Abstract: The present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy, particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B, for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compounds of the invention include compounds having the formula IA or a pharmaceutically acceptable salt thereof, wherein R1a, R3a, R5a, Xa and Ya are as defined herein.

Abstract: A bone implant includes at least one spiral and at least one pillar. The spiral surrounds an accommodating space. The pillar is disposed in the accommodating space and connected to the spiral. The pillar has at least one notch.

Abstract: A system and method to determine an angular movement of an arbor integral with a crown of a watch, the arbor being rotatable in a longitudinal direction. Included is a rotating reflector mounted on the arbor, and two emitter/detector pairs disposed on either side of the reflector. Each emitter/detector pair includes a light source for illuminating the reflector, and a light detector for receiving the light reflected on the reflector and for generating an electrical signal representative of the reflected light. A processor processes the electrical signals and determine a parameter relating to the angular movement of the arbor. The rotating reflector's visible outer surface changes when the reflector rotates on itself in a regular manner, such that the representative electrical signal generated by said detector of the pair has a substantially sinusoidal shape when the reflector rotates on itself in a regular manner in a same direction of rotation.

Abstract: The present disclosure relates to novel ?-opioid receptor agonists, and the method of making and using the novel ?-opioid receptor agonists. The novel ?-opioid receptor agonists are selective ?-opioid receptor agonists that have substantially no beta-arrestin 2 recruitment or low beta-arrestin 2 recruitment. The novel ?-opioid receptor agonists may be used for the treatment for alcohol use disorders and other co-occurring psychiatric disorders.

Abstract: An image encoding/decoding method and apparatus for performing intra prediction using a plurality of reference sample lines are provided. An image decoding method may comprise configuring a plurality of reference sample lines, reconstructing an intra prediction mode of a current block, and performing intra prediction for the current block based on the intra prediction mode and the plurality of reference sample lines.

Abstract: The present invention relates to a three-dimensional (3D) tissue-like implant for transplanting to a subject in need comprising a cell cluster comprising mesenchymal stem cells (MSCs) and specific cells differentiated therefrom. The present invention also relate to a method of preparing a 3D-tissue-like implant from MSCs, particularly by seeding MSCs in alginate scaffolds and culturing the alginate scaffolds with MSCs in a 3-D perfusion condition. Further, the present invention provides a method for treating a defect in a recipient patient in need by administering a 3D tissue-like implant as described herein to the patient at a defective site e.g. a bone defective site.

Abstract: An oil pump includes a pump housing, a pump shaft, and a pump rotor assembly. The pump housing is capable of forming a pump cavity. The pump cavity includes a first cavity and a second cavity. The pump rotor assembly is provided in the first cavity. At least part of the pump shaft is provided in the second cavity. The pump rotor assembly includes a first rotor and a second rotor. The first rotor is capable of rotating the second rotor, and is fixedly connected to the pump shaft. The pump shaft is capable of rotating the first rotor. The first rotor includes a connecting portion. A connecting hole is provided in the connecting portion. At least part of the pump shaft is provided in the connecting hole. At least part of the connecting portion engages with at least part of the pump shaft.

Abstract: The invention discloses an indel molecular marker closely linked with pumpkin photoperiod insensitivity and application of the indel molecular marker, and belongs to the technical field of molecule detection. The indel molecular marker SEQ7593 is located on a tenth chromosome of a Cucurbita moschata, and is 280 bp in size. The nucleotide sequence of the indel molecular marker is shown as SEQ ID NO.1. The indel molecular marker SEQ7593 can be directly used for creating an assistant breeding system of photoperiod insensitivity character molecular markers. Primer amplification designed according to the Indel molecular marker can be applied to assistant breeding of pumpkin breed improvement molecules in a simple, rapid and high-throughput manner, technical support is provided for pumpkin photoperiod insensitivity molecular breeding, and time for conventional gene positioning is shortened greatly.

Abstract: Embodiments of the disclosure provide a system for analyzing noise data for light detection and ranging (LiDAR). The system includes a communication interface configured to sequentially receive noise data of the LiDAR in time windows, at least one storage device configured to store instructions, and at least one processor configured to execute the instructions to perform operations. Exemplary operations include determining an estimated noise value of a first time window using the noise data received in the first time window and determining an instant noise value of a second time window using the noise data received in the second time window. The second time window is immediately subsequent to the first time window. The operations also include determining an estimated noise value of the second time window by aggregating the estimated noise value of the first time window and the instant noise value of the second time window.

Abstract: An apparatus for dynamically adjusting depth resolution is provided. The apparatus includes a depth capture module, an image capture module and a computing unit. The depth capture module obtains a set of images for disparity computation. The image capture module obtains a high-resolution image. The computing unit computes a disparity map and a corresponding depth map using the set of images obtained by the depth capture module, and sets a 3D region of interest according to a pre-defined object feature, the high-resolution image and the depth map. The 3D region of interest can be dynamically adjusted by tracking the movement of the object. In the 3D region of interest, the computing unit re-computes the depth map in higher resolution along Z axis by re-computing the disparity map in appropriate sub-pixels and allocating the required number of bits to store the sub-pixel disparity values.

