alkyl, substituted alkyl, hydroxyl alkyl, alkenyl, benzyl; process for preparation of N-alkylated glycolactam compounds of Formula I and their use for the synthesis of piperidine alkaloids and their analogues.
Type:
Grant
Filed:
May 5, 2017
Date of Patent:
September 15, 2020
Assignee:
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
Abstract: System and methods to provide ceiling-only suppression fire protection of up to fifty feet (50 ft.) of rack storage of cartoned unexpanded plastic commodities and less hazardous commodities, such as for example, Class 1, Class 2, Class 3, Class 4 and/or combinations thereof beneath a ceiling having a maximum ceiling height up to fifty-five feet (55 ft.). The systems and methods provide for hydraulic and system parameters that include a hydraulic design area based upon five to no more than twelve hydraulically most remote sprinklers spaced at a preferred sprinkler-to-sprinkler spacing of eight to ten feet (8-10 ft.) coupled to two to four branch lines tied to a common cross main supply pipe of firefighting fluid.
Type:
Grant
Filed:
April 7, 2020
Date of Patent:
September 15, 2020
Assignees:
Viking Group, Inc., Minimax Viking Research & Development GmbH
Inventors:
Martin H. Workman, Scott T. Franson, James E. Golinveaux, Jason Thomas Watson