Abstract: Technologies for executing a virtual character development application using machine learning are described herein. In typical simulation applications, a user may be enabled to create a virtual character and navigate a virtual world. A typical simulation application may accept inputs from the user, determine actions initiated by the user based on the inputs, determine subsequent outcomes of the user-initiated actions, and mold the simulation according to the outcomes. However, most outcomes may be predetermined and predictable by design. In contrast, some embodiments may include a server configured to execute a virtual character development application in conjunction with one or more client devices. A user may utilize a client device to create and develop a virtual character within the application. The user may be enabled to provide inputs to the virtual character development application, and the artificial component may process the input and extract information associated with the virtual character.

Abstract: Devices, system and methods a circuit, including a resistor, a normal capacitor and a ferroelectric capacitor connected in series. An input terminal to provide an input voltage across the circuit. An output terminal to deliver an output voltage taken across the normal capacitor. The circuit comprises a ferroelectric layer sandwiched between a first buffer layer and a second buffer layer. The first buffer layer contacts a portion of a first metal layer and first metal layer extends beyond the first buffer layer. A dielectric layer sandwiched between a second metal layer and a third metal layer. Such that the second metal layer extends beyond the dielectric layer and in contact with the second buffer layer. Wherein the ferroelectric capacitor is formed by the first metal layer. The ferroelectric layer sandwiched between the first buffer layer and the second buffer layer, and the second metal layer.

Abstract: An osteo-implant including two end portions, at least one middle structure, and a plurality of connection portions is provided. The middle structure is disposed between the two end portions and includes a plurality of middle portions. The middle portions are connected to the two end portions through the connection portions. When the two end portions are moved relatively along an axial direction of the osteo-implant, the two end portions drive the middle portions to push with each other and have displacements along a radial direction of the osteo-implant through the connection portions, such that an outer diameter of the osteo-implant is increased by the middle portions.

Abstract: Methods of purifying mucin, purified mucin, and products comprising the purified mucin. The methods include combining a mucin-containing substance with water and one or more purification agents to form a purification mixture, incubating the purification mixture for a time sufficient to form a mucin precipitate in a liquid phase, and separating the mucin precipitate from the liquid phase. The purification agents include one or more of a surfactant, a chelating agent, and a protic solvent. The mucin purified from the methods can be used alone or in combination with a biopolymer such as a tannin and chitosan and can be used to generate materials in the form of a gel, a foam, a film, or a powder.

Abstract: A decorative item made from a moulded material having a density of between 2 and 7 g/cm3, wherein the moulded material includes by weight: 60 to 90% of a metallic or ceramic material having a density higher than or equal to 5 g/cm3, 10 to 32% of a plastic material including a thermoplastic resin and a coupling agent, 0 to 8% of a reinforcement, 0 to 3% of a pigment. Also, a method of manufacturing this decorative item by injection moulding.

Abstract: This document describes methods and materials for improving treatment of hypertension. For example, this document describes methods and devices for electroporation of nerves in the renal area to treat hypertension.

Abstract: The invention relates to a composition for treatment and management of Dementia. The composition is a combination of herbs and bhasmas. It includes herbs such as Bacopa monnieri, Convolvulus pluricaulis, Mucuna pruriens, Nardostachys jatamansi, Rauwolfia serpentina, Withania somnifera, Acorus calamus, Sida cordifolia and Emblica officinalis. It further includes Shilajit, Rasa sindura and bhasmas. The composition is useful in treating Cognitive dysfunction, Dementia and other cognitive impairments associated with neuro-degenerative disorders. Further, the composition is also useful in restoring and improving cognitive function.

Abstract: An indicator device is suitable for a mixed reality device. The indicator device includes a body, a light source unit, at least two positioning elements, a triggering unit and a control unit. The light source unit is disposed on the body and generates a light source. The two elements are disposed separately on the body, wherein the light source unit and the positioning elements are disposed on different axes. The triggering unit is disposed on the body and generates a trigger signal. The control unit is disposed inside the body and is connected to the light source unit and the triggering unit. The control unit receives the trigger signal to generate a first control signal, thereby controlling the light-emitting state of the light source.

Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

Abstract: A multi-axis force sensor including a central portion, an outer ring portion, and at least one sensing portion disposed along an axial direction of an axis is provided. The sensing portion includes a first and a second elements connected with each other, and at least one first and at least one second strain gauges. A first end surface of the first element is connected to the central portion, and a second end surface of the second element is connected to the outer ring portion. A normal vector of the first end surface is parallel to the axis and the axis passes through a centroid of the first end surface. When the first end surface is subjected to an axial force, a first strain of a first sensing region of the first element in the axial direction is smaller than a second strain of a second sensing region of the second element in the axial direction.